INT48456

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Context Info
Confidence 0.56
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.63
Pain Relevance 3.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (WAS) protein complex assembly (WAS) cytoplasm (WAS)
Anatomy Link Frequency
fat 1
striatum 1
urine 1
WAS (Homo sapiens)
Pain Link Frequency Relevance Heat
Cannabinoid 134 100.00 Very High Very High Very High
Delta-9-tetrahydrocannabinol 27 100.00 Very High Very High Very High
Pain 24 99.56 Very High Very High Very High
Dynorphin 4 99.52 Very High Very High Very High
Enkephalin 6 98.56 Very High Very High Very High
analgesia 6 97.28 Very High Very High Very High
Opioid 6 96.64 Very High Very High Very High
Neuropeptide 2 96.64 Very High Very High Very High
opiate 7 96.36 Very High Very High Very High
substance P 3 96.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sprains And Strains 3 100.00 Very High Very High Very High
Pain 30 99.56 Very High Very High Very High
Stress 7 96.80 Very High Very High Very High
Sleep Disorders 14 93.20 High High
Nicotine Addiction 40 78.76 Quite High
Schizophrenia 11 78.32 Quite High
Anxiety Disorder 6 73.08 Quite High
Depression 18 72.60 Quite High
Cannabis Dependence 5 67.44 Quite High
Ocular Hypertension 2 63.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pharmacokinetics of THC with its prolonged storage in fat and its slow release result in variable and delayed pharmacological response, which precludes precise dosing to achieve timely therapeutic effects.
Localization (release) of THC in fat
1) Confidence 0.56 Published 2002 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 12188105 Disease Relevance 0.11 Pain Relevance 0.32
THC is excreted into human breast milk in moderate amounts [19].
Localization (excreted) of THC
2) Confidence 0.48 Published 2009 Journal Journal of Toxicology Section Body Doc Link PMC2809366 Disease Relevance 0.69 Pain Relevance 0.54
Nevertheless, there was recognition that different medical conditions may require different approaches, such as different active agents (e.g., THC versus other cannabinoids), strains or methods (e.g., slow release pill versus fast-acting spray).
Localization (release) of THC associated with cannabinoid and sprains and strains
3) Confidence 0.47 Published 2005 Journal Harm Reduct J Section Body Doc Link PMC1262744 Disease Relevance 0.18 Pain Relevance 0.26
Delta(9)-THC, an active constituent in marijuana, releases endogenous dynorphin A and leucine enkephalin in the production of analgesia.
Localization (releases) of THC associated with dynorphin, enkephalin and analgesia
4) Confidence 0.45 Published 1999 Journal Brain Res. Section Abstract Doc Link 10612710 Disease Relevance 0.10 Pain Relevance 1.17
THC can accumulate in human breast milk to high concentrations [19], and infants exposed to marijuana through their mother's milk will excrete THC in their urine during 2 to 3 weeks [21].
Localization (excrete) of THC in urine
5) Confidence 0.42 Published 2009 Journal Journal of Toxicology Section Body Doc Link PMC2809366 Disease Relevance 0.17 Pain Relevance 0.19
We have recently localized delta-9-tetrahydrocannabinol (THC) receptor in the projecting neurons of the striatum which are known to express the neuropeptides substance P and enkephalin.
Localization (localized) of THC in striatum associated with neuropeptide, delta-9-tetrahydrocannabinol, enkephalin and substance p
6) Confidence 0.20 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7515821 Disease Relevance 0 Pain Relevance 0.62
How does repeated use of THC influence these states?
Localization (use) of THC associated with delta-9-tetrahydrocannabinol
7) Confidence 0.13 Published 2005 Journal Harm Reduct J Section Body Doc Link PMC1261530 Disease Relevance 0.38 Pain Relevance 0.85

General Comments

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