INT48411

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Context Info
Confidence 0.77
First Reported 1994
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 35
Total Number 35
Disease Relevance 27.05
Pain Relevance 4.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd44) Golgi apparatus (Cd44) plasma membrane (Cd44)
nucleus (Cd44) protein complex (Cd44) cytoplasm (Cd44)
Anatomy Link Frequency
apoptotic cells 2
bone marrow 1
spleens 1
effector T cells 1
CTLs 1
Cd44 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 12 99.78 Very High Very High Very High
b2 receptor 17 99.56 Very High Very High Very High
Central nervous system 99 99.32 Very High Very High Very High
Arthritis 8 98.84 Very High Very High Very High
peptic ulcer disease 15 98.52 Very High Very High Very High
aspirin 15 97.12 Very High Very High Very High
Inflammation 255 96.96 Very High Very High Very High
ischemia 45 95.68 Very High Very High Very High
Spinal cord 22 95.68 Very High Very High Very High
chemokine 68 93.84 High High
Disease Link Frequency Relevance Heat
Adhesions 82 100.00 Very High Very High Very High
Stomach Cancer 10 99.84 Very High Very High Very High
Apoptosis 232 99.82 Very High Very High Very High
Carcinoma 51 99.80 Very High Very High Very High
Adenocarcinoma 53 99.52 Very High Very High Very High
Breast Cancer 15 99.48 Very High Very High Very High
Central Nervous System Disease 30 99.32 Very High Very High Very High
Arthritis 9 98.84 Very High Very High Very High
Ulcers 5 98.52 Very High Very High Very High
Cancer 1102 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CD44, an integral membrane glycoprotein expressed by many cell types, serves as the principal transmembrane hyaluronate receptor and may be a determinant of metastatic and invasive behavior in carcinomas.
Gene_expression (expressed) of CD44 associated with carcinoma
1) Confidence 0.77 Published 1994 Journal Hum. Pathol. Section Abstract Doc Link 7523275 Disease Relevance 0.65 Pain Relevance 0.16
The expression of CD44 in 23 gastric adenocarcinoma and 12 peptic ulcer disease (PUD) resection specimens and gastric carcinoma cell lines HS746t and KATO III was examined by immunohistochemistry using the murine monoclonal antibody A3D8 on formalin-fixed, paraffin-embedded tissue or cells.
Gene_expression (expression) of CD44 in KATO III associated with adenocarcinoma, peptic ulcer disease, disease and stomach cancer
2) Confidence 0.77 Published 1994 Journal Hum. Pathol. Section Abstract Doc Link 7523275 Disease Relevance 0.90 Pain Relevance 0.26
A key consequence of CD44 overexpression in gastric carcinomas may be development of the invasive phenotype and strong expression may indicate a poorer prognosis.
Gene_expression (overexpression) of CD44 associated with stomach cancer
3) Confidence 0.77 Published 1994 Journal Hum. Pathol. Section Abstract Doc Link 7523275 Disease Relevance 1.58 Pain Relevance 0.17
Five of the 11 patients whose carcinomas strongly expressed CD44 died within the study period with a mean length of survival of 11.0 months.
Gene_expression (expressed) of CD44 associated with carcinoma
4) Confidence 0.77 Published 1994 Journal Hum. Pathol. Section Abstract Doc Link 7523275 Disease Relevance 1.76 Pain Relevance 0.18
Expression of the cell adhesion molecule CD44 in gastric adenocarcinomas.
Gene_expression (Expression) of CD44 associated with adenocarcinoma and adhesions
5) Confidence 0.77 Published 1994 Journal Hum. Pathol. Section Title Doc Link 7523275 Disease Relevance 1.40 Pain Relevance 0.25
Flow cytometric analysis revealed an elevation in the T-cell population that expressed CD44, a marker of murine memory T-cells, in spleens from pristane-injected mice.
Gene_expression (expressed) of CD44 in spleens
6) Confidence 0.77 Published 1994 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 7514159 Disease Relevance 0.71 Pain Relevance 0.15
The phenotype of CD4(+)CD25(+) Treg cells, including the expressions of CD44, CD45RB, CD62L, CD69, GITR and CTLA-4, did not show detectable changes in ASA-treated mice.
Gene_expression (expressions) of CD44 associated with aspirin
7) Confidence 0.57 Published 2009 Journal Transpl. Immunol. Section Abstract Doc Link 19146957 Disease Relevance 0.21 Pain Relevance 0.69
However, neither the level of apoptosis nor the expression of cell adhesion molecules such as LFA-1 and CD44 were altered in CNS-infiltrating T cells (Fig. 6A and data not shown).
