INT48518

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Context Info
Confidence 0.78
First Reported 1994
Last Reported 2010
Negated 4
Speculated 1
Reported most in Abstract
Documents 51
Total Number 52
Disease Relevance 22.88
Pain Relevance 4.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ANPEP) cytosol (ANPEP) peptidase activity (ANPEP)
plasma membrane (ANPEP) cytoplasm (ANPEP)
Anatomy Link Frequency
fibroblast 4
epithelial cells 4
leukocyte 4
stem cells 4
glands 3
ANPEP (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 37 100.00 Very High Very High Very High
Inflammation 35 99.20 Very High Very High Very High
bradykinin 1 97.36 Very High Very High Very High
opioid receptor 1 96.76 Very High Very High Very High
superficial lamina 10 95.08 Very High Very High Very High
agonist 6 94.60 High High
headache 5 92.36 High High
cytokine 35 92.24 High High
Pain 17 90.92 High High
chemokine 12 88.96 High High
Disease Link Frequency Relevance Heat
Cancer 972 99.84 Very High Very High Very High
Obesity 73 99.70 Very High Very High Very High
Prostate Cancer 248 99.40 Very High Very High Very High
INFLAMMATION 48 99.20 Very High Very High Very High
Aging 6 99.20 Very High Very High Very High
Peripheral Arterial Disease 102 98.96 Very High Very High Very High
Metastasis 241 98.84 Very High Very High Very High
Disease 267 98.68 Very High Very High Very High
Necrosis 13 98.18 Very High Very High Very High
Hepatocellular Cancer 87 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
APN/CD13 expression is dysregulated in inflammatory diseases and in cancers (solid and hematologic tumors).
Gene_expression (expression) of APN associated with inflammation, cancer and disease
1) Confidence 0.78 Published 2006 Journal Med Res Rev Section Abstract Doc Link 16216010 Disease Relevance 0.58 Pain Relevance 0.18
OBJECTIVE: To investigate the presence of two enkephalin-degrading enzymes (aminopeptidase N [APN] and neutral endopeptidase 24.11 [NEP]) in different fractions of human semen, their distribution in sperm cells, and their effect on sperm motility.
Spec (investigate) Gene_expression (presence) of aminopeptidase N in semen associated with sperm disorder and enkephalin
2) Confidence 0.76 Published 2008 Journal Fertil. Steril. Section Abstract Doc Link 17953966 Disease Relevance 0.17 Pain Relevance 0.17
CD13 was chosen, because it, like CD10, is a cell surface peptide-processing enzyme (ANPEP, aminopeptidase N) expressed by luminal cells, and a majority of cancer glands were also found not to express CD13.
Gene_expression (expressed) of ANPEP in glands associated with cancer
3) Confidence 0.75 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 0.64 Pain Relevance 0
By flow cytometry, these cells lacked CD45 and expressed CD13/33, CD15, CD34, HLA-DR, and strong CD56.
Gene_expression (expressed) of CD13
4) Confidence 0.75 Published 2006 Journal J. Pediatr. Hematol. Oncol. Section Abstract Doc Link 17114955 Disease Relevance 1.17 Pain Relevance 0.09
Extracellular cysteines define ectopeptidase (APN, CD13) expression and function.
Gene_expression (expression) of CD13
5) Confidence 0.75 Published 2002 Journal Free Radic. Biol. Med. Section Title Doc Link 11909693 Disease Relevance 0 Pain Relevance 0.17
APN/CD13 expression is dysregulated in inflammatory diseases and in cancers (solid and hematologic tumors).
Gene_expression (expression) of CD13 associated with inflammation, cancer and disease
6) Confidence 0.75 Published 2006 Journal Med Res Rev Section Abstract Doc Link 16216010 Disease Relevance 0.58 Pain Relevance 0.18
Aminopeptidase N (APN)/CD13 (EC 3.4.11.2) is a transmembrane protease present in a wide variety of human tissues and cell types (endothelial, epithelial, fibroblast, leukocyte).
