INT4841

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Context Info
Confidence 0.80
First Reported 1984
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 26
Total Number 28
Disease Relevance 4.36
Pain Relevance 19.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npff) extracellular region (Npff)
Anatomy Link Frequency
spinal cord 10
spinal 3
nerve 2
dorsal root ganglia 2
medial 1
Npff (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 77 100.00 Very High Very High Very High
Morphine 38 99.82 Very High Very High Very High
substance P 90 99.80 Very High Very High Very High
Spinal cord 98 99.68 Very High Very High Very High
tetrodotoxin 8 99.42 Very High Very High Very High
Inflammation 17 99.32 Very High Very High Very High
narcan 8 99.28 Very High Very High Very High
tolerance 6 98.88 Very High Very High Very High
Analgesic 9 98.64 Very High Very High Very High
Opioid 13 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 9 99.56 Very High Very High Very High
INFLAMMATION 11 99.32 Very High Very High Very High
Pain 32 98.48 Very High Very High Very High
Hyperalgesia 9 98.32 Very High Very High Very High
Spinal Cord Injury 3 87.28 High High
Syndrome 1 82.88 Quite High
Opiate Addiction 1 81.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The NPFF-like material in superfusates recognized spinal NPFF receptors, suggesting that NPFF release in the spinal cord has a physiological role.
Localization (release) of NPFF in spinal associated with spinal cord
1) Confidence 0.80 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7891084 Disease Relevance 0.06 Pain Relevance 0.54
We also showed that NPFF release was a function of the extent of depolarization and was calcium dependent.
Localization (release) of NPFF
2) Confidence 0.80 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7891084 Disease Relevance 0.08 Pain Relevance 0.62
The opening of voltage-sensitive Na+ channels with veratridine (20 microM) induced calcium-dependent NPFF release, which was abolished by tetrodotoxin (1 microM), suggesting that NPFF release depends on nerve impulse activity.
Localization (release) of NPFF in nerve associated with tetrodotoxin
3) Confidence 0.80 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7891084 Disease Relevance 0.09 Pain Relevance 0.63
The released NPFF-IR was analyzed by an HPLC study and found to consist of NPFF and other minor immunoreactive peptides.
Localization (released) of NPFF-IR
4) Confidence 0.80 Published 1992 Journal Brain Res. Section Abstract Doc Link 1280519 Disease Relevance 0.08 Pain Relevance 0.87
Substance P (1-11) also produced a detectable release of NPFF-IR in vivo although the response was quite variable.
Localization (release) of NPFF-IR associated with substance p
5) Confidence 0.80 Published 1992 Journal Brain Res. Section Abstract Doc Link 1280519 Disease Relevance 0.08 Pain Relevance 0.81
Further studies with substance P-related peptides showed that the in vitro release of NPFF-IR could also be induced by substance P (1-7) but not by [pGlu5,Me-Phe8,Sar9]-substance P (5-11) or substance K.
Localization (release) of NPFF-IR associated with substance p
6) Confidence 0.80 Published 1992 Journal Brain Res. Section Abstract Doc Link 1280519 Disease Relevance 0.07 Pain Relevance 0.98
The pre- and postsynaptic localization of spinal NPFF receptors provide further support for heterogeneity in the pain modulation by NPFF and related agonists.
Localization (localization) of NPFF in spinal associated with pain and agonist
7) Confidence 0.78 Published 2000 Journal Synapse Section Abstract Doc Link 10579807 Disease Relevance 0.18 Pain Relevance 0.68
NPFF and NPFF receptor mRNAs are highly expressed and localized in the superficial layers of the dorsal cord, the two genes are also in dorsal root ganglia though at much lower level.
Localization (localized) of NPFF in dorsal root ganglia
8) Confidence 0.75 Published 2006 Journal Peptides Section Abstract Doc Link 16443306 Disease Relevance 0.55 Pain Relevance 0.68
NPFF and NPFF receptor mRNAs are highly expressed and localized in the superficial layers of the dorsal cord, the two genes are also in dorsal root ganglia though at much lower level.
Localization (localized) of NPFF in dorsal root ganglia
9) Confidence 0.75 Published 2006 Journal Peptides Section Abstract Doc Link 16443306 Disease Relevance 0.55 Pain Relevance 0.68
Release of neuropeptide FF (FLFQPQRF-NH2) from rat spinal cord.