Gene_expression (expression) of CD44 in T cells associated with central nervous system, apoptosis and adhesions
8) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 1.15 Pain Relevance 0.14
Consistent with in vitro observations (Fig. 1D & G), Thy1.2+ CTLs labeled with VT680 remained fluorescent, did not transfer fluorescence to adjacent cells, and showed the same level of CD25 and CD44 expression when compared to unlabeled CTLs, further substantiating the conclusion that VT680 does not alter cell function.
Gene_expression (expression) of CD44 in CTLs
9) Confidence 0.51 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2034600 Disease Relevance 0.65 Pain Relevance 0.04
In parallel, to test whether VT680 activates cells in vivo, we measured levels of CD25 and CD44 expression on Thy1.2 (VT680+) and Thy1.1 (unstained) cells (Fig. 1J).
Gene_expression (expression) of CD44
10) Confidence 0.51 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2034600 Disease Relevance 0.17 Pain Relevance 0.04
The isolated bone marrow cells express CD34 (9.67%), CD44 (53.90%), Sca-1 (27.25%) and CD45 (60.04%), therefore confirming a phenotype of mesenchymal stem cells.
Gene_expression (express) of CD44 in bone marrow
11) Confidence 0.51 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2974740 Disease Relevance 0.46 Pain Relevance 0.04
According to our double labeling procedure, Cd44, Tnfsf9 and Cd83 are expressed mainly by microglial cells, Lcn2 by endothelial cells and Saa3 transcript by microglia and few astrocytes.
Gene_expression (expressed) of Cd44 in astrocytes
12) Confidence 0.48 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.15 Pain Relevance 0
Immunohistochemistry was combined with the in situ hybridization histochemistry protocol to determine the types of cells that express Cd44, Cd83, Cp, Lcn2, Saa3, Stat1 and Tnfsf9 transcripts.
Gene_expression (express) of Cd44
13) Confidence 0.48 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0 Pain Relevance 0
Despite the relatively high transcript levels of PDGFRa, Tie2, c-kit, CD59, CD63, CD44 and CD24 in RoSH and E-RoSH cells, they were not immunoreactive against PDGFRa, Tie2, c-kit, CD59, CD63, CD44 and CD24 (data not shown).
Gene_expression (levels) of CD44
14) Confidence 0.45 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762397 Disease Relevance 0.25 Pain Relevance 0
Also, a recent study demonstrated that rapid CD44 upregulation on renal capillary endothelial cells mediates neutrophil recruitment to the postischemic tissue in a renal ischemia-perfusion mouse model.
Gene_expression (upregulation) of CD44 in capillary associated with ischemia
15) Confidence 0.42 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 1.03 Pain Relevance 0.11
1-antichimotrypsin), Cd44, and Ch25h expression levels were also verified, because of the novelty of the gene array results and their possible involvement in the physiopathology of Alzheimer's disease [25]–[27].
Gene_expression (expression) of Cd44 associated with disease
16) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.53 Pain Relevance 0.20
In contrast, splenic T cells showed significantly increased apoptosis, reduced surface levels of LFA-1, CD44 and VLA-4 and impaired lymphocyte migration to the inflamed CNS [19].
Gene_expression (levels) of CD44 in lymphocyte associated with central nervous system and apoptosis
17) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 1.55 Pain Relevance 0.38
While the percentage of apoptotic cells was again unaltered, surface expression levels of LFA-1 and CD44 were reduced on Th cells from CpdA treated mice in a dose-dependent manner (Fig. 6B).
Gene_expression (levels) of CD44 in apoptotic cells associated with apoptosis
18) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 0.90 Pain Relevance 0.17
Our mechanistic studies revealed that CpdA acts by down regulating expression of the cell adhesion molecules LFA-1 and CD44 on peripheral Th cells and by repressing IL-17 production by antigen-specific effector T cells.
Gene_expression (expression) of CD44 in effector T cells associated with adhesions
19) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 0.65 Pain Relevance 0.07
While the percentage of apoptotic cells was again unaltered, surface expression levels of LFA-1 and CD44 were reduced on Th cells from CpdA treated mice in a dose-dependent manner (Fig. 6B).
Gene_expression (expression) of CD44 in apoptotic cells associated with apoptosis
20) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 0.95 Pain Relevance 0.17

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