INT48406

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Context Info
Confidence 0.78
First Reported 1993
Last Reported 2011
Negated 3
Speculated 17
Reported most in Abstract
Documents 277
Total Number 298
Disease Relevance 238.28
Pain Relevance 81.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Icam1) cell adhesion (Icam1) plasma membrane (Icam1)
Anatomy Link Frequency
plasma 20
neutrophil 18
endothelial cells 16
leukocyte 14
brain 9
Icam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 2287 100.00 Very High Very High Very High
cytokine 802 100.00 Very High Very High Very High
chemokine 207 100.00 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 162 100.00 Very High Very High Very High
Angina 275 99.92 Very High Very High Very High
interstitial cystitis 66 99.84 Very High Very High Very High
aspirin 63 99.84 Very High Very High Very High
Chronic pancreatitis 61 99.84 Very High Very High Very High
IPN 60 99.82 Very High Very High Very High
cINOD 163 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2555 100.00 Very High Very High Very High
Adhesions 1365 100.00 Very High Very High Very High
Cancer 620 100.00 Very High Very High Very High
Necrosis 285 100.00 Very High Very High Very High
Urological Neuroanatomy 151 100.00 Very High Very High Very High
Arthritis 57 100.00 Very High Very High Very High
Hepatocellular Cancer 10 100.00 Very High Very High Very High
Uveitis 127 99.98 Very High Very High Very High
Cv General 3 Under Development 304 99.92 Very High Very High Very High
Diabetic Retinopathy 53 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Indomethacin-induced damage in healthy and arthritic rats is largely dependent on ICAM-1 expression.
Gene_expression (expression) of ICAM-1
1) Confidence 0.78 Published 1995 Journal Gastroenterology Section Body Doc Link 7557083 Disease Relevance 0.11 Pain Relevance 0
Results showed an early increase in ICAM-1 RNA and protein expression after CIP with no change in circulating levels of several proinflammatory cytokines.
Gene_expression (expression) of ICAM-1 RNA associated with ipn and cytokine
2) Confidence 0.78 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16199477 Disease Relevance 0.87 Pain Relevance 1.10
The current study investigated effects of lambda-carrageenan-induced inflammatory pain (CIP) on BBB expression of ICAM-1.
Gene_expression (expression) of ICAM-1 associated with ipn
3) Confidence 0.78 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16199477 Disease Relevance 0.76 Pain Relevance 0.94
Changes in ICAM-1 protein expression were noted at 48 h.
Gene_expression (expression) of ICAM-1
4) Confidence 0.78 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16199477 Disease Relevance 0.84 Pain Relevance 1.06
We investigated ICAM-1 RNA and protein expression levels in isolated rat brain microvessels after CIP using RT-PCR and Western blot analyses, screened inflammatory cytokines during the time course of inflammation, assessed white blood cell counts, and probed for BBB and central nervous system stimulation and leukocyte transmigration using immunohistochemistry and flow cytometry.
Spec (investigated) Gene_expression (expression) of ICAM-1 RNA in leukocyte associated with inflammation, ipn, central nervous system and cytokine
5) Confidence 0.78 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16199477 Disease Relevance 0.87 Pain Relevance 1.07
Therefore, we evaluated ICAM-1 expression and the effect of anti-ICAM-1 treatment on motor recovery and neutrophil invasion after traumatic brain injury induced via the lateral fluid-percussion method in the rat.
Gene_expression (expression) of ICAM-1 in neutrophil associated with brain injury
6) Confidence 0.78 Published 2002 Journal J. Neurotrauma Section Abstract Doc Link 12482117 Disease Relevance 0.86 Pain Relevance 0.05
ICAM-1 expression correlates with the severity of clinical head injuries, but its importance in secondary injury events is not fully understood.
Gene_expression (expression) of ICAM-1 in head associated with injury and brain injury
7) Confidence 0.78 Published 2002 Journal J. Neurotrauma Section Abstract Doc Link 12482117 Disease Relevance 0.84 Pain Relevance 0.05
ICAM-1 was expressed in large and small blood vessels within the injured cortex at 10 and 24 h after injury.
Gene_expression (expressed) of ICAM-1 in cortex associated with injury
8) Confidence 0.78 Published 2002 Journal J. Neurotrauma Section Abstract Doc Link 12482117 Disease Relevance 0.92 Pain Relevance 0.04
ICAM-1 expression was quantified using monoclonal antibodies against rat ICAM-1 that bind to the endothelium in proportion to the degree of adhesion molecule expression.
