INT48408

Context Info Confidence 0.78 First Reported 1994 Last Reported 2011 Negated 4 Speculated 20 Reported most in Abstract Documents 494 Total Number 514 Disease Relevance 340.08 Pain Relevance 88.60

extracellular space (ICAM1) cell adhesion (ICAM1) plasma membrane (ICAM1)

Anatomy Link Frequency endothelial cells 46 neutrophil 27 leukocytes 23 monocytes 15 Caco-2 13 ICAM1 (Homo sapiens) ICAM1 - K469E (1)

Pain Link Frequency Relevance Heat Inflammation 7284 100.00 cytokine 3797 100.00 chemokine 517 100.00 Inflammatory mediators 268 100.00 antagonist 237 100.00 dexamethasone 687 99.90 substance P 119 99.86 lidocaine 60 99.84 Migraine 43 99.84 ischemia 223 99.82

Disease Link Frequency Relevance Heat INFLAMMATION 8296 100.00 Adhesions 7741 100.00 Cancer 2128 100.00 Coronary Artery Disease 536 100.00 Necrosis 488 100.00 Chronic Fatigue Syndrome 31 100.00 Fowlpox 20 100.00 Polymyalgia Rheumatica 114 99.92 Nicotine Addiction 10239 99.84 Acquired Immune Deficiency Syndrome Or Hiv Infection 618 99.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Culture for 24 h with rIFN-gamma resulted in a significant increase in ICAM-1 protein expression (82% of cells were strongly positive).

Gene_expression (expression) of ICAM-1

1) Confidence 0.78 Published 1996 Journal Eur. Respir. J. Section Abstract Doc Link 8730005 Disease Relevance 0.28 Pain Relevance 0.25

By contrast, dexamethasone did not influence rIFN-gamma-induced ICAM-1 expression.

Gene_expression (expression) of ICAM-1 associated with dexamethasone

2) Confidence 0.78 Published 1996 Journal Eur. Respir. J. Section Abstract Doc Link 8730005 Disease Relevance 0.18 Pain Relevance 0.26

ICAM-1 protein expression was studied on AMs by means of flow cytometry with an anti-CD54 monoclonal antibody; messenger ribonucleic acid (mRNA) levels were determined by reverse transcriptase-polymerase chain reaction (RT-PCR).

Gene_expression (expression) of ICAM-1 in AMs

3) Confidence 0.78 Published 1996 Journal Eur. Respir. J. Section Abstract Doc Link 8730005 Disease Relevance 0.35 Pain Relevance 0.18

Modulation of ICAM-1 expression in human alveolar macrophages in vitro.

Gene_expression (expression) of ICAM-1 in alveolar macrophages

4) Confidence 0.78 Published 1996 Journal Eur. Respir. J. Section Title Doc Link 8730005 Disease Relevance 0.36 Pain Relevance 0.17

Modulation of intercellular adhesion molecule-1 (ICAM-1) expression may be a basic mechanism by which alveolar macrophages (AMs) regulate the inflammatory process in the lung in response to local stimuli.

Gene_expression (expression) of ICAM-1 in alveolar macrophages associated with inflammation and adhesions

5) Confidence 0.78 Published 1996 Journal Eur. Respir. J. Section Abstract Doc Link 8730005 Disease Relevance 0.36 Pain Relevance 0.16

Fusafungine significantly inhibited rIFN-gamma-induced ICAM-1-protein expression on AMs in a concentration-dependent fashion.

Gene_expression (expression) of ICAM-1-protein in AMs

6) Confidence 0.78 Published 1996 Journal Eur. Respir. J. Section Abstract Doc Link 8730005 Disease Relevance 0.26 Pain Relevance 0.26

As a model for studying the anti-inflammatory activity of drugs on human AMs, we investigated the effects of fusafungine, an antibiotic for local use by aerosol with anti-inflammatory properties, and that of the glucocorticoid dexamethasone, on ICAM-1 expression induced in vitro by recombinant interferon-gamma (rIFN-gamma).

Gene_expression (expression) of ICAM-1 in AMs associated with inflammation and dexamethasone

7) Confidence 0.78 Published 1996 Journal Eur. Respir. J. Section Abstract Doc Link 8730005 Disease Relevance 0.37 Pain Relevance 0.19

ICAM-1 was expressed before culture on 21% of bronchoalveolar lavage (BAL) cells, with low intensity.

