INT48357

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Context Info
Confidence 0.39
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.04
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Anpep) peptidase activity (Anpep)
Anatomy Link Frequency
T-cell 2
B-cell 1
peritoneal macrophages 1
Anpep (Mus musculus)
Pain Link Frequency Relevance Heat
orphanin 14 98.64 Very High Very High Very High
Enkephalin 6 95.36 Very High Very High Very High
cytokine 8 90.12 High High
Inflammation 25 89.76 High High
rheumatoid arthritis 102 81.28 Quite High
Arthritis 7 77.84 Quite High
metalloproteinase 1 75.76 Quite High
Pain 4 70.40 Quite High
Opioid 2 65.52 Quite High
Neuropeptide 1 60.64 Quite High
Disease Link Frequency Relevance Heat
Necrosis 3 94.04 High High
Cancer 3 93.68 High High
INFLAMMATION 25 89.76 High High
Chromosome Aberrations 2 88.24 High High
Leukemia 6 86.48 High High
Rheumatoid Arthritis 102 81.28 Quite High
Arthritis 8 77.84 Quite High
Residual Neoplasm 4 75.00 Quite High
Acute Myeloid Leukemia 2 75.00 Quite High
Sprains And Strains 1 67.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of CD4+ T cells results in a small increase per cell in aminopeptidase N activity.
Positive_regulation (increase) of aminopeptidase N in T cells
1) Confidence 0.39 Published 1994 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 7910448 Disease Relevance 0 Pain Relevance 0.16
The ApN catalytic activity and mRNA levels are increased in thioglycollate-elicited as compared to resident peritoneal macrophages.
Positive_regulation (increased) of ApN in peritoneal macrophages
2) Confidence 0.35 Published 1994 Journal Regul. Pept. Section Abstract Doc Link 7512741 Disease Relevance 0 Pain Relevance 0.37
The physiological relevance of aminopeptidase N and endopeptidase 24.15 in the heptadecapeptide metabolism remains to be determined.
Positive_regulation (relevance) of aminopeptidase N
3) Confidence 0.23 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 8978746 Disease Relevance 0.06 Pain Relevance 0.66
MCs mature from circulating CD34+, c-kit+, and CD13+progenitors after moving into peripheral tissues [35,53,54].
Positive_regulation (circulating) of CD13
4) Confidence 0.15 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.95 Pain Relevance 0.43
Aminopeptidase activities of venom and purified protein were measured using fluorescent substrates (Leu-AMC to measure APL activity, Arg-AMC to measure APB activity, Ala-AMC to measure APN activity and Glu-AMC and Asp-AMC for APA activity) as previously described [7], [10], [13].
Positive_regulation (measure) of APN
5) Confidence 0.06 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919393 Disease Relevance 0 Pain Relevance 0
Bone marrow aspiration revealed massive proliferation of blasts that were positive for CD13, CD33, CD34, CD56 and myeloperoxidase, and negative for other T-cell, B-cell and monocytic markers.
Positive_regulation (positive) of CD13 in T-cell
6) Confidence 0.05 Published 2001 Journal Acta Haematol. Section Abstract Doc Link 11340253 Disease Relevance 0.52 Pain Relevance 0.07
Bone marrow aspiration revealed massive proliferation of blasts that were positive for CD13, CD33, CD34, CD56 and myeloperoxidase, and negative for other T-cell, B-cell and monocytic markers.
Positive_regulation (positive) of CD13 in B-cell
7) Confidence 0.02 Published 2001 Journal Acta Haematol. Section Abstract Doc Link 11340253 Disease Relevance 0.52 Pain Relevance 0.07

General Comments

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