INT48499

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Context Info
Confidence 0.67
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 0.74
Pain Relevance 3.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GNRH1) extracellular space (GNRH1) extracellular region (GNRH1)
cell-cell signaling (GNRH1)
Anatomy Link Frequency
granulosa cells 2
hypothalamus 1
seminiferous tubules 1
GNRH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 79 100.00 Very High Very High Very High
narcan 48 100.00 Very High Very High Very High
Morphine 28 98.86 Very High Very High Very High
Dopamine 20 93.92 High High
antagonist 95 93.84 High High
Opioid 9 75.20 Quite High
Endogenous opioid 4 54.08 Quite High
corticosteroid 16 5.00 Very Low Very Low Very Low
endometriosis 15 5.00 Very Low Very Low Very Low
dexamethasone 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 8 85.56 High High
Ovarian Hyperstimulation Syndrome 33 80.68 Quite High
Obesity 27 75.00 Quite High
Polyploidy 8 68.68 Quite High
Reprotox - General 3 83 50.00 Quite Low
Reprotox - General 2 10 13.92 Low Low
Anovulation 9 11.92 Low Low
Polycystic Ovary Syndrome 33 5.00 Very Low Very Low Very Low
Endometriosis (extended) 30 5.00 Very Low Very Low Very Low
Spontaneous Abortion 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significant increase in FSH (p < 0.001) was only observed during GnRH, GnRH + naloxone and GnRH + aMSH tests (AUCs: placebo 13.3 +/- 1.7; naloxone 14.7 +/- 2.5; alpha-MSH 15.5 +/- 2.3; alpha-MSH + naloxone 16.9 +/- 1.9; GnRH 19.1 +/- 1.1; GnRH + alpha-MSH 20.7 +/- 1.3; GnRH + naloxone 21.2 +/- 1.8 mIU/ml.min-1).
Transcription (observed) of GnRH associated with narcan
1) Confidence 0.67 Published 1997 Journal J. Endocrinol. Invest. Section Abstract Doc Link 9211127 Disease Relevance 0 Pain Relevance 0.66
Significant increase in FSH (p < 0.001) was only observed during GnRH, GnRH + naloxone and GnRH + aMSH tests (AUCs: placebo 13.3 +/- 1.7; naloxone 14.7 +/- 2.5; alpha-MSH 15.5 +/- 2.3; alpha-MSH + naloxone 16.9 +/- 1.9; GnRH 19.1 +/- 1.1; GnRH + alpha-MSH 20.7 +/- 1.3; GnRH + naloxone 21.2 +/- 1.8 mIU/ml.min-1).
Transcription (observed) of GnRH associated with narcan
2) Confidence 0.67 Published 1997 Journal J. Endocrinol. Invest. Section Abstract Doc Link 9211127 Disease Relevance 0 Pain Relevance 0.67
Significant increase in FSH (p < 0.001) was only observed during GnRH, GnRH + naloxone and GnRH + aMSH tests (AUCs: placebo 13.3 +/- 1.7; naloxone 14.7 +/- 2.5; alpha-MSH 15.5 +/- 2.3; alpha-MSH + naloxone 16.9 +/- 1.9; GnRH 19.1 +/- 1.1; GnRH + alpha-MSH 20.7 +/- 1.3; GnRH + naloxone 21.2 +/- 1.8 mIU/ml.min-1).
Transcription (observed) of GnRH associated with narcan
3) Confidence 0.67 Published 1997 Journal J. Endocrinol. Invest. Section Abstract Doc Link 9211127 Disease Relevance 0 Pain Relevance 0.66
In starlings, GnIH receptor (GPR147) mRNA is expressed in GnRH neurons [19] and we demonstrated expression of the GPR147 in human hypothalamus.
Transcription (expressed) of GnRH in hypothalamus
4) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791420 Disease Relevance 0 Pain Relevance 0
Hypothalamic GnRH mRNA expression increased at 3.5 months of age and declined by 6 months of age.
Transcription (expression) of GnRH
5) Confidence 0.52 Published 2006 Journal Soc Reprod Fertil Suppl Section Abstract Doc Link 16866307 Disease Relevance 0.07 Pain Relevance 0.05
An RCT which included 84 participants found no significant difference in pregnancy rate between poor responders treated with either rFSH alone or rLH and FSH in an GnRH agonist flare up protocol.107
Transcription (flare) of GnRH associated with agonist
6) Confidence 0.49 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0.29 Pain Relevance 0.19
GnRH receptors and GnRH receptor mRNA were found to be expressed in human granulosa-luteal cells GnRH receptors have been found in the luteinized human granulosa cells, and a possible direct effect of GnRH on ovarian steroidogenesis has been suggested [485,486].
Transcription (expressed) of GnRH in granulosa cells
7) Confidence 0.41 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.19 Pain Relevance 0.10
GnRH receptors and GnRH receptor mRNA were found to be expressed in human granulosa-luteal cells GnRH receptors have been found in the luteinized human granulosa cells, and a possible direct effect of GnRH on ovarian steroidogenesis has been suggested [485,486].
Transcription (expressed) of GnRH in granulosa cells
8) Confidence 0.41 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.19 Pain Relevance 0.10
Morphine not only suppresses norepinephrine-induced increases in LHRH mRNA levels but, in these same animals, it simultaneously amplifies norepinephrine (NE)-induced LH release.
Transcription (levels) of LHRH associated with morphine
9) Confidence 0.13 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7516996 Disease Relevance 0 Pain Relevance 0.44
These observations suggest that NE may activate parallel mechanisms which independently increase LHRH mRNA levels and LHRH release and suggest that some of these effects could be mediated indirectly via morphine's action on different components of the hypothalamic dopamine (DA) system.
Transcription (levels) of LHRH associated with dopamine and morphine
10) Confidence 0.13 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7516996 Disease Relevance 0 Pain Relevance 0.61
HB carried out the tissue processing and stereological analyses on the seminiferous tubules, MOW carried out the in vivo studies and the Western Blot and ER immunohistochemistry, GRH and RAW carried out the immunostaining for 3?
Transcription (carried) of GRH in seminiferous tubules
11) Confidence 0.04 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0 Pain Relevance 0

General Comments

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