INT48462

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Context Info
Confidence 0.70
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 1.00
Pain Relevance 3.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
medial 3
brain 2
dorsal horn 2
hippocampus 1
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 12 99.98 Very High Very High Very High
substance P 8 99.96 Very High Very High Very High
qutenza 5 99.88 Very High Very High Very High
Hippocampus 14 99.72 Very High Very High Very High
Dorsal horn 5 99.68 Very High Very High Very High
Somatostatin 8 98.80 Very High Very High Very High
ischemia 6 96.56 Very High Very High Very High
c fibre 1 92.00 High High
Pain 3 88.16 High High
Neuropeptide 6 83.60 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 4 96.56 Very High Very High Very High
Apoptosis 34 89.92 High High
Hyperoxia 15 84.88 Quite High
Hypoxia 39 83.20 Quite High
Sleep Disorders 1 68.84 Quite High
Aids-related Complex 2 30.96 Quite Low
Death 26 5.00 Very Low Very Low Very Low
Injury 8 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 5 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The highest dose of capsaicin also induced a depletion of BDNF protein in the dorsal horn.
Positive_regulation (induced) of Negative_regulation (depletion) of BDNF protein in dorsal horn associated with qutenza and dorsal horn
1) Confidence 0.70 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11404434 Disease Relevance 0 Pain Relevance 0.80
Four days of once daily oral administration of fluoxetine induced decreases in BDNF mRNA (hippocampus, medial habenular and paraventricular thalamic nuclei).
Positive_regulation (induced) of Negative_regulation (decreases) of BDNF in medial associated with hippocampus and fluoxetine
2) Confidence 0.47 Published 2004 Journal Neuroscience Section Abstract Doc Link 15381288 Disease Relevance 0 Pain Relevance 0.67
A single injection of BDNF elevated SP-LI to a plateau level within 12 hr while NPY-LI and SOM-LI reached maximum levels at 48 hr, and then all returned to control levels at 68 hr.
Positive_regulation (elevated) of Negative_regulation (injection) of BDNF associated with somatostatin and substance p
3) Confidence 0.42 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 7515953 Disease Relevance 0 Pain Relevance 0.74
Our results suggest that the reduction of brain-derived neurotrophic factor messenger RNA induced by monocular deprivation is related to the absence of pattern vision rather than to the competitive interactions that underlie the effects of monocular deprivation during the critical period.
Positive_regulation (induced) of Negative_regulation (reduction) of brain-derived neurotrophic factor in brain
4) Confidence 0.40 Published 1995 Journal Neuroscience Section Abstract Doc Link 8848102 Disease Relevance 0 Pain Relevance 0.08
Thus, the decrease in caspase-3 activity seen in our study after HI could in part be due to BDNF effects.
Positive_regulation (due) of Negative_regulation (effects) of BDNF
5) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000320 Disease Relevance 1.00 Pain Relevance 0.12
Interestingly, BDNF protective effect resulted to be also dependent on MAPKs, as the MEK-1 inhibitor, U-0126, abolished the effect of BDNF without affecting responses to BzATP and NMDA.
Positive_regulation (resulted) of Negative_regulation (effect) of BDNF
6) Confidence 0.27 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.06
Interestingly, BDNF protective effect resulted to be also dependent on MAPKs, as the MEK-1 inhibitor, U-0126, abolished the effect of BDNF without affecting responses to BzATP and NMDA.
Positive_regulation (dependent) of Negative_regulation (effect) of BDNF
7) Confidence 0.27 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.07
Four days of once daily oral administration of fluoxetine induced decreases in BDNF mRNA (hippocampus, medial habenular and paraventricular thalamic nuclei).
Positive_regulation (induced) of in hippocampus Negative_regulation (decreases) of BDNF in medial associated with hippocampus and fluoxetine
8) Confidence 0.16 Published 2004 Journal Neuroscience Section Abstract Doc Link 15381288 Disease Relevance 0 Pain Relevance 0.67

General Comments

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