INT48313

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Context Info
Confidence 0.47
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 19
Total Number 19
Disease Relevance 14.44
Pain Relevance 6.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NTRK1) endosome (NTRK1) plasma membrane (NTRK1)
Anatomy Link Frequency
nerve 3
autonomic 2
ventral roots 1
peripheral nerve 1
thyroid gland 1
NTRK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 73 100.00 Very High Very High Very High
Trk A 5 100.00 Very High Very High Very High
Hsan 15 99.76 Very High Very High Very High
backache 1 99.24 Very High Very High Very High
Pain 195 96.44 Very High Very High Very High
Calcitonin gene-related peptide 15 88.64 High High
substance P 11 88.36 High High
Inflammation 70 87.36 High High
metalloproteinase 6 83.36 Quite High
Osteoarthritis 90 82.40 Quite High
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 330 100.00 Very High Very High Very High
Carcinoma 50 99.92 Very High Very High Very High
Hereditary Sensory And Autonomic Neuropathies 27 99.76 Very High Very High Very High
Low Back Pain 1 99.24 Very High Very High Very High
Metastasis 52 99.20 Very High Very High Very High
Neuroma 6 99.10 Very High Very High Very High
Diabetic Nephropathy 6 98.84 Very High Very High Very High
Cancer 127 98.76 Very High Very High Very High
Cold Sores 4 98.40 Very High Very High Very High
Wound Healing 13 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A novel TRK A (NTRK1) mutation associated with hereditary sensory and autonomic neuropathy type V.
NTRK1 Binding (associated) of in autonomic associated with diabetic nephropathy
1) Confidence 0.47 Published 2001 Journal Ann. Neurol. Section Title Doc Link 11310631 Disease Relevance 0.88 Pain Relevance 0.24
A novel TRK A (NTRK1) mutation associated with hereditary sensory and autonomic neuropathy type V.
TRK A Binding (associated) of in autonomic associated with diabetic nephropathy
2) Confidence 0.47 Published 2001 Journal Ann. Neurol. Section Title Doc Link 11310631 Disease Relevance 0.88 Pain Relevance 0.24
TrkA and p75NGFR negatively correlated and were both associated with abdominal or back pain and perineural invasion.
TrkA Binding (associated) of associated with backache
3) Confidence 0.47 Published 2005 Journal Oncol. Rep. Section Abstract Doc Link 15944784 Disease Relevance 1.11 Pain Relevance 0.51
Novel frameshift and splice site mutations in the neurotrophic tyrosine kinase receptor type 1 gene (NTRK1) associated with hereditary sensory neuropathy type IV.
NTRK1 Binding (associated) of associated with hsan
4) Confidence 0.37 Published 2006 Journal Neuromuscul. Disord. Section Title Doc Link 16373086 Disease Relevance 0.81 Pain Relevance 0.20
Moreover, leptomeningeal cells and nonneuronal cells of the ventral roots were shown to bind antibodies to both the trk and trkB gene products.
trk Binding (bind) of in ventral roots
5) Confidence 0.36 Published 1994 Journal J. Comp. Neurol. Section Abstract Doc Link 7510731 Disease Relevance 0.16 Pain Relevance 0.67
Recent investigations point to Trk A, the high affinity receptor for nerve growth factor (NGF), as a candidate for the site of the mutation that causes the disorder.
Trk Binding (point) of in nerve associated with nerve growth factor and trk a
6) Confidence 0.36 Published 2004 Journal J. Clin. Immunol. Section Abstract Doc Link 15163901 Disease Relevance 0.77 Pain Relevance 0.67
NTs interact with classes of receptors on responsive cells: protein-tyrosine kinase-type receptors (Trk family).