Localization (Release) of neuropeptide FF in spinal cord associated with neuropeptide and spinal cord
10) Confidence 0.70 Published 1992 Journal Brain Res. Section Title Doc Link 1280519 Disease Relevance 0.08 Pain Relevance 0.74
The present experiments, using an in vitro superfusion of an isolated whole rat spinal cord, demonstrated that high concentrations of KCl or substance P caused a release of NPFF immunoreactive material (IR) from the spinal cord into the perfusion medium in a calcium-dependent manner.
Localization (release) of NPFF in spinal cord associated with substance p and spinal cord
11) Confidence 0.70 Published 1992 Journal Brain Res. Section Abstract Doc Link 1280519 Disease Relevance 0.09 Pain Relevance 0.73
Neuropeptide FF (NPFF) is highly localized in the dorsal spinal cords where there are also specific NPFF binding sites.
Localization (localized) of NPFF in spinal cords associated with neuropeptide
12) Confidence 0.70 Published 1992 Journal Brain Res. Section Abstract Doc Link 1280519 Disease Relevance 0.09 Pain Relevance 0.56
These results suggest that the specific substance P receptor (SP-N), which is recognized by both substance P (1-11) and substance P (1-7) rather than the tachykinin receptor, is involved in NPFF secretion from the spinal cord.
Localization (secretion) of NPFF in spinal cord associated with spinal cord and substance p
13) Confidence 0.70 Published 1992 Journal Brain Res. Section Abstract Doc Link 1280519 Disease Relevance 0.06 Pain Relevance 0.92
Neuropeptide FF (NPFF) is highly localized in the dorsal spinal cords where there are also specific NPFF binding sites.
Localization (localized) of Neuropeptide FF in spinal cords associated with neuropeptide
14) Confidence 0.70 Published 1992 Journal Brain Res. Section Abstract Doc Link 1280519 Disease Relevance 0.09 Pain Relevance 0.57
In the present study, the stable analog 1DMe ([D.Tyr(1), (NMe)Phe(3)]neuropeptide FF) was used in quantitative autoradiographic experiments in combination with surgical and chemical lesions to precisely localize NPFF receptors in the rat spinal cord.
Localization (localize) of NPFF in spinal cord associated with neuropeptide and spinal cord
15) Confidence 0.68 Published 2000 Journal Synapse Section Abstract Doc Link 10579807 Disease Relevance 0.07 Pain Relevance 0.51
In contrast, unilateral microinjections of kainic acid into the dorsal horn dramatically reduced [(125)I]1DMe-specific binding in the superficial layers, revealing localization of a population of NPFF receptors on the spinal intrinsic neurons.
Localization (localization) of NPFF in dorsal horn associated with dorsal horn
16) Confidence 0.68 Published 2000 Journal Synapse Section Abstract Doc Link 10579807 Disease Relevance 0.09 Pain Relevance 0.71
The distribution of NPFF receptor 2 gene expression is very similar to that of the NPFF peptide with a striking localization in the superficial layer of spinal cord.
Localization (localization) of NPFF in spinal cord associated with spinal cord
17) Confidence 0.65 Published 2003 Journal Neuroscience Section Abstract Doc Link 12676148 Disease Relevance 0.66 Pain Relevance 1.11
Thus, immunoneutralization of NPFF appears to selectively restore morphine sensitivity in opiate-tolerant animals.
Localization (immunoneutralization) of NPFF associated with opiate and morphine
18) Confidence 0.65 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1787914 Disease Relevance 0.16 Pain Relevance 1.42
Regulation and localization of spinal NPFF systems, taken together with the analgesic bioactivity of intrathecally administered NPFF, strongly suggest involvement of spinal NPFF system in pain processing.
Localization (localization) of NPFF in spinal associated with pain and analgesic
19) Confidence 0.62 Published 2006 Journal Peptides Section Abstract Doc Link 16443306 Disease Relevance 0.56 Pain Relevance 0.64
Within the NTS, most double- and triple-labelled NPFF neurons were localized at the level of the area postrema or just rostral to it and within the medial and dorsomedial subdivisions of the nucleus.
Localization (localized) of NPFF in medial
20) Confidence 0.62 Published 2001 Journal J. Chem. Neuroanat. Section Abstract Doc Link 11312058 Disease Relevance 0 Pain Relevance 0.38

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