INT48335

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Context Info
Confidence 0.56
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 38
Total Number 38
Disease Relevance 16.22
Pain Relevance 12.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (NOSTRIN) cytoplasmic membrane-bounded vesicle (NOSTRIN) plasma membrane (NOSTRIN)
cytoskeleton (NOSTRIN) cytoplasm (NOSTRIN)
Anatomy Link Frequency
endothelium 3
smooth muscle 2
diaphragm 1
annulus 1
trachea 1
NOSTRIN (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 23 99.96 Very High Very High Very High
corticosteroid 4 99.92 Very High Very High Very High
Calcitonin gene-related peptide 8 99.80 Very High Very High Very High
opioid receptor 5 99.80 Very High Very High Very High
cytokine 65 99.78 Very High Very High Very High
Opioid 24 99.76 Very High Very High Very High
fibrosis 4 99.74 Very High Very High Very High
narcan 3 99.72 Very High Very High Very High
Cholecystokinin 1 99.72 Very High Very High Very High
cINOD 35 99.54 Very High Very High Very High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 56 99.96 Very High Very High Very High
Fibrosis 2 99.74 Very High Very High Very High
Ulcers 36 99.60 Very High Very High Very High
Thrombosis 11 99.46 Very High Very High Very High
INFLAMMATION 257 99.42 Very High Very High Very High
Breast Cancer 21 99.40 Very High Very High Very High
Apoptosis 57 99.30 Very High Very High Very High
Injury 34 99.12 Very High Very High Very High
Stress 176 99.06 Very High Very High Very High
Migraine Disorders 6 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of inhibition of nitric oxide synthase on nonadrenergic, noncholinergic nerve-mediated responses in circular smooth muscle of the human esophageal body and lower esophageal sphincter (LES) was examined in vitro.
Negative_regulation (inhibition) of nitric oxide synthase in smooth muscle
1) Confidence 0.56 Published 1994 Journal Dig. Dis. Sci. Section Abstract Doc Link 7512016 Disease Relevance 0.08 Pain Relevance 0
A dose-response study of nitric oxide synthase inhibition in different vascular beds in man.
Negative_regulation (inhibition) of nitric oxide synthase
2) Confidence 0.52 Published 2003 Journal Eur. J. Clin. Pharmacol. Section Title Doc Link 13680036 Disease Relevance 0 Pain Relevance 0.08
The suspected mechanism of action of methylene blue is inhibition of the enzyme nitric oxide synthase, which ultimately prevents the smooth muscle dilation that accompanies anaphylaxis.
Negative_regulation (inhibition) of nitric oxide synthase in smooth muscle associated with anaphylaxis
3) Confidence 0.51 Published 2008 Journal AANA J Section Abstract Doc Link 18777811 Disease Relevance 0.99 Pain Relevance 0.08
This effect was completely blocked by 30 microm of N(omega)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthase.
Negative_regulation (inhibitor) of nitric oxide synthase
4) Confidence 0.49 Published 1999 Journal Pharmacol. Res. Section Abstract Doc Link 10433870 Disease Relevance 0.09 Pain Relevance 0.33
Opioids are non-competitive inhibitors of nitric oxide synthase in T47D human breast cancer cells.
Negative_regulation (inhibitors) of nitric oxide synthase associated with breast cancer and opioid
5) Confidence 0.46 Published 2001 Journal Cell Death Differ. Section Title Doc Link 11526449 Disease Relevance 0.37 Pain Relevance 1.02
The responses were also examined in the presence of opioid receptor blocker, nitric oxide synthase inhibitor, beta-adrenoceptor blocker, or cyclooxygenase inhibitor.
Negative_regulation (inhibitor) of nitric oxide synthase associated with opioid receptor
6) Confidence 0.45 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11273940 Disease Relevance 0 Pain Relevance 0.48
The inhibitor of nitric oxide synthase, NG-nitro-L-arginine (3 x 10(-5) mol/l), abolished the relaxations at the lowest frequencies, while slow-developing relaxations were still observed at high frequencies (16 and 32 Hz).
Negative_regulation (inhibitor) of nitric oxide synthase
7) Confidence 0.43 Published 1997 Journal Clin. Sci. Section Abstract Doc Link 9093007 Disease Relevance 0.11 Pain Relevance 0.15
The present study suggests that relaxations of human intracavernosal small penile arteries induced by non-adrenergic non-cholinergic nerve stimulation partially involve nitric oxide and also another inhibitory transmitter causing relaxations resistant to nitric oxide synthase blockade.
Negative_regulation (blockade) of nitric oxide synthase in nerve
8) Confidence 0.43 Published 1997 Journal Clin. Sci. Section Abstract Doc Link 9093007 Disease Relevance 0 Pain Relevance 0.07
In the presence of L-N(G)-nitroarginine methyl ester (nitric oxide synthase inhibitor), KCl (prevention of hyperpolarization), or both, sevoflurane at 4% enhanced the relaxation in the arteries (P < 0.05).
