INT4851

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Context Info
Confidence 0.70
First Reported 1981
Last Reported 2009
Negated 3
Speculated 0
Reported most in Abstract
Documents 53
Total Number 53
Disease Relevance 9.21
Pain Relevance 15.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Chat) transferase activity, transferring acyl groups (Chat)
Anatomy Link Frequency
brain 6
duodenum 5
ileum 2
smooth muscle 2
stomach 2
Chat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 99 100.00 Very High Very High Very High
Enkephalin 29 100.00 Very High Very High Very High
Hippocampus 25 100.00 Very High Very High Very High
substance P 23 100.00 Very High Very High Very High
Neurotransmitter 23 100.00 Very High Very High Very High
Dynorphin 5 100.00 Very High Very High Very High
Somatostatin 2 100.00 Very High Very High Very High
Cholecystokinin 2 100.00 Very High Very High Very High
bradykinin 1 100.00 Very High Very High Very High
Nerve growth factor 14 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 41 100.00 Very High Very High Very High
Anaerobic Bacterial Infections 4 100.00 Very High Very High Very High
Body Weight 4 100.00 Very High Very High Very High
Pain 4 99.48 Very High Very High Very High
Toxicity 9 99.24 Very High Very High Very High
Amnesia 24 99.04 Very High Very High Very High
Alzheimer's Dementia 66 98.72 Very High Very High Very High
Generalized Anxiety Disorder 12 98.08 Very High Very High Very High
Sleep Disorders 2 97.96 Very High Very High Very High
Diverticulitis 87 97.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Choline acetyltransferase activity of grafts increased from 10% of control value at 7 days postgrafting to 55 and 100% at days 28 and 56, respectively.
Positive_regulation (increased) of Choline acetyltransferase
1) Confidence 0.70 Published 1984 Journal J Appl Physiol Section Abstract Doc Link 6725089 Disease Relevance 0 Pain Relevance 0.08
Recently, Yabe et al. have demonstrated that KUT increased both choline acetyltransferase (ChAT) and nerve growth factor at the protein and mRNA levels in cultured rat brain cells.
Positive_regulation (increased) of ChAT in brain associated with nerve growth factor
2) Confidence 0.69 Published 2000 Journal Nippon Ronen Igakkai Zasshi Section Abstract Doc Link 10879069 Disease Relevance 0.45 Pain Relevance 0.11
Recently, Yabe et al. have demonstrated that KUT increased both choline acetyltransferase (ChAT) and nerve growth factor at the protein and mRNA levels in cultured rat brain cells.
Positive_regulation (increased) of choline acetyltransferase in brain associated with nerve growth factor
3) Confidence 0.69 Published 2000 Journal Nippon Ronen Igakkai Zasshi Section Abstract Doc Link 10879069 Disease Relevance 0.45 Pain Relevance 0.11
CAT activity was equal to control in the smooth muscle but elevated two-fold in the submucosa-mucosa at both times.
Positive_regulation (elevated) of CAT in smooth muscle
4) Confidence 0.67 Published 1993 Journal Cell Tissue Res. Section Abstract Doc Link 8095856 Disease Relevance 0 Pain Relevance 0.26
ChAT activity in the FC of aged rats was significantly increased after 5 days of training in an active-avoidance learning task.
Positive_regulation (increased) of ChAT associated with urological neuroanatomy
5) Confidence 0.66 Published 1989 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2623034 Disease Relevance 0.34 Pain Relevance 0.17
ChAT activity in the HC of aged rats was also significantly increased after 6 days of training in a water-filled multiple T-maze.
Positive_regulation (increased) of ChAT associated with hippocampus
6) Confidence 0.66 Published 1989 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2623034 Disease Relevance 0.34 Pain Relevance 0.17
Insulin treatment reversibly reduced ChAT activity in cultures plated at densities of greater than 4,000 cells/mm2, and the extent of this reduction increased with increasing cell density.
Positive_regulation (increased) of ChAT
7) Confidence 0.65 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1629717 Disease Relevance 0.37 Pain Relevance 0.52
The drug also significantly restored decreases in cortical choline acetyltransferase (p < 0.05) and hippocampal glutamic acid decarboxylase activities (p < 0.01) in the embolized cerebral hemisphere and significantly increased cortical choline acetyltransferase (p < 0.05) and acetylcholinesterase activities (p < 0.05) in the contralateral cerebral hemisphere 21 days after embolization.
Positive_regulation (increased) of choline acetyltransferase in cerebral hemisphere
8) Confidence 0.53 Published 1992 Journal Arzneimittelforschung Section Abstract Doc Link 1492838 Disease Relevance 0.38 Pain Relevance 0.27
One hour later, treated animals with their proper control were sacrificed and the mucosa of the stomach, duodenum, ileum and colon were separated and assayed for acetylcholinesterase (AChE) and choline acetyltransferase (ChAT) activities.
Positive_regulation (assayed) of choline acetyltransferase in colon
9) Confidence 0.50 Published 1989 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 2730235 Disease Relevance 0 Pain Relevance 0.39
Sections of rat neostriatum were double-labeled for either choline acetyltransferase (ChAT) and substance P or ChAT and enkephalin using silver intensified colloidal gold and peroxidase as labels.
Positive_regulation (using) of ChAT associated with enkephalin and substance p
10) Confidence 0.50 Published 1992 Journal Brain Res. Section Abstract Doc Link 1280527 Disease Relevance 0 Pain Relevance 0.53
One hour later, treated animals with their proper control were sacrificed and the mucosa of the stomach, duodenum, ileum and colon were separated and assayed for acetylcholinesterase (AChE) and choline acetyltransferase (ChAT) activities.
Positive_regulation (assayed) of ChAT in colon
11) Confidence 0.50 Published 1989 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 2730235 Disease Relevance 0 Pain Relevance 0.39
All stimulated neurones stained for nitric oxide synthase (NOS), vasoactive intestinal polypeptide (VIP) and neuropeptide Y (NPY), but not for choline acetyltransferase (ChAT).
Neg (not) Positive_regulation (stained) of choline acetyltransferase associated with neuropeptide
12) Confidence 0.48 Published 2004 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 15066018 Disease Relevance 0.07 Pain Relevance 0.29
All stimulated neurones stained for nitric oxide synthase (NOS), vasoactive intestinal polypeptide (VIP) and neuropeptide Y (NPY), but not for choline acetyltransferase (ChAT).
Neg (not) Positive_regulation (stained) of ChAT associated with neuropeptide
13) Confidence 0.48 Published 2004 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 15066018 Disease Relevance 0.07 Pain Relevance 0.29
Insulin-like growth factor-1 (IGF-1) reduced ChAT activity at concentrations 10-fold lower than insulin, suggesting that insulin's effect on ChAT may involve the IGF-1 receptor.
Positive_regulation (effect) of ChAT
14) Confidence 0.47 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1629717 Disease Relevance 0.30 Pain Relevance 0.49
NGF increased ChAT activity; TTX had no effect on ChAT activity.
Positive_regulation (increased) of ChAT associated with tetrodotoxin and nerve growth factor
15) Confidence 0.47 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1629717 Disease Relevance 0.29 Pain Relevance 0.49
Decrease of hippocampal choline acetyltransferase activity induced by formalin pain.
Positive_regulation (induced) of choline acetyltransferase associated with pain
16) Confidence 0.47 Published 1993 Journal Brain Res. Section Title Doc Link 8287273 Disease Relevance 0.28 Pain Relevance 0.57
One of these (fraction 4) consistently contained higher levels of choline acetyltransferase activity and hemicholinium-3 sensitive [3H]acetylcholine synthesis than were present in the P2 fraction of the other five subfractions.
Positive_regulation (levels) of choline acetyltransferase
17) Confidence 0.47 Published 1989 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 2746656 Disease Relevance 0 Pain Relevance 0
The most marked early sensorimotor deficits (reflex righting and swimming development) were seen in the 5% soy lecithin preparation group, although all soy lecithin preparation-exposed offspring had elevated brain/body weight ratios and choline acetyltransferase levels.
Positive_regulation (elevated) of choline acetyltransferase in body associated with body weight
18) Confidence 0.47 Published 1985 Journal Dev Psychobiol Section Abstract Doc Link 4038491 Disease Relevance 0.10 Pain Relevance 0.18
There was also significant increase (p less than 0.05) in ChAT activity in the stomach and the duodenum as a result of morphine administration during the light phase, with no effect on other tissues studied.
Positive_regulation (increase) of ChAT in duodenum associated with morphine
19) Confidence 0.46 Published 1989 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 2730235 Disease Relevance 0 Pain Relevance 0.54
For the first time we report that these changes were associated with a compensatory increase in the activity of ChAT (+27%), AChE (+25%), beta-End level (+66%) in the remaining part of the cortex, i.e. cortex devoid of frontal cortex (C-FC).
Positive_regulation (increase) of ChAT in frontal cortex associated with urological neuroanatomy
20) Confidence 0.44 Published 1992 Journal Brain Res. Section Abstract Doc Link 1611500 Disease Relevance 0.23 Pain Relevance 0.48

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