INT48394

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Context Info
Confidence 0.40
First Reported 1994
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.49
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (SELL) plasma membrane (SELL)
Anatomy Link Frequency
neutrophils 4
SELL (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 10 99.98 Very High Very High Very High
local anesthetic 4 99.78 Very High Very High Very High
Inflammation 4 77.92 Quite High
cytokine 2 72.72 Quite High
Disease Link Frequency Relevance Heat
Adhesions 6 90.88 High High
INFLAMMATION 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cationic local anesthetic lidocaine inhibited not only FMLP-induced O2- release in neutrophils but also FMLP-induced CD11b upregulation and LAM-1 downregulation on neutrophils in a dose-dependent manner.
Negative_regulation (inhibited) of Negative_regulation (downregulation) of LAM-1 in neutrophils associated with lidocaine and local anesthetic
1) Confidence 0.40 Published 1994 Journal Exp. Hematol. Section Abstract Doc Link 7513653 Disease Relevance 0.25 Pain Relevance 0.67
Lidocaine also abolished the priming effect of rhG-CSF for enhanced release of O2- in neutrophils and inhibited rhG-CSF-induced CD11b upregulation and LAM-1 downregulation on neutrophils in a dose-dependent manner.
Negative_regulation (inhibited) of Negative_regulation (downregulation) of LAM-1 in neutrophils associated with lidocaine
2) Confidence 0.40 Published 1994 Journal Exp. Hematol. Section Abstract Doc Link 7513653 Disease Relevance 0.24 Pain Relevance 0.71

General Comments

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