INT48314

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Context Info
Confidence 0.75
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 7.84
Pain Relevance 7.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (NTRK2) plasma membrane (NTRK2)
Anatomy Link Frequency
dorsal horn 2
neuronal 1
chondrocyte 1
Brain 1
musculoskeletal system 1
NTRK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 435 100.00 Very High Very High Very High
Hippocampus 7 99.68 Very High Very High Very High
sodium channel 4 99.48 Very High Very High Very High
bDMF 84 99.16 Very High Very High Very High
Pain 119 99.04 Very High Very High Very High
Dorsal horn 19 98.68 Very High Very High Very High
Neuropathic pain 2 98.44 Very High Very High Very High
tetrodotoxin 1 97.84 Very High Very High Very High
Inflammation 14 97.60 Very High Very High Very High
antidepressant 58 97.54 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 95 99.04 Very High Very High Very High
Depression 89 98.94 Very High Very High Very High
Disease 590 98.72 Very High Very High Very High
Osteoarthritis 24 98.64 Very High Very High Very High
Neuropathic Pain 2 98.44 Very High Very High Very High
Nociception 59 98.28 Very High Very High Very High
INFLAMMATION 18 97.60 Very High Very High Very High
Neurodegenerative Disease 32 95.04 Very High Very High Very High
Intervertebral Disk Degeneration 32 92.48 High High
Death 8 91.62 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, by screening candidate genes with an antisense messenger RNA expression approach and by co-expressing the receptor tyrosine kinase TrkB and various sodium channels, we demonstrate that the tetrodotoxin-insensitive sodium channel Na(V)1.9 underlies the neurotrophin-evoked excitation.
Gene_expression (expressing) of TrkB associated with tetrodotoxin and sodium channel
1) Confidence 0.75 Published 2002 Journal Nature Section Abstract Doc Link 12384689 Disease Relevance 0 Pain Relevance 0.32
However, TrkB and serpin peptidase inhibitor, clade e (nexin, plasminogen activator inhibitor type 1), member 2 (SERPINE2) were present in the set of 1,663 genes and located in module 1.
Gene_expression (present) of TrkB
2) Confidence 0.67 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.62 Pain Relevance 0.60
By this reasoning, it can be concluded that high levels of TrkB and PAI-1 imply decreased levels of BDNF, which is detrimental for the survival of neuronal populations.
Gene_expression (levels) of TrkB in neuronal associated with bdmf
3) Confidence 0.67 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.73 Pain Relevance 0.57
Interestingly, the expression levels of TrkB and PAI-1 were elevated in the AD samples.
Gene_expression (expression) of TrkB associated with disease
4) Confidence 0.67 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.69 Pain Relevance 0.57
In addition, the binding of antibodies against synthetic peptides representing unique sequences of residues in the products of the trk and trkB protooncogenes was analyzed.
Gene_expression (products) of trkB
5) Confidence 0.65 Published 1994 Journal J. Comp. Neurol. Section Abstract Doc Link 7510731 Disease Relevance 0 Pain Relevance 0.39
Interestingly, the expression levels of TrkB and PAI-1 were elevated in the AD samples.
Gene_expression (levels) of TrkB associated with disease
6) Confidence 0.52 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.69 Pain Relevance 0.57
Nevertheless, expression of Trk-A and Trk-B by human disc cells in terms of disease pathology has yet to be fully examined.
Gene_expression (expression) of Trk-B associated with disease
7) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.43 Pain Relevance 0.48
In non-degenerate, moderate and severely degenerate IVD tissue, the receptors Trk-A and Trk-B were expressed by the chondrocyte-like cells of the IVD, suggesting that neurotrophins in the IVD may exert autocrine effects on the disc cells themselves.
Gene_expression (expressed) of Trk-B in chondrocyte
8) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.55 Pain Relevance 0.65
NGF, BDNF, Trk-A and Trk-B protein expression in the nondegenerate and degenerate human IVD
Gene_expression (expression) of Trk-B protein associated with nerve growth factor
9) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.13 Pain Relevance 0.25
Indeed, both receptors have been identified in cells of the musculoskeletal system, and more recent studies have demonstrated Trk-A and Trk-B expression in human disc cells [14-17,19,21].
Gene_expression (expression) of Trk-B in musculoskeletal system
10) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.34 Pain Relevance 0.43
Trk-A and Trk-B protein expression in the non-degenerate and degenerate human IVD
Gene_expression (expression) of Trk-B protein
11) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.22 Pain Relevance 0.04
Using immunohistochemistry we have therefore investigated NGF and BDNF expression, including expression of the receptors Trk-A and Trk-B, in non-degenerate, moderately degenerate and severely degenerate human IVD tissue, and we have examined the effects of IL-1?
Gene_expression (expression) of Trk-B associated with nerve growth factor
12) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.16 Pain Relevance 0.33
Key observations leading to and strengthening this theory are: (1) neurotrophic factors, especially BDNF and VEGF, are under-expressed in limbic structures implicated in depression (especially the hippocampus) and may contribute to their observed atrophy and increased sensitivity to death (Sapolsky, 2000; Duman and Monteggia, 2006); (2) HPA-axis dysfunction exacerbates this phenomenon, while effective antidepressant treatments counteract it by enhancing hippocampal BDNF mRNA expression through the cAMP-CREB cascade (Duman et al., 1997, 2000); and (3) ECT and MAOI antidepressants, considered to be the most effective at relieving depressive symptoms, were shown to most significantly increase BDNF and trkB (the BDNF receptor) mRNA expression in the hippocampus (Nibuya et al., 1995).


Gene_expression (expression) of trkB in hippocampus associated with antidepressant, depression, frailty, hippocampus and death
13) Confidence 0.25 Published 2010 Journal Frontiers in Neuroengineering Section Body Doc Link PMC2901135 Disease Relevance 1.18 Pain Relevance 0.45
The high affinity receptor for BDNF, tropomyosine receptor kinase B (TrkB), is expressed by post-synaptic neurons of the dorsal horn.
Gene_expression (expressed) of tropomyosine receptor kinase B in dorsal horn associated with dorsal horn
14) Confidence 0.24 Published 2002 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 12589922 Disease Relevance 0.49 Pain Relevance 0.51
The high affinity receptor for BDNF, tropomyosine receptor kinase B (TrkB), is expressed by post-synaptic neurons of the dorsal horn.
Gene_expression (expressed) of TrkB in dorsal horn associated with dorsal horn
15) Confidence 0.24 Published 2002 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 12589922 Disease Relevance 0.48 Pain Relevance 0.51
Immunohistochemical analysis was performed to examine the expression of NGF, BDNF and their high-affinity receptors Trk-A and Trk-B in human IVD samples, divided into three categories: non-degenerate, moderate degeneration and severe degeneration.
Spec (examine) Gene_expression (expression) of Trk-B in IVD associated with nerve growth factor
16) Confidence 0.22 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2575613 Disease Relevance 0.18 Pain Relevance 0.39
Expression of Trk-A and Trk-B by cells of the nondegenerate and degenerate IVD suggests an autocrine role for neurotrophins in regulation of disc cell biology.
Gene_expression (Expression) of Trk-B
17) Confidence 0.22 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2575613 Disease Relevance 0.18 Pain Relevance 0.43
Brain-derived neurotrophic factor (BDNF) has multiple effects on tropomyosin-related receptor kinase B--(TrkB) expressing neurons, including potentiation of spinal nociceptive transmission and stimulation of axon outgrowth.
Gene_expression (expressing) of tropomyosin-related receptor kinase B in Brain associated with nociception
18) Confidence 0.05 Published 2008 Journal Pain Section Abstract Doc Link 18158214 Disease Relevance 0.76 Pain Relevance 0.32

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