INT4843

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1992
Last Reported 2010
Negated 1
Speculated 4
Reported most in Abstract
Documents 50
Total Number 56
Disease Relevance 12.92
Pain Relevance 36.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npff) extracellular region (Npff)
Anatomy Link Frequency
spinal cord 11
brain 3
brainstem 3
hypothalamus 3
neurons 3
Npff (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 138 100.00 Very High Very High Very High
Morphine 81 100.00 Very High Very High Very High
analgesia 52 100.00 Very High Very High Very High
Central nervous system 18 100.00 Very High Very High Very High
Hyperalgesia 9 99.96 Very High Very High Very High
Spinal cord 85 99.86 Very High Very High Very High
substance P 10 99.74 Very High Very High Very High
Inflammation 72 99.64 Very High Very High Very High
medulla 29 99.52 Very High Very High Very High
ASIC 11 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 9 99.96 Very High Very High Very High
INFLAMMATION 52 99.64 Very High Very High Very High
Nociception 32 99.56 Very High Very High Very High
Pain 63 98.88 Very High Very High Very High
Neuropathic Pain 20 98.08 Very High Very High Very High
Tics 4 97.92 Very High Very High Very High
Cv Unclassified Under Development 10 94.56 High High
Inflammatory Pain 2 94.24 High High
Urological Neuroanatomy 2 79.20 Quite High
Hyperphagia 1 73.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NPFF and NPFF receptor mRNAs are highly expressed and localized in the superficial layers of the dorsal cord, the two genes are also in dorsal root ganglia though at much lower level.
Gene_expression (expressed) of NPFF in dorsal root ganglia
1) Confidence 0.78 Published 2006 Journal Peptides Section Abstract Doc Link 16443306 Disease Relevance 0.55 Pain Relevance 0.67
NPFF and NPFF receptor mRNAs are highly expressed and localized in the superficial layers of the dorsal cord, the two genes are also in dorsal root ganglia though at much lower level.
Gene_expression (expressed) of NPFF in dorsal root ganglia
2) Confidence 0.78 Published 2006 Journal Peptides Section Abstract Doc Link 16443306 Disease Relevance 0.55 Pain Relevance 0.67
In the rat spinal cord, gene expression of NPFF but not that of NPVF was up-regulated by persistent pain induced by carrageenan inflammation.
Gene_expression (expression) of NPFF in spinal cord associated with pain, inflammation, lasting pain and spinal cord
3) Confidence 0.78 Published 2003 Journal Neuroscience Section Abstract Doc Link 12676148 Disease Relevance 0.65 Pain Relevance 0.84
In rats with carrageenan inflammation of the hind paw, expression of both NPFF and NPFF receptor 2 genes was up-regulated in the spinal cord, while expression of NPVF and NPFF receptor 1 genes was not affected.
Gene_expression (expression) of NPFF in spinal cord associated with inflammation and spinal cord
4) Confidence 0.78 Published 2003 Journal Neuroscience Section Abstract Doc Link 12676148 Disease Relevance 0.65 Pain Relevance 1.19
In rats with carrageenan inflammation of the hind paw, expression of both NPFF and NPFF receptor 2 genes was up-regulated in the spinal cord, while expression of NPVF and NPFF receptor 1 genes was not affected.
Gene_expression (expression) of NPFF in spinal cord associated with inflammation and spinal cord
5) Confidence 0.78 Published 2003 Journal Neuroscience Section Abstract Doc Link 12676148 Disease Relevance 0.65 Pain Relevance 1.17
In rats with carrageenan inflammation of the hind paw, expression of both NPFF and NPFF receptor 2 genes was up-regulated in the spinal cord, while expression of NPVF and NPFF receptor 1 genes was not affected.
Gene_expression (expression) of NPFF in spinal cord associated with inflammation and spinal cord
6) Confidence 0.78 Published 2003 Journal Neuroscience Section Abstract Doc Link 12676148 Disease Relevance 0.66 Pain Relevance 1.17
The distribution of NPFF gene expression is very similar to that of NPFF immunoreactive peptide but is distinct from NPVF gene expression.
Gene_expression (expression) of NPFF gene
7) Confidence 0.78 Published 2003 Journal Neuroscience Section Abstract Doc Link 12676148 Disease Relevance 0.56 Pain Relevance 0.76
Significantly greater numbers of activated neurons expressing the NPFF gene (double labeled) were observed in the NTS at the level of the area postrema in animals receiving i.c.v.
Gene_expression (expressing) of NPFF gene in area postrema
8) Confidence 0.78 Published 2002 Journal J. Comp. Neurol. Section Abstract Doc Link 11984823 Disease Relevance 0.08 Pain Relevance 0.11
NPFF gene expression in the NTS showed a similar dose-dependent increase following i.c.v. administration of either 8 or 10 microg of NPFF.