Negative_regulation (inhibitor) of nitric oxide synthase
9) Confidence 0.43 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15271717 Disease Relevance 0.08 Pain Relevance 0.20
The nitric oxide synthase inhibitor, N omega-nitro-L-arginine (NNA), at 10(-5) M, inhibited the relaxation, but had no significant effect on the spontaneous tension (13.0 +/- 2.6 mN/mm2, P = 0.07).
Negative_regulation (inhibitor) of nitric oxide synthase
10) Confidence 0.41 Published 1994 Journal Dig. Dis. Sci. Section Abstract Doc Link 7512016 Disease Relevance 0.09 Pain Relevance 0.05
This model has predicted efficacy of nitric oxide synthase inhibition and calcitonin gene-related peptide receptor blockade.
Negative_regulation (inhibition) of nitric oxide synthase associated with calcitonin gene-related peptide
11) Confidence 0.41 Published 2009 Journal Cephalalgia Section Abstract Doc Link 19250288 Disease Relevance 0.53 Pain Relevance 0.58
The relaxation was enhanced by guanethidine and superoxide dismutase, inhibited by nitric oxide synthase inhibitors, blocked by tetrodotoxin, and unaffected by atropine, propranolol, or indomethacin.
Negative_regulation (inhibitors) of nitric oxide synthase associated with tetrodotoxin and guanethidine
12) Confidence 0.38 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7733373 Disease Relevance 0 Pain Relevance 0.26
The inhibitor L-NAME, which blocks nitric oxide synthase, prevented the PEF-stimulated increase in nitric oxide, cGMP, and DNA content.
Negative_regulation (blocks) of nitric oxide synthase
13) Confidence 0.28 Published 2008 Journal J. Orthop. Res. Section Abstract Doc Link 18240331 Disease Relevance 0.12 Pain Relevance 0.06
In addition to spinal opioids other drugs may produce an antinociceptive effect when administered by the spinal route, such as local anesthetics, NSAID, alpha 2-agonists, calcium-channel blockers, NMDA antagonists, cholinergic drugs, peptides such as somatostatin, octreotide or calcitonin, adenosine agonists, benzodiazepines, neurokinin and cholecystokinin antagonists, nitric oxide synthase inhibitors, corticosteroids, and enkephalinase inhibitors.
Negative_regulation (inhibitors) of nitric oxide synthase in spinal associated with corticosteroid, somatostatin, antinociceptive, local anesthetic, adenocard, antagonist, cinod, agonist, opioid and cholecystokinin
14) Confidence 0.28 Published 1996 Journal Minerva Anestesiol Section Abstract Doc Link 9102586 Disease Relevance 0.27 Pain Relevance 1.61
We demonstrate that in brachial arteries of steroid exposed offspring: KCl induced contraction is increased after endothelium removal or incubation with inhibitors of nitric oxide synthase or cyclooxygenase; acetylcholine-induced relaxation is increased; sensitivity to endothelin-1 (ET-1) is increased and this effect is decreased by the ETB antagonist BQ-788.
Negative_regulation (inhibitors) of nitric oxide synthase in endothelium associated with antagonist
15) Confidence 0.25 Published 2006 Journal Pediatr. Res. Section Abstract Doc Link 17065564 Disease Relevance 0 Pain Relevance 0.14
Interleukin 25 and nitric oxide synthase 1 were downregulated.
Negative_regulation (downregulated) of nitric oxide synthase
16) Confidence 0.23 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.27 Pain Relevance 0.08
In our studies, we also identified a significant decrease in nitric oxide synthase in our senescent annulus cells compared to the non-senescent cells.
Negative_regulation (decrease) of nitric oxide synthase in annulus
17) Confidence 0.23 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.34 Pain Relevance 0
These effects were antagonized by nitric oxide synthase inhibitors and naloxone.
Negative_regulation (inhibitors) of nitric oxide synthase
18) Confidence 0.23 Published 2007 Journal Eur J Anaesthesiol Section Body Doc Link 17583593 Disease Relevance 0 Pain Relevance 0
Segments of human temporal artery were incubated in organ culture for 2 days in the absence or presence of interleukin-1 beta (IL-1 beta), with or without nonsteroidal anti-inflammatory drugs, glucocorticoids or a nitric oxide synthase inhibitor.
Negative_regulation (inhibitor) of nitric oxide synthase in temporal artery associated with inflammation and cinod
19) Confidence 0.22 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12126971 Disease Relevance 0.10 Pain Relevance 0.27
It may be through activation of the cytokines selective inhibition of inducible nitric oxide synthase which has been shown to reduce the progression of experimental osteoarthritis in vivo [37].
Negative_regulation (inhibition) of nitric oxide synthase associated with osteoarthritis and cytokine
20) Confidence 0.19 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2526991 Disease Relevance 0.94 Pain Relevance 0.40

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