INT48438

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Context Info
Confidence 0.09
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.96
Pain Relevance 2.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Defb22)
Anatomy Link Frequency
cerebrospinal fluid 4
brain 1
Defb22 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 5 99.98 Very High Very High Very High
excitatory amino acid 4 99.84 Very High Very High Very High
Inflammation 2 99.76 Very High Very High Very High
Morphine 7 99.24 Very High Very High Very High
Kinase C 4 98.48 Very High Very High Very High
Thermal hyperalgesia 1 98.44 Very High Very High Very High
Serotonin 1 98.04 Very High Very High Very High
intrathecal 1 97.00 Very High Very High Very High
IPN 2 96.64 Very High Very High Very High
Pain 3 96.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 4 100.00 Very High Very High Very High
Hypertension 7 99.02 Very High Very High Very High
Hyperalgesia 2 98.44 Very High Very High Very High
Stroke 2 98.36 Very High Very High Very High
Bordatella Infection 2 97.60 Very High Very High Very High
Inflammatory Pain 2 96.64 Very High Very High Very High
Pain 3 96.60 Very High Very High Very High
Pathologic Constriction 1 92.56 High High
Syndrome 1 90.52 High High
Neuropathic Pain 1 90.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have analyzed: BBB integrity with the Trypan Blue diffusion method (TB, Reynolds), protein concentration (PC) in Cerebrospinal Fluid (CSF) and plasma (Bradford method), electroencephalographic activity (EEG), cerebral edema expressed as brain water content (gravidimetric test), and behavior: Animex, righting reflex, pain reflex and Rotarod.
Gene_expression (expressed) of Cerebrospinal Fluid in brain associated with pain and pressure and volume under development
1) Confidence 0.09 Published 2001 Journal Medicina (B Aires) Section Abstract Doc Link 12058587 Disease Relevance 0.76 Pain Relevance 0.18
Superfusion of the ventral medullary surface of anesthetized (urethane, 1.2 g/kg, ip) male adult Wistar rats (250-350 g) with high K+ (40 mM) surrogate cerebrospinal fluid (CSF) produced an average increase of 45% over the spontaneous efflux of exogeneously applied glycine (N = 5, P < 0.01).
Gene_expression (produced) of cerebrospinal fluid in CSF
2) Confidence 0.07 Published 1996 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 8736120 Disease Relevance 0 Pain Relevance 0.06
Substance P expression in the distal cerebrospinal fluid-contacting neurons and spinal trigeminal nucleus in formalin-induced the orofacial inflammatory pain in rats.
Gene_expression (expression) of cerebrospinal fluid in cerebrospinal fluid associated with ipn and substance p
3) Confidence 0.03 Published 2009 Journal Brain Res. Bull. Section Title Doc Link 19103267 Disease Relevance 0.40 Pain Relevance 0.82
In our previous studies, we found that intrathecal (i.t.) injection of pertussis toxin (PTX) produces thermal hyperalgesia, which is poorly responsive to morphine and is accompanied by an increase in cerebrospinal fluid (CSF) levels of excitatory amino acids (EAAs) and protein kinase C (PKC) activation.
Gene_expression (levels) of cerebrospinal fluid in CSF associated with kinase c, bordatella infection, thermal hyperalgesia, excitatory amino acid, morphine and intrathecal
4) Confidence 0.02 Published 2006 Journal Life Sci. Section Abstract Doc Link 16271370 Disease Relevance 0.45 Pain Relevance 1.15
The purpose of the present study was to evaluate stroke-prone spontaneously hypertensive rats (SHRSP) neurochemically by determining the cerebrospinal fluid (CSF) levels of acetylcholine (ACh), norepinephrine (NE) and serotonin (5-HT) as an index of central neuronal activity.
Gene_expression (levels) of cerebrospinal fluid in cerebrospinal fluid associated with stroke, hypertension and serotonin
5) Confidence 0.02 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7514774 Disease Relevance 0.35 Pain Relevance 0.13

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