INT484

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Context Info
Confidence 0.59
First Reported 1979
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 2.85
Pain Relevance 3.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ADRB2) plasma membrane (ADRB2) nucleus (ADRB2)
lysosome (ADRB2) cytoplasm (ADRB2) signal transducer activity (ADRB2)
Anatomy Link Frequency
myometrium 1
plasma 1
nerve 1
heart 1
ADRB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 29 100.00 Very High Very High Very High
Clonidine 6 100.00 Very High Very High Very High
Potency 7 99.48 Very High Very High Very High
noradrenaline 2 99.42 Very High Very High Very High
depression 5 98.86 Very High Very High Very High
Catecholamine 10 98.24 Very High Very High Very High
beta blocker 2 98.16 Very High Very High Very High
narcan 7 98.10 Very High Very High Very High
local anesthetic 18 97.36 Very High Very High Very High
antagonist 21 97.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Arrhythmias 2 Under Development 4 99.92 Very High Very High Very High
Overdose 2 99.62 Very High Very High Very High
Myocardial Infarction 2 99.28 Very High Very High Very High
Cardiovascular Disorder Under Development 2 98.86 Very High Very High Very High
Sudden Death 1 97.96 Very High Very High Very High
Paraganglioma 2 97.78 Very High Very High Very High
Bradycardia 2 96.92 Very High Very High Very High
Sleep Disorders 2 94.00 High High
Cv General 3 Under Development 12 93.64 High High
Depression 3 92.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Beta-blockers, particularly propranolol and metoprolol, with which we have the most experience, work via beta 2 adrenoceptor blockade in the heart.
Negative_regulation (blockade) of beta 2 adrenoceptor in heart associated with beta blocker
1) Confidence 0.59 Published 1983 Journal Arch Mal Coeur Vaiss Section Abstract Doc Link 6134510 Disease Relevance 0.64 Pain Relevance 0.64
Finally, the relatively potent inhibition of beta2ARs by etidocaine, tetracaine, and bupivacaine suggests that their propensity for cardiovascular depression after accidental intravenous overdose could result from beta2AR or beta1AR blockade and inhibition of cAMP production.
Negative_regulation (blockade) of beta2AR associated with depression, overdose and cardiovascular disorder under development
2) Confidence 0.57 Published 1997 Journal Anesth. Analg. Section Abstract Doc Link 9249110 Disease Relevance 0.20 Pain Relevance 0.85
Densitometric analysis of the RT-PCR experiments indicated a slight decrease in the signal for ADRB2 mRNA (-27.4%) in near-term myometrium comparatively to non-pregnant tissue whereas the signal for ADRB3 mRNA was increased in pregnant myometrium (+66.3%).
Negative_regulation (decrease) of ADRB2 in myometrium
3) Confidence 0.43 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892055 Disease Relevance 0 Pain Relevance 0.07
The structure-activity relationship between the acute nonspecific cardiovascular depressant effects of the beta-adrenoceptor blocking drugs and their hydrophobic properties was evaluated experimentally for propranolol, pindolol, practolol, and atenolol, in the anaesthetized cat after preceding beta-adrenoceptor blockade.
Negative_regulation (blockade) of beta-adrenoceptor
4) Confidence 0.43 Published 1984 Journal Arzneimittelforschung Section Abstract Doc Link 6150722 Disease Relevance 0.22 Pain Relevance 0.05
Acutely dissociated cells could be used to study the beta-adrenergic receptor adenylyl cyclase system since they produced cAMP in response to isoproterenol.
Negative_regulation (study) of beta-adrenergic receptor adenylyl cyclase
5) Confidence 0.43 Published 1992 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 1320903 Disease Relevance 0 Pain Relevance 0.13
The correlation between increased inhibition of beta2AR binding and alkyl chain length resembles the correlation between local anesthetic potency at nerve block and increased alkyl chain length.
Negative_regulation (inhibition) of beta2AR in nerve associated with nerve block, potency and local anesthetic
6) Confidence 0.42 Published 1997 Journal Anesth. Analg. Section Abstract Doc Link 9249110 Disease Relevance 0.13 Pain Relevance 0.87
Experimental evidence and role of beta-adrenoceptor blockade.
Negative_regulation (blockade) of beta-adrenoceptor
7) Confidence 0.41 Published 1979 Journal S. Afr. Med. J. Section Title Doc Link 42151 Disease Relevance 0.55 Pain Relevance 0.22
Pithing or beta-adrenoceptor blockade reduced the potency of ouabain for producing arrhythmias, but bilateral adrenalectomy did not give protection.
Negative_regulation (blockade) of beta-adrenoceptor associated with potency
8) Confidence 0.41 Published 1982 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6122584 Disease Relevance 0.32 Pain Relevance 0.28
In three out of four patients with confirmed phaeochromocytomas or paragangliomas, 10 mg naloxone resulted in a marked rise (290-575%) in circulating noradrenaline; despite combined alpha and beta-adrenoceptor blockade, in two out of four cases systolic and diastolic pressures rose whilst pulse rate fell.
Negative_regulation (blockade) of beta-adrenoceptor associated with noradrenaline, narcan and paraganglioma
9) Confidence 0.41 Published 1986 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 3708878 Disease Relevance 0.25 Pain Relevance 0.47
Maximal heart rate was slightly higher amongst patients (P < 0.05), despite similar loads and plasma catecholamine responses to exercise in the two groups; this difference disappeared after beta-adrenoceptor blockade with propranolol.
Negative_regulation (blockade) of beta-adrenoceptor in plasma
10) Confidence 0.35 Published 2007 Journal J. Intern. Med. Section Body Doc Link 17241180 Disease Relevance 0.05 Pain Relevance 0
ADRB2 receptors are positively coupled to G?
Negative_regulation (receptors) of ADRB2
11) Confidence 0.32 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892059 Disease Relevance 0 Pain Relevance 0.05
The central noradrenergic system is believed to play a role in the maintenance of alertness, and there is evidence that alpha 2-adrenoceptor agonists (e.g. clonidine) decrease the activity of central noradrenergic neurones, whereas alpha 2-adrenoceptor antagonists (e.g. yohimbine) have the opposite effect.
Negative_regulation (decrease) of 2-adrenoceptor associated with antagonist, agonist and clonidine
12) Confidence 0.31 Published 2000 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 10867980 Disease Relevance 0.18 Pain Relevance 0.27
2 = 0.77; P = 0.38) or beta adrenoceptor blockers (22/24 versus 18/24: ?
Negative_regulation (blockers) of beta adrenoceptor
13) Confidence 0.06 Published 2008 Journal Atherosclerosis Section Body Doc Link PMC2292239 Disease Relevance 0.31 Pain Relevance 0.04

General Comments

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