Gene_expression (expression) of NPFF gene
9) Confidence 0.78 Published 2002 Journal J. Comp. Neurol. Section Abstract Doc Link 11984823 Disease Relevance 0.14 Pain Relevance 0.14
Central administration of neuropeptide FF (NPFF) causes increased neuronal activation and up-regulation of NPFF gene expression in the rat brainstem.
Gene_expression (expression) of NPFF gene in brainstem associated with medulla and neuropeptide
10) Confidence 0.78 Published 2002 Journal J. Comp. Neurol. Section Title Doc Link 11984823 Disease Relevance 0.15 Pain Relevance 0.33
In fluorescent immunohistochemical staining, our results revealed that NPFF(1) and NPFF(2) receptors could be expressed at the TH (tyrosine hydroxylase)- or GAD67 (glutamic acid decarboxylase-67)-positive neurons in VTA, whereas some of them were present in the negative neurons.
Gene_expression (expressed) of NPFF in neurons
11) Confidence 0.77 Published 2010 Journal Peptides Section Abstract Doc Link 20381562 Disease Relevance 0 Pain Relevance 0.81
Our results showed that both NPFF receptors were abundantly expressed in VTA but with less content in NAc.
Gene_expression (expressed) of NPFF
12) Confidence 0.77 Published 2010 Journal Peptides Section Abstract Doc Link 20381562 Disease Relevance 0 Pain Relevance 0.83
The genes encoding NPFF precursor proteins and NPFF receptors 1 and 2 are expressed in all vertebrate species examined to date and are highly conserved.
Spec (examined) Gene_expression (expressed) of NPFF
13) Confidence 0.76 Published 2008 Journal Neuropeptides Section Abstract Doc Link 17854890 Disease Relevance 0.07 Pain Relevance 0.74
The genes for NPFF as well as NPFF-R2, preferred receptor for NPFF, are highly unevenly expressed in the rat CNS with the highest levels localized to the superficial layers of the dorsal spinal cord.
Gene_expression (expressed) of NPFF in spinal cord associated with spinal cord
14) Confidence 0.76 Published 2008 Journal Neuropeptides Section Abstract Doc Link 17854890 Disease Relevance 0.37 Pain Relevance 1.28
The genes encoding NPFF precursor proteins and NPFF receptors 1 and 2 are expressed in all vertebrate species examined to date and are highly conserved.
Spec (examined) Gene_expression (expressed) of NPFF
15) Confidence 0.76 Published 2008 Journal Neuropeptides Section Abstract Doc Link 17854890 Disease Relevance 0.07 Pain Relevance 0.74
Our results confirm the evolutionary conservation of NPFF, NPAF, and NPSF neuropeptide expression in mammalian brain.
Gene_expression (expression) of NPFF in brain associated with neuropeptide
16) Confidence 0.75 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10220558 Disease Relevance 0.43 Pain Relevance 0.92
We demonstrate that NPFF precursor mRNA expression by Northern analysis and map sites of expression by in situ hybridization.
Gene_expression (expression) of NPFF
17) Confidence 0.75 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10220558 Disease Relevance 0.30 Pain Relevance 0.69
We measured the reduction by nociceptin of the [Ca(2+)](i) transient triggered by depolarization in acutely dissociated neurones of the rat dorsal raphe and periventricular hypothalamic nuclei that express NPFF(2) and NPFF(1) receptors, respectively, in the absence and presence of 10 nM of NPA-NPFF or NPVF, two peptides selective for NPFF(2) and NPFF(1) receptors, respectively.
Gene_expression (express) of NPFF in dorsal associated with orphanin and raphe
18) Confidence 0.75 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12932818 Disease Relevance 0 Pain Relevance 0.42
Neuropeptide FF (NPFF) is a mammalian peptide that is found in high concentrations in the central nervous system (CNS) and has also been detected in plasma.
Gene_expression (detected) of NPFF in plasma associated with neuropeptide and central nervous system
19) Confidence 0.68 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11682148 Disease Relevance 0 Pain Relevance 0.43
NPFF mRNA expression is upregulated in the dorsal horn of the spinal cord after carrageenan-induced inflammation in the hind paw of the rat, but not in the neuropathic pain model induced by ligation of the spinal roots.
Gene_expression (expression) of NPFF in dorsal horn associated with inflammation, neuropathic pain, dorsal horn and spinal cord
20) Confidence 0.68 Published 1999 Journal Brain Res. Section Abstract Doc Link 10612711 Disease Relevance 0.58 Pain Relevance 1.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox