INT4850

Context Info Confidence 0.47 First Reported 1980 Last Reported 2010 Negated 3 Speculated 1 Reported most in Abstract Documents 57 Total Number 59 Disease Relevance 14.25 Pain Relevance 42.17

extracellular space (Tac1) extracellular region (Tac1) plasma membrane (Tac1)

Anatomy Link Frequency spinal cord 5 spinal 4 plasma 2 smooth muscle 2 brain 2 Tac1 (Mus musculus)

Pain Link Frequency Relevance Heat substance P 766 100.00 Pain 73 100.00 adenocard 47 100.00 Serotonin 31 100.00 Opioid 29 100.00 Analgesic 22 100.00 Enkephalin 14 100.00 Neurotransmitter 59 99.98 antagonist 216 99.96 bradykinin 25 99.92

Disease Link Frequency Relevance Heat Depression 190 99.84 Nociception 103 99.84 Pain 67 99.50 Neurogenic Inflammation 21 99.32 INFLAMMATION 287 99.16 Injury 6 98.96 Targeted Disruption 149 97.48 Increased Venous Pressure Under Development 13 95.80 Aids-related Complex 137 94.80 Bordatella Infection 4 94.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Subsequent to its release, substance P binds to neurokinin-1 (NK-1) receptors on the surface of effector cells and, in addition to being a mediator of pain, it plays an important role in many inflammatory states including asthma, immune-complex-mediated lung injury, experimental arthritis, and inflammatory bowel disease.

neurokinin-1 Binding (binds) of in bowel associated with lung injury, asthma, pain, inflammation, experimental arthritis, arthritis and substance p

1) Confidence 0.47 Published 2010 Journal Antioxid. Redox Signal. Section Abstract Doc Link 19803739 Disease Relevance 0.99 Pain Relevance 0.63

We conclude that 1) substance P stimulates extravasation in the gastrointestinal tract and pancreas of mice by interacting with the NK1 receptors, and 2) capsaicin and bradykinin induce plasma extravasation by stimulating tachykinin release from sensory nerves.

NK1 Binding (interacting) of in plasma associated with qutenza, bradykinin and substance p

2) Confidence 0.47 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9142909 Disease Relevance 0.13 Pain Relevance 0.72

These data suggest that the N-terminus of SP is responsible for down-regulation of NK-1 binding.

NK-1 Binding (binding) of associated with substance p

3) Confidence 0.46 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7529387 Disease Relevance 0 Pain Relevance 1.16

Injected intrathecally, substance P (SP) down-regulates neurokinin-1 (NK-1) binding in the spinal cord and desensitizes rats to the behavioral effect of SP.

NK-1 Binding (binding) of in spinal cord associated with spinal cord and substance p

4) Confidence 0.46 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7529387 Disease Relevance 0 Pain Relevance 0.80

An N-terminal fragment of substance P, substance P(1-7), down-regulates neurokinin-1 binding in the mouse spinal cord.

neurokinin-1 Binding (binding) of in spinal cord associated with spinal cord and substance p

5) Confidence 0.46 Published 1994 Journal Neurosci. Lett. Section Title Doc Link 7529387 Disease Relevance 0 Pain Relevance 1.16

Injected intrathecally, substance P (SP) down-regulates neurokinin-1 (NK-1) binding in the spinal cord and desensitizes rats to the behavioral effect of SP.

neurokinin-1 Binding (binding) of in spinal cord associated with spinal cord and substance p

6) Confidence 0.46 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7529387 Disease Relevance 0 Pain Relevance 0.80

The goal of this study was to assess the abilities of N- and C-terminal fragments of SP to down-regulate NK-1 binding.

NK-1 Binding (binding) of associated with substance p

7) Confidence 0.46 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7529387 Disease Relevance 0 Pain Relevance 1.08

As SP(5-11) did not down-regulate NK-1 binding, activation of NK-1 sites does not appear necessary or sufficient for down-regulation of SP binding.

NK-1 Binding (binding) of associated with substance p

8) Confidence 0.46 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7529387 Disease Relevance 0 Pain Relevance 1.15

Subsequent to its release, substance P binds to neurokinin-1 (NK-1) receptors on the surface of effector cells and, in addition to being a mediator of pain, it plays an important role in many inflammatory states including asthma, immune-complex-mediated lung injury, experimental arthritis, and inflammatory bowel disease.

