INT48338

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Context Info
Confidence 0.52
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.25
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ahsg) extracellular region (Ahsg) protein complex assembly (Ahsg)
protein complex (Ahsg)
Anatomy Link Frequency
bile duct 1
dorsal horn 1
Ahsg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 3 99.52 Very High Very High Very High
Clonidine 8 99.00 Very High Very High Very High
nMDA receptor 1 98.92 Very High Very High Very High
Bile 3 97.92 Very High Very High Very High
spinal dorsal horn 1 90.32 High High
antagonist 1 85.44 High High
agonist 1 77.76 Quite High
intrathecal 1 74.16 Quite High
referred pain 1 26.80 Quite Low
Disease Link Frequency Relevance Heat
Stress Incontinence 3 87.04 High High
Referred Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Isobutylmethylxanthine (IBMX) affected BSP disposition in a similar fashion as clonidine, in rats without bile duct cannulation only; no effect of IBMX could be observed in bile duct cannulation rats.
Gene_expression (disposition) of BSP in bile duct associated with bile and clonidine
1) Confidence 0.52 Published 1993 Journal Eur J Drug Metab Pharmacokinet Section Abstract Doc Link 7512026 Disease Relevance 0 Pain Relevance 0.90
When compared with vehicle solution, intracolonic mustard oil sensitized the NMDA receptor NR2B subunit-dependent reflex activity and increased expression levels of phosphorylated Akt (pAkt) and phosphorylated NR2B (pNR2B) in dorsal horn.
Gene_expression (expression) of phosphorylated NR2B in dorsal horn associated with nmda receptor and dorsal horn
2) Confidence 0.04 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20067569 Disease Relevance 0.25 Pain Relevance 0.26

General Comments

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