INT48449

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.61
First Reported 1994
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 11
Total Number 14
Disease Relevance 4.24
Pain Relevance 3.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Chat) transferase activity, transferring acyl groups (Chat)
Anatomy Link Frequency
neuronal 2
amacrine cell 2
neurons 1
lamina 1
dorsal horn 1
Chat (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 10 100.00 Very High Very High Very High
Spinal cord 108 99.68 Very High Very High Very High
spinal dorsal horn 24 99.68 Very High Very High Very High
dorsal root ganglion 93 99.24 Very High Very High Very High
analgesia 27 98.22 Very High Very High Very High
Nicotine 87 97.86 Very High Very High Very High
unmyelinated 16 97.08 Very High Very High Very High
Dorsal horn 29 91.88 High High
gABA 33 91.20 High High
Pain 44 90.56 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 48 99.68 Very High Very High Very High
Targeted Disruption 135 99.66 Very High Very High Very High
Death 27 99.34 Very High Very High Very High
Ganglion Cysts 263 99.24 Very High Very High Very High
Disease 123 95.52 Very High Very High Very High
Pain 27 90.56 High High
Low Back Pain 21 83.52 Quite High
Vibrio Infection 2 80.00 Quite High
Nociception 58 77.92 Quite High
Injury 3 73.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alterations in acetylcholinesterase and choline acetyltransferase activities and neuropeptide levels in the ventral spinal cord of the Wobbler mouse during inherited motoneuron disease.
Regulation (Alterations) of choline acetyltransferase in ventral associated with neuropeptide, disease and spinal cord
1) Confidence 0.61 Published 1994 Journal Brain Res. Section Title Doc Link 7515324 Disease Relevance 0.42 Pain Relevance 0.37
Alternatively, the nicotine-induced analgesia observed in the present study may be explained by supersensitivity of nAChR due to down-regulation of cholinergic activities by ChAT AS-ODN.
Regulation (regulation) of ChAT AS-ODN associated with nicotine and analgesia
2) Confidence 0.34 Published 2007 Journal Mol Pain Section Body Doc Link PMC2234393 Disease Relevance 0.40 Pain Relevance 1.21
Consistently, in transgenic mice, where the ChAT promoter drives the GFP expression [ChAT (BAC)-eGFP], we found that there were abundant GFP-positive cells in the VNOs (Fig. 2G).
Regulation (drives) of ChAT associated with targeted disruption
3) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912856 Disease Relevance 0.10 Pain Relevance 0.06
Consistently, in transgenic mice, where the ChAT promoter drives the GFP expression [ChAT (BAC)-eGFP], we found that there were abundant GFP-positive cells in the VNOs (Fig. 2G).
Regulation (drives) of ChAT associated with targeted disruption
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912856 Disease Relevance 0.10 Pain Relevance 0.05
Intense ChAT immunoreactivity was observed in the lamina IX regions of the ventral horn and the lamina X regions encircling the central canal, and modest activity was seen in fiber-like structures in the lamina I–III regions of the dorsal horn (Fig. 1A).
Regulation (immunoreactivity) of ChAT in lamina associated with dorsal horn
5) Confidence 0.24 Published 2007 Journal Mol Pain Section Body Doc Link PMC2234393 Disease Relevance 0.59 Pain Relevance 0.65
These data suggest that ChAT immunoreactivities in the spinal dorsal horn are derived from the fibers of myelinated and unmyelinated types of primary afferent cholinergic neurons.
Regulation (immunoreactivities) of ChAT in dorsal horn associated with spinal dorsal horn and unmyelinated
6) Confidence 0.24 Published 2007 Journal Mol Pain Section Body Doc Link PMC2234393 Disease Relevance 0.58 Pain Relevance 0.65
Whether ChAT and VAChT expression is affected remains to be analysed.


Spec (Whether) Regulation (affected) of ChAT
7) Confidence 0.23 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.18 Pain Relevance 0.05
In order to test whether there was a correlation between alpha-synuclein pathology and cell death in IML neurons, we analyzed the ChAT+ neuronal population in the IML.
Spec (analyzed) Regulation (population) of ChAT in neuronal associated with death and spinal cord
8) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808242 Disease Relevance 0.91 Pain Relevance 0.49
Finally, we analyzed the effect of rotenone treatment on the ChAT+ neuronal population in the DMV.
Spec (analyzed) Regulation (effect) of ChAT in neuronal
9) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808242 Disease Relevance 0.13 Pain Relevance 0.07
In parallel with changes in hippocampal ChAT levels, the number of ChAT-immunoreactive neurons in 5XFAD and BACE1+/?
Regulation (changes) of ChAT in neurons
10) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.06 Pain Relevance 0.04
ChAT immunoreactivity was localized to amacrine and displaced amacrine cell bodies distributed in the INL and GCL, and their processes that narrowly stratified in laminae 2 and 4 of the IPL (Figure 8).
Regulation (immunoreactivity) of ChAT in amacrine cell
11) Confidence 0.19 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519030 Disease Relevance 0 Pain Relevance 0
To address this issue we performed a triple fluorescence analysis combining EGFP fluorescence with DARPP-32 and ChAT immunofluorescence in drd1a-EGFP/drd2-EGFP double transgenic mice (Fig. 5A, B).
Regulation (immunofluorescence) of ChAT associated with targeted disruption
12) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0.30 Pain Relevance 0
Another possibility is that decreases in the abundance of ChAT/CRABP-positive cells in the IPL resulted from the down-regulation of ChAT and CRABP.
Regulation (regulation) of ChAT
13) Confidence 0.08 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2267169 Disease Relevance 0.17 Pain Relevance 0
A normal distribution of glial fibrillary acid protein (GFAP; labels Muller cells), calbindin- (CALB; labels horizontal cells) and choline acetyltransferase (ChAT; labels cholinergic amacrine cells) immunoreactivity was observed in both control and UF008/SAP injected eyes.
Regulation (immunoreactivity) of choline acetyltransferase in amacrine cells
14) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2519834 Disease Relevance 0.29 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox