INT48393

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Context Info
Confidence 0.60
First Reported 1994
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 8.92
Pain Relevance 6.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CSF2) extracellular region (CSF2)
Anatomy Link Frequency
macrophage 6
CSF 2
NK cells 2
epithelial cells 2
PGE2 2
CSF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 47 100.00 Very High Very High Very High
Morphine 3 100.00 Very High Very High Very High
cINOD 37 99.98 Very High Very High Very High
COX2 24 99.86 Very High Very High Very High
aspirin 18 99.86 Very High Very High Very High
epidural 3 99.56 Very High Very High Very High
lidocaine 5 99.24 Very High Very High Very High
Central nervous system 7 98.92 Very High Very High Very High
Potency 4 98.08 Very High Very High Very High
Perioperative pain 2 97.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 52 99.96 Very High Very High Very High
Cancer 284 99.54 Very High Very High Very High
Disease 62 99.34 Very High Very High Very High
Infection 20 99.14 Very High Very High Very High
Systemic Lupus Erythematosus 5 98.76 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 84 98.04 Very High Very High Very High
Post Operative Pain 2 97.36 Very High Very High Very High
INFLAMMATION 234 96.24 Very High Very High Very High
Paralysis 17 96.00 Very High Very High Very High
Toxicity 186 95.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NO-ASA is the exception, because it does not increase GM-CSF release, although at millimolar concentrations cell viability is reduced.
Neg (not) Positive_regulation (increase) of Localization (release) of GM-CSF associated with aspirin
1) Confidence 0.60 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15680249 Disease Relevance 0 Pain Relevance 0.70
NSAIDs increase GM-CSF release by human synoviocytes: comparison with nitric oxide-donating derivatives.
Positive_regulation (increase) of Localization (release) of GM-CSF associated with cinod
2) Confidence 0.60 Published 2005 Journal Eur. J. Pharmacol. Section Title Doc Link 15680249 Disease Relevance 0.19 Pain Relevance 0.93
While animal studies confirm that epidural injection of DepoDur results in the sustained release of morphine into CSF, the CSF pharmacokinetics have not been determined in humans.
Positive_regulation (results) of Localization (release) of CSF in CSF associated with epidural and morphine
3) Confidence 0.52 Published 2006 Journal Clin Pharmacokinet Section Abstract Doc Link 17112293 Disease Relevance 0.41 Pain Relevance 0.97
These drugs may exert part of their therapeutic effect by modulating GM-CSF release.
Positive_regulation (modulating) of Localization (release) of GM-CSF
4) Confidence 0.44 Published 1997 Journal Eur. Respir. J. Section Abstract Doc Link 9230235 Disease Relevance 0.17 Pain Relevance 0.29
Unlike acetylsalicylic acid (ASA), NO-ASA reduces the levels of PGE2, without increasing GM-CSF release, although cell viability is reduced at the highest concentration (1 mM).
Neg (without) Positive_regulation (increasing) of Localization (release) of GM-CSF in PGE2 associated with aspirin
5) Confidence 0.43 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15680249 Disease Relevance 0.15 Pain Relevance 0.90
Passive sensitisation of ASM cells in culture also induced the synthesis and release of GM-CSF, IL-1?
Positive_regulation (induced) of Localization (release) of GM-CSF
6) Confidence 0.18 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.77 Pain Relevance 0.31
Lidocaine also abolished the priming effect of rhG-CSF for enhanced release of O2- in neutrophils and inhibited rhG-CSF-induced CD11b upregulation and LAM-1 downregulation on neutrophils in a dose-dependent manner.
Positive_regulation (enhanced) of Localization (release) of rhG-CSF in neutrophils associated with lidocaine
7) Confidence 0.17 Published 1994 Journal Exp. Hematol. Section Abstract Doc Link 7513653 Disease Relevance 0.24 Pain Relevance 0.69
, granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL12 prior to the first dose, 24 h after each dose, and at 6 and 12 h after the first and fifth dose.
Positive_regulation (macrophage) of Localization (granulocyte) of GM-CSF in macrophage
8) Confidence 0.09 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.54 Pain Relevance 0.06
Increased GM-CSF secretion in the presence of UCLA-OSCCs as compared to UCLA-OSCSCs was more evident in untreated NK cells (Table 2).
Positive_regulation (Increased) of Localization (secretion) of GM-CSF in NK cells
9) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.41 Pain Relevance 0.12
, granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL12 prior to the first dose, 24 h after each dose, and at 6 and 12 h after the first and fifth dose.
Positive_regulation (macrophage) of Localization (granulocyte) of colony-stimulating factor in macrophage
10) Confidence 0.08 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.54 Pain Relevance 0.06
Therefore, from these results a specific profile for NK resistant oral tumors emerged which demonstrated increased GM-CSF, IL-6 and IL-8 secretion in the context of decreased IFN-?
Positive_regulation (increased) of Localization (secretion) of GM-CSF associated with cancer
11) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.59 Pain Relevance 0.06
Net effects on sAPP proteins differ from what is seen in MS, cerebral SLE and CNS infections, since AD patients have unaltered or even elevated CSF levels of ?
Positive_regulation (elevated) of Localization (levels) of CSF associated with central nervous system, disease, systemic lupus erythematosus and infection
12) Confidence 0.06 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2902447 Disease Relevance 2.40 Pain Relevance 0.23
At a much lower level a similar effect was observed for GRO, G-CSF, IL-8, IL-1?
Positive_regulation (level) of Localization (observed) of G-CSF
13) Confidence 0.06 Published 2010 Journal Respir Res Section Body Doc Link PMC2923116 Disease Relevance 0.15 Pain Relevance 0.37
Human tumors, including lymphomas, secrete chemokines such as monocyte chemotactic protein-1 (MCP-1), macrophage colony stimulating factor (M-CSF), and VEGF, which are believed to be important for the recruitment of macrophages into tumor sites [26], [27].
Positive_regulation (macrophage) of Localization (secrete) of colony stimulating factor in macrophages associated with chemokine, lymphatic system cancer and cancer
14) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780293 Disease Relevance 1.89 Pain Relevance 0.09
Acetylcholine is also known to induce the release of GM-CSF from human bronchial epithelial cells by a mechanism that involves nicotinic receptors [97].
Positive_regulation (induce) of Localization (release) of GM-CSF in epithelial cells
15) Confidence 0.01 Published 2006 Journal Respir Res Section Body Doc Link PMC1479816 Disease Relevance 0.49 Pain Relevance 0.30

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