INT48407

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1993
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 61
Total Number 65
Disease Relevance 57.91
Pain Relevance 21.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Icam1) cell adhesion (Icam1) plasma membrane (Icam1)
Anatomy Link Frequency
neutrophils 10
endothelial cells 7
plasma 6
brain 4
vessels 4
Icam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 509 100.00 Very High Very High Very High
cytokine 172 100.00 Very High Very High Very High
chemokine 33 100.00 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 27 100.00 Very High Very High Very High
IPN 16 99.98 Very High Very High Very High
Angina 57 99.92 Very High Very High Very High
Chronic pancreatitis 45 99.92 Very High Very High Very High
cva 93 99.82 Very High Very High Very High
nMDA receptor 8 99.36 Very High Very High Very High
cINOD 43 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 565 100.00 Very High Very High Very High
Adhesions 294 100.00 Very High Very High Very High
Apoptosis 177 100.00 Very High Very High Very High
Sepsis 77 100.00 Very High Very High Very High
Uveitis 84 99.98 Very High Very High Very High
Inflammatory Pain 16 99.98 Very High Very High Very High
Adult Respiratory Distress Syndrome 144 99.96 Very High Very High Very High
Cv General 3 Under Development 57 99.92 Very High Very High Very High
Pancreatitis 54 99.92 Very High Very High Very High
Myocardial Infarction 53 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results showed an early increase in ICAM-1 RNA and protein expression after CIP with no change in circulating levels of several proinflammatory cytokines.
Positive_regulation (increase) of Gene_expression (expression) of ICAM-1 RNA associated with ipn and cytokine
1) Confidence 0.70 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16199477 Disease Relevance 0.88 Pain Relevance 1.10
RESULTS: ICAM-1 expression was significantly upregulated in the joints of affected limbs of animals with both unilateral hind paw inflammation and polyarthritis.
Positive_regulation (upregulated) of Gene_expression (expression) of ICAM-1 in paw
2) Confidence 0.69 Published 1998 Journal J. Rheumatol. Section Body Doc Link 9517771 Disease Relevance 0.14 Pain Relevance 0
In animals treated with PD 117302 and naproxen there was a significant attenuation of arthritis; however, only treatment with PD117302 was able to significantly inhibit the upregulation of ICAM-1 expression in arthritic joints.
Positive_regulation (upregulation) of Gene_expression (expression) of ICAM-1 in joints
3) Confidence 0.69 Published 1998 Journal J. Rheumatol. Section Body Doc Link 9517771 Disease Relevance 0.12 Pain Relevance 0
CONCLUSION: ICAM-1 expression is upregulated in experimental arthritis.
Positive_regulation (upregulated) of Gene_expression (expression) of ICAM-1
4) Confidence 0.69 Published 1998 Journal J. Rheumatol. Section Body Doc Link 9517771 Disease Relevance 0.11 Pain Relevance 0
We found that P-selectin expression was significantly increased at 1 h but not 3 h after Indo administration, whereas ICAM-1 expression was significantly increased at both 1 and 3 h after Indo treatment.
Positive_regulation (increased) of Gene_expression (expression) of ICAM-1
5) Confidence 0.69 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9486176 Disease Relevance 0.58 Pain Relevance 0.39
This increase in ICAM-1 expression may be associated with an inhibition of prostaglandin synthesis by NSAIDs.
Positive_regulation (increase) of Gene_expression (expression) of ICAM-1 associated with cinod
6) Confidence 0.68 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7513960 Disease Relevance 0.35 Pain Relevance 0.65
Endotoxin caused a two- to threefold increase in ICAM-1 expression in the stomach and duodenum.
Positive_regulation (increase) of Gene_expression (expression) of ICAM-1 in stomach
7) Confidence 0.68 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16020654 Disease Relevance 0.29 Pain Relevance 0.09
Incubation of LT4 and ECV304 cells with interleukin-1beta or TNF-alpha produced a significant increase in ICAM-1 expression on their cell surface (ranging from a 2-fold increase for interleukin-1beta to a 5-fold increase for TNF-alpha).
Positive_regulation (increase) of Gene_expression (expression) of ICAM-1 in ECV304
8) Confidence 0.60 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9274931 Disease Relevance 0.43 Pain Relevance 0.46
In the current article, we emphasized overexpression of ICAM-1 by endothelial cells and inflammatory cells in EIU, suggesting a probable active inflammatory cell aggregation mechanism against the endothelium to form keratic precipitates.
Positive_regulation (overexpression) of Gene_expression (overexpression) of ICAM-1 in endothelium associated with inflammation and uveitis
9) Confidence 0.60 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2435159 Disease Relevance 1.07 Pain Relevance 0.20
Increased expression of sICAM-1 was associated with augmented systemic secretion of cytokines.
Positive_regulation (Increased) of Gene_expression (expression) of sICAM-1 associated with cytokine
10) Confidence 0.56 Published 2002 Journal Kardiologiia Section Abstract Doc Link 12494066 Disease Relevance 1.02 Pain Relevance 0.63
Therefore, we evaluated ICAM-1 expression and the effect of anti-ICAM-1 treatment on motor recovery and neutrophil invasion after traumatic brain injury induced via the lateral fluid-percussion method in the rat.
Positive_regulation (evaluated) of Gene_expression (expression) of ICAM-1 in neutrophil associated with brain injury
11) Confidence 0.50 Published 2002 Journal J. Neurotrauma Section Abstract Doc Link 12482117 Disease Relevance 0.86 Pain Relevance 0.05
The findings of the present study were that CIP induces increased ICAM-1 mRNA and protein expression at the BBB and that systemic proinflammatory mediators play no apparent role in the early response (1-6 h); however, brain region-specific increases in microglial activation suggest a potential for a central-mediated response.
Positive_regulation (induces) of Gene_expression (expression) of ICAM-1 mRNA in brain associated with ipn
12) Confidence 0.47 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16199477 Disease Relevance 0.70 Pain Relevance 0.80
Stimulation of ICAM expression is mediated by activation of the transcription factor NF-kappaB.
Positive_regulation (Stimulation) of Gene_expression (expression) of ICAM
13) Confidence 0.46 Published 1999 Journal Gastroenterology Section Abstract Doc Link 10092308 Disease Relevance 0.44 Pain Relevance 0.26
Indomethacin stimulates tumor necrosis factor (TNF)-alpha expression, which may enhance adhesiveness of gastric capillaries for neutrophils by activating ICAM expression on endothelial cells.
Positive_regulation (activating) of Gene_expression (expression) of ICAM in endothelial cells associated with necrosis and cancer
14) Confidence 0.46 Published 1999 Journal Gastroenterology Section Abstract Doc Link 10092308 Disease Relevance 0.46 Pain Relevance 0.26
CONCLUSIONS: Indomethacin-induced gastric injury and increased ICAM expression are inhibited by inhibition of the proteasome.