Trk Binding (interact) of
7) Confidence 0.35 Published 2009 Journal Ann Cardiol Angeiol (Paris) Section Abstract Doc Link 19281964 Disease Relevance 0.36 Pain Relevance 0.07
Novel frameshift and splice site mutations in the neurotrophic tyrosine kinase receptor type 1 gene (NTRK1) associated with hereditary sensory neuropathy type IV.
tyrosine kinase receptor type 1 gene Binding (associated) of associated with hsan
8) Confidence 0.33 Published 2006 Journal Neuromuscul. Disord. Section Title Doc Link 16373086 Disease Relevance 0.81 Pain Relevance 0.20
We reported that TRKA is the gene responsible for CIPA and we developed a comprehensive strategy to screen for TRKA mutations and polymorphisms, as based on the gene's structure and organization.
TRKA Binding (screen) of associated with hsan
9) Confidence 0.32 Published 2001 Journal Hum. Mutat. Section Abstract Doc Link 11668614 Disease Relevance 0.89 Pain Relevance 0.54
Immunhistochemistry of 10 traumatic human peripheral nerve neuromas and 5 normal digital nerves revealed a high immunoreactivity for the nerve growth factor (NGF) receptors p75 and trkA and the glial cell line-derived neurotrophic factor (GDNF) receptor GFRalpha-1.
trkA Binding (immunoreactivity) of in peripheral nerve associated with nerve growth factor and neuroma
10) Confidence 0.32 Published 2002 Journal Muscle Nerve Section Abstract Doc Link 11932982 Disease Relevance 0.34 Pain Relevance 0.05
Nerve growth factor (NGF) and its high-affinity receptor TrkA are involved in stimulating epithelial cancer cell growth and perineural invasion, as well as in pain generation in chronic benign disorders.
TrkA Binding (affinity) of in Nerve associated with pain and cancer
11) Confidence 0.31 Published 1999 Journal J. Clin. Oncol. Section Abstract Doc Link 10561305 Disease Relevance 0.54 Pain Relevance 0.35
Interactions of nerve growth factor (NGF) and its receptor tropomyosin-related kinase (trkA) appear to be critical for maintaining HSV latency.
trkA Binding (Interactions) of in nerve associated with cold sores and nerve growth factor
12) Confidence 0.30 Published 2008 Journal J. Neurovirol. Section Abstract Doc Link 19016376 Disease Relevance 0.40 Pain Relevance 0.23
Management of MTC
MTC Binding (Management) of associated with thyroid neoplasm
13) Confidence 0.25 Published 2010 Journal Journal of Thyroid Research Section Body Doc Link PMC2956973 Disease Relevance 1.19 Pain Relevance 0
There is considerable evidence showing that the system constituted by the NGF and its high-affinity receptor TrkA plays a fundamental role in the molecular processes underlying the main forms of "persistent" pain.
TrkA Binding (affinity) of associated with pain
14) Confidence 0.24 Published 2009 Journal Eur Spine J Section Abstract Doc Link 19399531 Disease Relevance 0.60 Pain Relevance 0.48
In the present study, the animals that received IP MTC perioperatively and on the 3rd potoperative day had significantly lower mean tissue hydroxyproline contents and anastomotic bursting pressures than the controls.
MTC Binding (received) of
15) Confidence 0.14 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1079801 Disease Relevance 0.78 Pain Relevance 0
Each NT binds with high affinity to a receptor tyrosine kinase (Trk): NGF to TrkA, BDNF and NT4/5 to TrkB and NT3 to TrkC.
Trk Binding (binds) of associated with nerve growth factor
16) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.16 Pain Relevance 0.87
NT3 also binds with TrkA and TrkB.
TrkA Binding (binds) of
17) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.12 Pain Relevance 0.78
As such, Rab7 activity regulates the lysosome-mediated degradation of endocytic cargos such as activated EGF receptors, internalized cholesterol and neurotrophic factor receptors such as TrkA (6,9,10).
TrkA Binding (internalized) of
18) Confidence 0.09 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.25 Pain Relevance 0.03
Thyroidectomy is the preferred initial management of PTC, FC, MTC, HCC, and isolated metastases to the thyroid gland (Udelsman and Chen 1999; Chen et al 1999; Cheema et al 2006; Greenblatt et al 2007).
MTC Binding (management) of in thyroid gland associated with thyroid neoplasm, carcinoma and metastasis
19) Confidence 0.07 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 1.42 Pain Relevance 0

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