INT4840

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Context Info
Confidence 0.69
First Reported 1992
Last Reported 1995
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 0.79
Pain Relevance 6.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npff) extracellular region (Npff)
Anatomy Link Frequency
spinal cord 6
nerve 2
Npff (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 30 99.98 Very High Very High Very High
Morphine 14 99.98 Very High Very High Very High
Spinal cord 32 99.60 Very High Very High Very High
narcan 8 99.28 Very High Very High Very High
tetrodotoxin 5 99.00 Very High Very High Very High
conotoxin 3 97.56 Very High Very High Very High
opioid receptor 8 94.64 High High
Hyperalgesia 5 91.56 High High
analgesia 7 90.32 High High
Pain threshold 3 90.12 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 5 91.56 High High
Pain 9 90.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further studies with substance P-related peptides showed that the in vitro release of NPFF-IR could also be induced by substance P (1-7) but not by [pGlu5,Me-Phe8,Sar9]-substance P (5-11) or substance K.
Neg (not) Positive_regulation (induced) of Localization (release) of NPFF-IR associated with substance p
1) Confidence 0.69 Published 1992 Journal Brain Res. Section Abstract Doc Link 1280519 Disease Relevance 0.07 Pain Relevance 0.99
We also showed that NPFF release was a function of the extent of depolarization and was calcium dependent.
Positive_regulation (dependent) of Localization (release) of NPFF
2) Confidence 0.50 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7891084 Disease Relevance 0.08 Pain Relevance 0.65
These results suggest that the specific substance P receptor (SP-N), which is recognized by both substance P (1-11) and substance P (1-7) rather than the tachykinin receptor, is involved in NPFF secretion from the spinal cord.
Positive_regulation (involved) of Localization (secretion) of NPFF in spinal cord associated with spinal cord and substance p
3) Confidence 0.44 Published 1992 Journal Brain Res. Section Abstract Doc Link 1280519 Disease Relevance 0.06 Pain Relevance 0.97
In contrast, omega-agatoxin IVA (1 microM) led to a 65% reduction in NPFF release, suggesting that P-type Ca2+ channels play a prominent role.
Positive_regulation (led) of Localization (release) of NPFF
4) Confidence 0.41 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7891084 Disease Relevance 0.07 Pain Relevance 0.59
The opening of voltage-sensitive Na+ channels with veratridine (20 microM) induced calcium-dependent NPFF release, which was abolished by tetrodotoxin (1 microM), suggesting that NPFF release depends on nerve impulse activity.
Positive_regulation (induced) of Localization (release) of NPFF in nerve associated with tetrodotoxin
5) Confidence 0.41 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7891084 Disease Relevance 0.09 Pain Relevance 0.64
The present experiments, using an in vitro superfusion of an isolated whole rat spinal cord, demonstrated that high concentrations of KCl or substance P caused a release of NPFF immunoreactive material (IR) from the spinal cord into the perfusion medium in a calcium-dependent manner.
Positive_regulation (caused) of Localization (release) of NPFF in spinal cord associated with substance p and spinal cord
6) Confidence 0.40 Published 1992 Journal Brain Res. Section Abstract Doc Link 1280519 Disease Relevance 0.09 Pain Relevance 0.73
The morphine-induced release of NPFF was abolished by naloxone (1 microM) but unaltered by tetrodotoxin.
Positive_regulation (induced) of Localization (release) of NPFF associated with tetrodotoxin, narcan and morphine
7) Confidence 0.40 Published 1995 Journal Brain Res. Section Abstract Doc Link 8624708 Disease Relevance 0.16 Pain Relevance 1.11
First, by using in vitro superfusion system with rat spinal cord slices, we showed that morphine stimulated NPFF release in a dose-dependent manner.
Positive_regulation (stimulated) of Localization (release) of NPFF in spinal cord associated with morphine and spinal cord
8) Confidence 0.40 Published 1995 Journal Brain Res. Section Abstract Doc Link 8624708 Disease Relevance 0.16 Pain Relevance 1.01

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