Positive_regulation (increased) of Gene_expression (expression) of ICAM
15) Confidence 0.46 Published 1999 Journal Gastroenterology Section Body Doc Link 10092308 Disease Relevance 0 Pain Relevance 0
number of ICAM-1-positive vessels was significantly increased as compared with
Positive_regulation (increased) of Gene_expression (vessels) of ICAM-1-positive in vessels
16) Confidence 0.45 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2375967 Disease Relevance 0.86 Pain Relevance 0.08
Following one week of diabetes, neutrophil CD11a, CD11b, and CD18 expression was increased significantly, as were retinal ICAM-1 levels.
Positive_regulation (increased) of Gene_expression (levels) of ICAM-1 in neutrophil associated with diabetes mellitus
17) Confidence 0.45 Published 2002 Journal FASEB J. Section Abstract Doc Link 11821258 Disease Relevance 1.13 Pain Relevance 0.51
, caspase-3, type III procollagen (PCIII), intercellular adhesion molecule 1 (ICAM-1), and vascular cell adhesion molecule 1 (VCAM-1) mRNA expressions in lung tissue, as well as lung and distal organ epithelial cell apoptosis in an experimental model of sepsis-induced ALI.


Positive_regulation (induced) of Gene_expression (expressions) of intercellular adhesion molecule in epithelial cell associated with adult respiratory distress syndrome, apoptosis, sepsis and adhesions
18) Confidence 0.44 Published 2010 Journal Crit Care Section Body Doc Link PMC2911760 Disease Relevance 1.73 Pain Relevance 0
, caspase-3, type III procollagen (PCIII), intercellular adhesion molecule 1 (ICAM-1), and vascular cell adhesion molecule 1 (VCAM-1) mRNA expressions in lung tissue, as well as lung and distal organ epithelial cell apoptosis in an experimental model of sepsis-induced ALI.


Positive_regulation (induced) of Gene_expression (expressions) of ICAM-1 in epithelial cell associated with adult respiratory distress syndrome, apoptosis, sepsis and adhesions
19) Confidence 0.44 Published 2010 Journal Crit Care Section Body Doc Link PMC2911760 Disease Relevance 1.71 Pain Relevance 0
Incubation of LT4 and ECV304 cells with interleukin-1beta or TNF-alpha produced a significant increase in ICAM-1 expression on their cell surface (ranging from a 2-fold increase for interleukin-1beta to a 5-fold increase for TNF-alpha).
Positive_regulation (increase) of Gene_expression (expression) of ICAM-1 in ECV304
20) Confidence 0.44 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9274931 Disease Relevance 0.43 Pain Relevance 0.46

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox