INT48496

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Context Info
Confidence 0.54
First Reported 1993
Last Reported 2007
Negated 4
Speculated 0
Reported most in Abstract
Documents 16
Total Number 18
Disease Relevance 2.29
Pain Relevance 10.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) nucleus (Th)
response to stress (Th) cytoplasm (Th)
Anatomy Link Frequency
PVN 5
hippocampus 4
peripheral nervous systems 4
brain 2
brainstem 2
Th (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 26 100.00 Very High Very High Very High
Morphine 22 100.00 Very High Very High Very High
Locus ceruleus 17 100.00 Very High Very High Very High
Enkephalin 15 100.00 Very High Very High Very High
Neuropeptide 11 100.00 Very High Very High Very High
Catecholamine 7 100.00 Very High Very High Very High
opioid receptor 6 100.00 Very High Very High Very High
electroacupuncture 4 100.00 Very High Very High Very High
dopamine receptor 4 100.00 Very High Very High Very High
Nucleus accumbens 3 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 16 98.98 Very High Very High Very High
Stress 10 97.40 Very High Very High Very High
Depression 4 95.64 Very High Very High Very High
Morphine Dependence 1 82.92 Quite High
Eating Disorder 1 80.88 Quite High
Convulsion 1 63.32 Quite High
Drug Dependence 3 50.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prolonged cortisol administration failed to alter the mRNA levels of TH, DBH, and NPY in control animals but attenuated the response to stress.
Neg (failed) Regulation (alter) of Transcription (levels) of TH associated with stress
1) Confidence 0.54 Published 1996 Journal Endocrinology Section Abstract Doc Link 8940389 Disease Relevance 0.58 Pain Relevance 0.30
We showed that physiological concentrations of butyrate can regulate transcription of tyrosine hydroxylase (TH) and preproenkephalin (ppEnk) gene in PC12 cells.
Regulation (regulate) of Transcription (transcription) of TH
2) Confidence 0.44 Published 2005 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 16165221 Disease Relevance 0 Pain Relevance 0.03
We showed that physiological concentrations of butyrate can regulate transcription of tyrosine hydroxylase (TH) and preproenkephalin (ppEnk) gene in PC12 cells.
Regulation (regulate) of Transcription (transcription) of tyrosine hydroxylase
3) Confidence 0.44 Published 2005 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 16165221 Disease Relevance 0 Pain Relevance 0.03
The effect of cycloheximide (CHX; 5 mg/kg) on proenkephalin (proENK) and tyrosine hydroxylase (TH) mRNA expression in rat central and peripheral nervous systems was studied.
Regulation (effect) of Transcription (expression) of tyrosine hydroxylase in peripheral nervous systems
4) Confidence 0.43 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 10825388 Disease Relevance 0 Pain Relevance 0.17
The effect of cycloheximide (CHX; 5 mg/kg) on proenkephalin (proENK) and tyrosine hydroxylase (TH) mRNA expression in rat central and peripheral nervous systems was studied.
Regulation (effect) of Transcription (expression) of TH in peripheral nervous systems
5) Confidence 0.43 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 10825388 Disease Relevance 0 Pain Relevance 0.17
The divergent effects of imipramine vs the other 3 antidepressant drugs on Arc NPY mRNA expression are similar to the pattern of changes in tyrosine hydroxylase (TH) mRNA expression levels in the locus coeruleus (LC) using the same experimental paradigm, but are different from the unidirectional depressive effects of all four drugs on CRH mRNA expression in the PVN.
Regulation (changes) of Transcription (levels) of TH in PVN associated with antidepressant, depression, aids-related complex and locus ceruleus
6) Confidence 0.40 Published 1996 Journal J. Neuroendocrinol. Section Abstract Doc Link 8736433 Disease Relevance 0.66 Pain Relevance 0.64
The divergent effects of imipramine vs the other 3 antidepressant drugs on Arc NPY mRNA expression are similar to the pattern of changes in tyrosine hydroxylase (TH) mRNA expression levels in the locus coeruleus (LC) using the same experimental paradigm, but are different from the unidirectional depressive effects of all four drugs on CRH mRNA expression in the PVN.
Regulation (changes) of Transcription (levels) of tyrosine hydroxylase in PVN associated with antidepressant, depression, aids-related complex and locus ceruleus
7) Confidence 0.40 Published 1996 Journal J. Neuroendocrinol. Section Abstract Doc Link 8736433 Disease Relevance 0.66 Pain Relevance 0.64
In the present animal model, cocaine exposure in utero had no significant effect on mRNA levels of the dopamine transporter, D1 or D2 dopamine receptors, enkephalin, tyrosine hydroxylase, or cholecystokinin in juvenile rats.
Neg (no) Regulation (effect) of Transcription (levels) of tyrosine hydroxylase in juvenile associated with dopamine, dopamine receptor, enkephalin, cholecystokinin and cocaine
8) Confidence 0.27 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7909578 Disease Relevance 0.08 Pain Relevance 0.74
Messenger RNA (mRNA) levels for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis, and for precursors to galanin (GAL) and neuropeptide Y (NPY), peptides that coexist with norepinephrine in LC neurons, were not altered by chronic morphine treatment or naloxone-precipitated withdrawal.
Neg (not) Regulation (altered) of Transcription (levels) of TH in neurons associated with locus ceruleus, catecholamine, narcan, neuropeptide, withdrawal and morphine
9) Confidence 0.27 Published 1995 Journal Synapse Section Abstract Doc Link 7540319 Disease Relevance 0.08 Pain Relevance 1.68
EA might regulate the biosynthesis of DA by altering the TH gene transcription.
Regulation (altering) of Transcription (transcription) of TH gene associated with dopamine
10) Confidence 0.27 Published 1999 Journal Acupunct Electrother Res Section Abstract Doc Link 10579240 Disease Relevance 0 Pain Relevance 1.07
In the present study, dot blot technique was applied to observe the effect of noxious stimulation or electroacupuncture on the level of tyrosine hydroxylase (TH) mRNA in rat brain.
Regulation (effect) of Transcription (level) of TH in brain associated with electroacupuncture
11) Confidence 0.27 Published 1999 Journal Acupunct Electrother Res Section Abstract Doc Link 10579240 Disease Relevance 0 Pain Relevance 1.50
In contrast, the basal levels of c-fos and TH mRNAs were not altered in hypox rat adrenal.
Neg (not) Regulation (altered) of Transcription (levels) of TH
12) Confidence 0.26 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8102782 Disease Relevance 0.06 Pain Relevance 0.23
Voluntary ethanol consumption altered mu-opioid receptor function in the cingulate cortex, caudate-putamen (CPu), nucleus accumbens core (Acb C) and shell (Acb S), the expression of tyrosine hydroxylase (TH) in the ventral tegmental area and substantia nigra, proenkephalin (PENK) in the piriform cortex, olfactory tubercle, CPu, Acb C and Acb S, ventromedial nucleus (VMN) and paraventricular nucleus (PVN) of the hypothalamus, corticotropin releasing factor (CRF) in PVN, cannabinoid CB(1) receptor (CB1-R) in the CPu, hippocampus and VMN, and serotonin transporter (5-HTT) in the dorsal and median raphe nuclei.
Regulation (altered) of Transcription (expression) of tyrosine hydroxylase in hippocampus associated with ventral tegmentum, cannabinoid, substantia nigra, opioid receptor, nucleus accumbens, hippocampus, serotonin and raphe
13) Confidence 0.24 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17063152 Disease Relevance 0.05 Pain Relevance 0.51
Both groups of lesioned rats exhibited a similar marked reduction in tyrosine hydroxylase (TH)-mRNA levels, measured by in situ hybridization, in the substantia nigra of the lesioned side.
Regulation (measured) of Transcription (levels) of TH in substantia nigra associated with substantia nigra
14) Confidence 0.21 Published 2000 Journal Life Sci. Section Abstract Doc Link 10794065 Disease Relevance 0 Pain Relevance 0.16
Differential effects of forskolin on tyrosine hydroxylase gene transcription in identified brainstem catecholaminergic neuronal subtypes in organotypic culture.
Regulation (effects) of Transcription (transcription) of tyrosine hydroxylase in brainstem associated with medulla
15) Confidence 0.10 Published 2005 Journal Eur. J. Neurosci. Section Title Doc Link 15787695 Disease Relevance 0 Pain Relevance 0.40
Voluntary ethanol consumption altered mu-opioid receptor function in the cingulate cortex, caudate-putamen (CPu), nucleus accumbens core (Acb C) and shell (Acb S), the expression of tyrosine hydroxylase (TH) in the ventral tegmental area and substantia nigra, proenkephalin (PENK) in the piriform cortex, olfactory tubercle, CPu, Acb C and Acb S, ventromedial nucleus (VMN) and paraventricular nucleus (PVN) of the hypothalamus, corticotropin releasing factor (CRF) in PVN, cannabinoid CB(1) receptor (CB1-R) in the CPu, hippocampus and VMN, and serotonin transporter (5-HTT) in the dorsal and median raphe nuclei.
Regulation (altered) of in CPu Transcription (expression) of tyrosine hydroxylase in hippocampus associated with ventral tegmentum, cannabinoid, substantia nigra, opioid receptor, nucleus accumbens, hippocampus, serotonin and raphe
16) Confidence 0.08 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17063152 Disease Relevance 0.05 Pain Relevance 0.51
Voluntary ethanol consumption altered mu-opioid receptor function in the cingulate cortex, caudate-putamen (CPu), nucleus accumbens core (Acb C) and shell (Acb S), the expression of tyrosine hydroxylase (TH) in the ventral tegmental area and substantia nigra, proenkephalin (PENK) in the piriform cortex, olfactory tubercle, CPu, Acb C and Acb S, ventromedial nucleus (VMN) and paraventricular nucleus (PVN) of the hypothalamus, corticotropin releasing factor (CRF) in PVN, cannabinoid CB(1) receptor (CB1-R) in the CPu, hippocampus and VMN, and serotonin transporter (5-HTT) in the dorsal and median raphe nuclei.
Regulation (altered) of in VMN Transcription (expression) of tyrosine hydroxylase in hippocampus associated with ventral tegmentum, cannabinoid, substantia nigra, opioid receptor, nucleus accumbens, hippocampus, serotonin and raphe
17) Confidence 0.08 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17063152 Disease Relevance 0.05 Pain Relevance 0.51
Effect of morphine on hypothalamic tyrosine hydroxylase mRNA levels in dopaminergic neurons and on preoptic DOPAC levels measured by microdialysis.
Regulation (Effect) of Transcription (levels) of tyrosine hydroxylase in dopaminergic neurons associated with morphine
18) Confidence 0.02 Published 1994 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 7516996 Disease Relevance 0 Pain Relevance 0.69

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