Gene_expression (expression) of ICAM-1 in endothelium
9) Confidence 0.78 Published 1998 Journal J. Rheumatol. Section Body Doc Link 9517771 Disease Relevance 0.16 Pain Relevance 0
OBJECTIVE: To quantify intercellular adhesion molecule-1 (ICAM-1) expression in normal and adjuvant arthritic rats and to determine the extent to which ICAM-1 expression in arthritic animals is altered by treatment with a prototype nonsteroidal antiinflammatory drug (NSAID) and a kappa-opioid agonist.
Gene_expression (expression) of ICAM-1 associated with mu agonist, inflammation, cinod, arthritis and adhesions
10) Confidence 0.78 Published 1998 Journal J. Rheumatol. Section Abstract Doc Link 9517771 Disease Relevance 0.54 Pain Relevance 0.38
Intercellular adhesion molecule-1 expression in adjuvant arthritis in rats: inhibition by kappa-opioid agonist but not by NSAID.
Gene_expression (expression) of Intercellular adhesion molecule-1 associated with mu agonist, cinod, experimental arthritis, adhesions and arthritis
11) Confidence 0.78 Published 1998 Journal J. Rheumatol. Section Title Doc Link 9517771 Disease Relevance 0.39 Pain Relevance 0.42
OBJECTIVE: To quantify intercellular adhesion molecule-1 (ICAM-1) expression in normal and adjuvant arthritic rats and to determine the extent to which ICAM-1 expression in arthritic animals is altered by treatment with a prototype nonsteroidal antiinflammatory drug (NSAID) and a kappa-opioid agonist.
Gene_expression (expression) of intercellular adhesion molecule-1 associated with mu agonist, inflammation, cinod, arthritis and adhesions
12) Confidence 0.78 Published 1998 Journal J. Rheumatol. Section Abstract Doc Link 9517771 Disease Relevance 0.54 Pain Relevance 0.37
In animals treated with PD 117302 and naproxen there was a significant attenuation of arthritis; however, only treatment with PD117302 was able to significantly inhibit the upregulation of ICAM-1 expression in arthritic joints.
Gene_expression (expression) of ICAM-1 in joints
13) Confidence 0.78 Published 1998 Journal J. Rheumatol. Section Body Doc Link 9517771 Disease Relevance 0.12 Pain Relevance 0
CONCLUSION: ICAM-1 expression is upregulated in experimental arthritis.
Gene_expression (expression) of ICAM-1
14) Confidence 0.78 Published 1998 Journal J. Rheumatol. Section Body Doc Link 9517771 Disease Relevance 0.11 Pain Relevance 0
OBJECTIVE: To quantify intercellular adhesion molecule-1 (ICAM-1) expression in normal and adjuvant arthritic rats and to determine the extent to which ICAM-1 expression in arthritic animals is altered by treatment with a prototype nonsteroidal antiinflammatory drug (NSAID) and a kappa-opioid agonist.
Gene_expression (expression) of ICAM-1 associated with mu agonist, inflammation, cinod, arthritis and adhesions
15) Confidence 0.78 Published 1998 Journal J. Rheumatol. Section Abstract Doc Link 9517771 Disease Relevance 0.54 Pain Relevance 0.37
RESULTS: ICAM-1 expression was significantly upregulated in the joints of affected limbs of animals with both unilateral hind paw inflammation and polyarthritis.
Gene_expression (expression) of ICAM-1 in paw
16) Confidence 0.78 Published 1998 Journal J. Rheumatol. Section Body Doc Link 9517771 Disease Relevance 0.14 Pain Relevance 0
Gastric mucosal vascular expression of intercellular adhesion molecule 1 (ICAM-1) or P-selectin were determined at 1 and 3 h after Indo administration using the dual radiolabeled monoclonal antibody (MAb) technique.
Spec (determined) Gene_expression (expression) of ICAM-1 associated with adhesions
17) Confidence 0.77 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9486176 Disease Relevance 0.46 Pain Relevance 0.32
Gastric mucosal vascular expression of intercellular adhesion molecule 1 (ICAM-1) or P-selectin were determined at 1 and 3 h after Indo administration using the dual radiolabeled monoclonal antibody (MAb) technique.
Spec (determined) Gene_expression (expression) of intercellular adhesion molecule 1 associated with adhesions
18) Confidence 0.77 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9486176 Disease Relevance 0.46 Pain Relevance 0.32
We found that P-selectin expression was significantly increased at 1 h but not 3 h after Indo administration, whereas ICAM-1 expression was significantly increased at both 1 and 3 h after Indo treatment.
Gene_expression (expression) of ICAM-1
19) Confidence 0.77 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9486176 Disease Relevance 0.57 Pain Relevance 0.38
ICAM-1 and P-selectin expression in a model of NSAID-induced gastropathy.
Gene_expression (expression) of ICAM-1 associated with cinod
20) Confidence 0.77 Published 1998 Journal Am. J. Physiol. Section Title Doc Link 9486176 Disease Relevance 0.39 Pain Relevance 0.36

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