INT48408

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1994
Last Reported 2011
Negated 4
Speculated 20
Reported most in Abstract
Documents 494
Total Number 514
Disease Relevance 340.08
Pain Relevance 88.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ICAM1) cell adhesion (ICAM1) plasma membrane (ICAM1)
Anatomy Link Frequency
endothelial cells 46
neutrophil 27
leukocytes 23
monocytes 15
Caco-2 13
ICAM1 (Homo sapiens)
ICAM1 - K469E (1)
Pain Link Frequency Relevance Heat
Inflammation 7284 100.00 Very High Very High Very High
cytokine 3797 100.00 Very High Very High Very High
chemokine 517 100.00 Very High Very High Very High
Inflammatory mediators 268 100.00 Very High Very High Very High
antagonist 237 100.00 Very High Very High Very High
dexamethasone 687 99.90 Very High Very High Very High
substance P 119 99.86 Very High Very High Very High
lidocaine 60 99.84 Very High Very High Very High
Migraine 43 99.84 Very High Very High Very High
ischemia 223 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 8296 100.00 Very High Very High Very High
Adhesions 7741 100.00 Very High Very High Very High
Cancer 2128 100.00 Very High Very High Very High
Coronary Artery Disease 536 100.00 Very High Very High Very High
Necrosis 488 100.00 Very High Very High Very High
Chronic Fatigue Syndrome 31 100.00 Very High Very High Very High
Fowlpox 20 100.00 Very High Very High Very High
Polymyalgia Rheumatica 114 99.92 Very High Very High Very High
Nicotine Addiction 10239 99.84 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 618 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Culture for 24 h with rIFN-gamma resulted in a significant increase in ICAM-1 protein expression (82% of cells were strongly positive).
Gene_expression (expression) of ICAM-1
1) Confidence 0.78 Published 1996 Journal Eur. Respir. J. Section Abstract Doc Link 8730005 Disease Relevance 0.28 Pain Relevance 0.25
By contrast, dexamethasone did not influence rIFN-gamma-induced ICAM-1 expression.
Gene_expression (expression) of ICAM-1 associated with dexamethasone
2) Confidence 0.78 Published 1996 Journal Eur. Respir. J. Section Abstract Doc Link 8730005 Disease Relevance 0.18 Pain Relevance 0.26
ICAM-1 protein expression was studied on AMs by means of flow cytometry with an anti-CD54 monoclonal antibody; messenger ribonucleic acid (mRNA) levels were determined by reverse transcriptase-polymerase chain reaction (RT-PCR).
Gene_expression (expression) of ICAM-1 in AMs
3) Confidence 0.78 Published 1996 Journal Eur. Respir. J. Section Abstract Doc Link 8730005 Disease Relevance 0.35 Pain Relevance 0.18
Modulation of ICAM-1 expression in human alveolar macrophages in vitro.
Gene_expression (expression) of ICAM-1 in alveolar macrophages
4) Confidence 0.78 Published 1996 Journal Eur. Respir. J. Section Title Doc Link 8730005 Disease Relevance 0.36 Pain Relevance 0.17
Modulation of intercellular adhesion molecule-1 (ICAM-1) expression may be a basic mechanism by which alveolar macrophages (AMs) regulate the inflammatory process in the lung in response to local stimuli.
Gene_expression (expression) of ICAM-1 in alveolar macrophages associated with inflammation and adhesions
5) Confidence 0.78 Published 1996 Journal Eur. Respir. J. Section Abstract Doc Link 8730005 Disease Relevance 0.36 Pain Relevance 0.16
Fusafungine significantly inhibited rIFN-gamma-induced ICAM-1-protein expression on AMs in a concentration-dependent fashion.
Gene_expression (expression) of ICAM-1-protein in AMs
6) Confidence 0.78 Published 1996 Journal Eur. Respir. J. Section Abstract Doc Link 8730005 Disease Relevance 0.26 Pain Relevance 0.26
As a model for studying the anti-inflammatory activity of drugs on human AMs, we investigated the effects of fusafungine, an antibiotic for local use by aerosol with anti-inflammatory properties, and that of the glucocorticoid dexamethasone, on ICAM-1 expression induced in vitro by recombinant interferon-gamma (rIFN-gamma).
Gene_expression (expression) of ICAM-1 in AMs associated with inflammation and dexamethasone
7) Confidence 0.78 Published 1996 Journal Eur. Respir. J. Section Abstract Doc Link 8730005 Disease Relevance 0.37 Pain Relevance 0.19
ICAM-1 was expressed before culture on 21% of bronchoalveolar lavage (BAL) cells, with low intensity.
Gene_expression (expressed) of ICAM-1
8) Confidence 0.78 Published 1996 Journal Eur. Respir. J. Section Abstract Doc Link 8730005 Disease Relevance 0.31 Pain Relevance 0.20
Previously, it was demonstrated that immunoliposomes, bearing anti-intercellular adhesion molecule-1 (ICAM-1) antibodies (mAb F10.2), can specifically bind to different cell types expressing ICAM-1.
Gene_expression (expressing) of ICAM-1 associated with adhesions
9) Confidence 0.78 Published 1999 Journal Biochim. Biophys. Acta Section Abstract Doc Link 10407086 Disease Relevance 0.17 Pain Relevance 0
The results indicate that ICAM-1 targeted immunoliposomes may be used as carriers for the intracellular delivery of anti-inflammatory drugs to sites of inflammation characterised by an increased expression of ICAM-1.
Gene_expression (expression) of ICAM-1 associated with inflammation and cinod
10) Confidence 0.78 Published 1999 Journal Biochim. Biophys. Acta Section Abstract Doc Link 10407086 Disease Relevance 0.34 Pain Relevance 0.15
HA binds to lymphocytes and endothelial cells expressing ICAM-1.
Gene_expression (expressing) of ICAM in endothelial cells
11) Confidence 0.78 Published 2002 Journal Urology Section Abstract Doc Link 12100920 Disease Relevance 0.25 Pain Relevance 0.16
OBJECTIVES: To study the clinical effect of diagnostic overdistension plus hyaluronic acid (HA) instillations in interstitial cystitis and the association of the clinical response with the intensity of intercellular adhesion molecule (ICAM)-1 expression.
Gene_expression (expression) of intercellular adhesion molecule associated with interstitial cystitis and adhesions
12) Confidence 0.78 Published 2002 Journal Urology Section Abstract Doc Link 12100920 Disease Relevance 0.27 Pain Relevance 0.17
These results indicate that neuropeptides such as SP are capable of directly activating HDMEC to express increased levels of functional ICAM-1 and further support the role of the cutaneous neurological system in modulating inflammatory processes in the skin.
Gene_expression (express) of ICAM-1 in skin associated with inflammation, neuropeptide and substance p
13) Confidence 0.77 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9843720 Disease Relevance 0.22 Pain Relevance 0.51
We examined the direct effect of SP on human dermal microvascular endothelial cell (HDMEC) intercellular adhesion molecule 1 (ICAM-1) expression and function.
Gene_expression (expression) of ICAM-1 in endothelial cell associated with adhesions and substance p
14) Confidence 0.77 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9843720 Disease Relevance 0.19 Pain Relevance 0.35
We examined the direct effect of SP on human dermal microvascular endothelial cell (HDMEC) intercellular adhesion molecule 1 (ICAM-1) expression and function.
Gene_expression (expression) of intercellular adhesion molecule 1 in endothelial cell associated with adhesions and substance p
15) Confidence 0.77 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9843720 Disease Relevance 0.19 Pain Relevance 0.36
ICAM-1 is both constitutively expressed and transcriptionally regulated on the surface of several cell types [29].
Gene_expression (expressed) of ICAM
16) Confidence 0.77 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1403781 Disease Relevance 0.47 Pain Relevance 0.20
Evidence presented in the current study also argues against a role for the local inflammatory milieu in regulating endothelial cell expressed ICAM-1.
Gene_expression (expressed) of ICAM in endothelial cell associated with inflammation
17) Confidence 0.77 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1403781 Disease Relevance 0.23 Pain Relevance 0.14
Conversely, expression of the adhesion molecule ICAM-1 was significantly increased in livers of brain-dead organ donors.
Gene_expression (expression) of ICAM-1 in livers
18) Confidence 0.76 Published 2006 Journal Neuroimmunomodulation Section Body Doc Link 16864968 Disease Relevance 0.14 Pain Relevance 0
Tissue biopsies were also analyzed for expression of intercellular adhesion molecule-1 (ICAM-1), which has a central function in inflammatory cell migration.
Spec (analyzed) Gene_expression (expression) of ICAM-1
19) Confidence 0.76 Published 2006 Journal Neuroimmunomodulation Section Body Doc Link 16864968 Disease Relevance 0.17 Pain Relevance 0
Whereas dexamethasone did not influence ICAM-1 expression in AM, it downregulated TNF alpha production at least in part at the transcriptional level.
Gene_expression (expression) of ICAM-1 associated with dexamethasone
20) Confidence 0.76 Published 1996 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8906220 Disease Relevance 0.52 Pain Relevance 0.35

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox