INT48408
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Culture for 24 h with rIFN-gamma resulted in a significant increase in ICAM-1 protein expression (82% of cells were strongly positive). | |||||||||||||||
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By contrast, dexamethasone did not influence rIFN-gamma-induced ICAM-1 expression. | |||||||||||||||
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ICAM-1 protein expression was studied on AMs by means of flow cytometry with an anti-CD54 monoclonal antibody; messenger ribonucleic acid (mRNA) levels were determined by reverse transcriptase-polymerase chain reaction (RT-PCR). | |||||||||||||||
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Modulation of ICAM-1 expression in human alveolar macrophages in vitro. | |||||||||||||||
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Modulation of intercellular adhesion molecule-1 (ICAM-1) expression may be a basic mechanism by which alveolar macrophages (AMs) regulate the inflammatory process in the lung in response to local stimuli. | |||||||||||||||
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Fusafungine significantly inhibited rIFN-gamma-induced ICAM-1-protein expression on AMs in a concentration-dependent fashion. | |||||||||||||||
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As a model for studying the anti-inflammatory activity of drugs on human AMs, we investigated the effects of fusafungine, an antibiotic for local use by aerosol with anti-inflammatory properties, and that of the glucocorticoid dexamethasone, on ICAM-1 expression induced in vitro by recombinant interferon-gamma (rIFN-gamma). | |||||||||||||||
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ICAM-1 was expressed before culture on 21% of bronchoalveolar lavage (BAL) cells, with low intensity. | |||||||||||||||
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Previously, it was demonstrated that immunoliposomes, bearing anti-intercellular adhesion molecule-1 (ICAM-1) antibodies (mAb F10.2), can specifically bind to different cell types expressing ICAM-1. | |||||||||||||||
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The results indicate that ICAM-1 targeted immunoliposomes may be used as carriers for the intracellular delivery of anti-inflammatory drugs to sites of inflammation characterised by an increased expression of ICAM-1. | |||||||||||||||
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HA binds to lymphocytes and endothelial cells expressing ICAM-1. | |||||||||||||||
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OBJECTIVES: To study the clinical effect of diagnostic overdistension plus hyaluronic acid (HA) instillations in interstitial cystitis and the association of the clinical response with the intensity of intercellular adhesion molecule (ICAM)-1 expression. | |||||||||||||||
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These results indicate that neuropeptides such as SP are capable of directly activating HDMEC to express increased levels of functional ICAM-1 and further support the role of the cutaneous neurological system in modulating inflammatory processes in the skin. | |||||||||||||||
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We examined the direct effect of SP on human dermal microvascular endothelial cell (HDMEC) intercellular adhesion molecule 1 (ICAM-1) expression and function. | |||||||||||||||
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We examined the direct effect of SP on human dermal microvascular endothelial cell (HDMEC) intercellular adhesion molecule 1 (ICAM-1) expression and function. | |||||||||||||||
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ICAM-1 is both constitutively expressed and transcriptionally regulated on the surface of several cell types [29]. | |||||||||||||||
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Evidence presented in the current study also argues against a role for the local inflammatory milieu in regulating endothelial cell expressed ICAM-1. | |||||||||||||||
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Conversely, expression of the adhesion molecule ICAM-1 was significantly increased in livers of brain-dead organ donors. | |||||||||||||||
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Tissue biopsies were also analyzed for expression of intercellular adhesion molecule-1 (ICAM-1), which has a central function in inflammatory cell migration. | |||||||||||||||
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Whereas dexamethasone did not influence ICAM-1 expression in AM, it downregulated TNF alpha production at least in part at the transcriptional level. | |||||||||||||||
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General Comments
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