NK-1 Binding (binds) of in bowel associated with lung injury, asthma, pain, inflammation, experimental arthritis, arthritis and substance p

9) Confidence 0.41 Published 2010 Journal Antioxid. Redox Signal. Section Abstract Doc Link 19803739 Disease Relevance 0.99 Pain Relevance 0.63

The present investigation was initiated to determine whether N-terminal fragments interact at binding sites distinct from the neurokinin-1 (NK-1) receptor where the C-terminal sequence of SP binds with high affinity, and distinct from mu-opiate receptors, where we have previously shown the N-terminal sequence of SP to interact.

neurokinin-1 Binding (binds) of associated with opiate and substance p

10) Confidence 0.38 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 1700082 Disease Relevance 0 Pain Relevance 0.77

Based on this report, the present study was conducted to further investigate the direct functional interaction between supraspinal tachykinin (r/m HK-1) and opioid systems.

tachykinin Binding (interaction) of associated with opioid

11) Confidence 0.36 Published 2006 Journal Behav. Brain Res. Section Abstract Doc Link 16621052 Disease Relevance 0.09 Pain Relevance 1.06

At the age of 2 to 4 months, binding of 125I-labelled Tyr8-substance P to synaptic vesicles prepared from different regions of the nervous system was examined.

Tyr8-substance Spec (examined) Binding (binding) of in nervous system associated with substance p

12) Confidence 0.36 Published 1980 Journal J. Neurochem. Section Abstract Doc Link 6161236 Disease Relevance 0 Pain Relevance 0.43

In contrast, SP(1-7), in spite of its inability to interact with NK-1 sites, did down-regulate SP binding, suggesting an indirect mechanism dissociated from NK-1 receptors.

NK-1 Binding (interact) of associated with substance p

13) Confidence 0.35 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7529387 Disease Relevance 0 Pain Relevance 1.08

Substance P and bradykinin stimulated extravasation from postcapillary venules in the stomach, small and large intestine, pancreas, urinary bladder, trachea, and skin by two- to sevenfold by interacting with NK1 and B2 receptors, respectively.

NK1 Binding (interacting) of in urinary bladder associated with bradykinin and substance p

14) Confidence 0.35 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9142909 Disease Relevance 0.16 Pain Relevance 0.69

The present investigation was initiated to determine whether N-terminal fragments interact at binding sites distinct from the neurokinin-1 (NK-1) receptor where the C-terminal sequence of SP binds with high affinity, and distinct from mu-opiate receptors, where we have previously shown the N-terminal sequence of SP to interact.

NK-1 Binding (binds) of associated with opiate and substance p

15) Confidence 0.33 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 1700082 Disease Relevance 0 Pain Relevance 0.77

To test these compounds preclinically, gerbils have become one of the preferred species in that they demonstrate close NK1 receptor homology with humans and bind NK1 antagonists with higher affinity than rats and mice.

NK1 Binding (bind) of associated with antagonist

16) Confidence 0.32 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17912250 Disease Relevance 0 Pain Relevance 0.38

Interactions between serotonin and substance P in the spinal regulation of nociception.

substance P Binding (Interactions) of in spinal associated with nociception, analgesic, serotonin and substance p

17) Confidence 0.28 Published 1991 Journal Brain Res. Section Title Doc Link 1715803 Disease Relevance 0.15 Pain Relevance 0.97

Interactions between 5-hydroxytryptamine (5-HT) and substance P (SP) in the mouse spinal cord were investigated using the tail-flick test and the behavioral response evoked by intrathecal (i.th.)

substance P Binding (Interactions) of in tail associated with tail-flick, intrathecal, spinal cord and substance p

18) Confidence 0.28 Published 1991 Journal Brain Res. Section Abstract Doc Link 1715803 Disease Relevance 0.07 Pain Relevance 0.53

These findings indicate a functional interaction between substance P and 5-HT in the modulation of sensory input at the spinal level.

substance P Binding (interaction) of in spinal associated with substance p

19) Confidence 0.28 Published 1983 Journal Neuropharmacology Section Abstract Doc Link 6198594 Disease Relevance 0.08 Pain Relevance 0.74

Besides SP, peptide hormones such as hemokinin can also bind and activate NK1 at sites of chronic inflammation [44].

NK1 Binding (bind) of associated with inflammation and substance p

20) Confidence 0.28 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817809 Disease Relevance 1.15 Pain Relevance 0.70

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