Gene_expression (expressed) of ICAM-1

8) Confidence 0.78 Published 1996 Journal Eur. Respir. J. Section Abstract Doc Link 8730005 Disease Relevance 0.31 Pain Relevance 0.20

Previously, it was demonstrated that immunoliposomes, bearing anti-intercellular adhesion molecule-1 (ICAM-1) antibodies (mAb F10.2), can specifically bind to different cell types expressing ICAM-1.

Gene_expression (expressing) of ICAM-1 associated with adhesions

9) Confidence 0.78 Published 1999 Journal Biochim. Biophys. Acta Section Abstract Doc Link 10407086 Disease Relevance 0.17 Pain Relevance 0

The results indicate that ICAM-1 targeted immunoliposomes may be used as carriers for the intracellular delivery of anti-inflammatory drugs to sites of inflammation characterised by an increased expression of ICAM-1.

Gene_expression (expression) of ICAM-1 associated with inflammation and cinod

10) Confidence 0.78 Published 1999 Journal Biochim. Biophys. Acta Section Abstract Doc Link 10407086 Disease Relevance 0.34 Pain Relevance 0.15

HA binds to lymphocytes and endothelial cells expressing ICAM-1.

Gene_expression (expressing) of ICAM in endothelial cells

11) Confidence 0.78 Published 2002 Journal Urology Section Abstract Doc Link 12100920 Disease Relevance 0.25 Pain Relevance 0.16

OBJECTIVES: To study the clinical effect of diagnostic overdistension plus hyaluronic acid (HA) instillations in interstitial cystitis and the association of the clinical response with the intensity of intercellular adhesion molecule (ICAM)-1 expression.

Gene_expression (expression) of intercellular adhesion molecule associated with interstitial cystitis and adhesions

12) Confidence 0.78 Published 2002 Journal Urology Section Abstract Doc Link 12100920 Disease Relevance 0.27 Pain Relevance 0.17

These results indicate that neuropeptides such as SP are capable of directly activating HDMEC to express increased levels of functional ICAM-1 and further support the role of the cutaneous neurological system in modulating inflammatory processes in the skin.

Gene_expression (express) of ICAM-1 in skin associated with inflammation, neuropeptide and substance p

13) Confidence 0.77 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9843720 Disease Relevance 0.22 Pain Relevance 0.51

We examined the direct effect of SP on human dermal microvascular endothelial cell (HDMEC) intercellular adhesion molecule 1 (ICAM-1) expression and function.

Gene_expression (expression) of ICAM-1 in endothelial cell associated with adhesions and substance p

14) Confidence 0.77 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9843720 Disease Relevance 0.19 Pain Relevance 0.35

We examined the direct effect of SP on human dermal microvascular endothelial cell (HDMEC) intercellular adhesion molecule 1 (ICAM-1) expression and function.

Gene_expression (expression) of intercellular adhesion molecule 1 in endothelial cell associated with adhesions and substance p

15) Confidence 0.77 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9843720 Disease Relevance 0.19 Pain Relevance 0.36

ICAM-1 is both constitutively expressed and transcriptionally regulated on the surface of several cell types [29].

Gene_expression (expressed) of ICAM

16) Confidence 0.77 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1403781 Disease Relevance 0.47 Pain Relevance 0.20

Evidence presented in the current study also argues against a role for the local inflammatory milieu in regulating endothelial cell expressed ICAM-1.

Gene_expression (expressed) of ICAM in endothelial cell associated with inflammation

17) Confidence 0.77 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1403781 Disease Relevance 0.23 Pain Relevance 0.14

Conversely, expression of the adhesion molecule ICAM-1 was significantly increased in livers of brain-dead organ donors.

Gene_expression (expression) of ICAM-1 in livers

18) Confidence 0.76 Published 2006 Journal Neuroimmunomodulation Section Body Doc Link 16864968 Disease Relevance 0.14 Pain Relevance 0

Tissue biopsies were also analyzed for expression of intercellular adhesion molecule-1 (ICAM-1), which has a central function in inflammatory cell migration.

Spec (analyzed) Gene_expression (expression) of ICAM-1

19) Confidence 0.76 Published 2006 Journal Neuroimmunomodulation Section Body Doc Link 16864968 Disease Relevance 0.17 Pain Relevance 0

Whereas dexamethasone did not influence ICAM-1 expression in AM, it downregulated TNF alpha production at least in part at the transcriptional level.

Gene_expression (expression) of ICAM-1 associated with dexamethasone

20) Confidence 0.76 Published 1996 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8906220 Disease Relevance 0.52 Pain Relevance 0.35

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