Gene_expression (present) of APN in leukocyte
7) Confidence 0.67 Published 2006 Journal Med Res Rev Section Abstract Doc Link 16216010 Disease Relevance 0.41 Pain Relevance 0.11
The APN exists in two forms, namely the membrane aminopeptidase N and the soluble aminopeptidase N.
Gene_expression (exists) of aminopeptidase N
8) Confidence 0.66 Published 2007 Journal Curr. Med. Chem. Section Abstract Doc Link 17346152 Disease Relevance 0.07 Pain Relevance 0.07
The APN exists in two forms, namely the membrane aminopeptidase N and the soluble aminopeptidase N.
Gene_expression (exists) of aminopeptidase N
9) Confidence 0.66 Published 2007 Journal Curr. Med. Chem. Section Abstract Doc Link 17346152 Disease Relevance 0.13 Pain Relevance 0.13
Aminopeptidase N (APN)/CD13 (EC 3.4.11.2) is a transmembrane protease present in a wide variety of human tissues and cell types (endothelial, epithelial, fibroblast, leukocyte).
Gene_expression (present) of CD13 in leukocyte
10) Confidence 0.65 Published 2006 Journal Med Res Rev Section Abstract Doc Link 16216010 Disease Relevance 0.41 Pain Relevance 0.11
Aminopeptidase N (APN)/CD13 (EC 3.4.11.2) is a transmembrane protease present in a wide variety of human tissues and cell types (endothelial, epithelial, fibroblast, leukocyte).
Gene_expression (present) of Aminopeptidase N in leukocyte
11) Confidence 0.65 Published 2006 Journal Med Res Rev Section Abstract Doc Link 16216010 Disease Relevance 0.41 Pain Relevance 0.11
APN is a ubiquitous enzyme present in a wide variety of human organs, tissues and cell types (endothelial, epithelial, fibroblast, leukocyte).
Gene_expression (present) of APN in leukocyte
12) Confidence 0.59 Published 2007 Journal Curr. Med. Chem. Section Abstract Doc Link 17346152 Disease Relevance 0.15 Pain Relevance 0.15
NGR-hTNF is a vascular-targeting agent consisting of human tumour necrosis factor-alpha fused to the tumour-homing peptide NGR, which is able to selectively bind an aminopeptidase N overexpressed on tumour blood vessels.


Gene_expression (overexpressed) of aminopeptidase N in blood vessels associated with necrosis and cancer
13) Confidence 0.58 Published 2010 Journal Br J Cancer Section Abstract Doc Link PMC2966632 Disease Relevance 0.99 Pain Relevance 0
with the tumour-homing peptide asparagine–glycine–arginine (NGR), which is able to selectively bind an aminopeptidase N (CD13) isoform overexpressed by endothelial cells of many tumours, including HCC (Arap et al, 1998; Curnis et al, 2000; Corti and Ponzoni, 2004).
Gene_expression (overexpressed) of CD13 in endothelial cells associated with cancer and hepatocellular cancer
14) Confidence 0.58 Published 2010 Journal Br J Cancer Section Body Doc Link PMC2966632 Disease Relevance 0.97 Pain Relevance 0.04
with the tumour-homing peptide asparagine–glycine–arginine (NGR), which is able to selectively bind an aminopeptidase N (CD13) isoform overexpressed by endothelial cells of many tumours, including HCC (Arap et al, 1998; Curnis et al, 2000; Corti and Ponzoni, 2004).
Gene_expression (overexpressed) of aminopeptidase N in endothelial cells associated with cancer and hepatocellular cancer
15) Confidence 0.58 Published 2010 Journal Br J Cancer Section Body Doc Link PMC2966632 Disease Relevance 0.98 Pain Relevance 0.04
The APN exists in two forms, namely the membrane aminopeptidase N and the soluble aminopeptidase N.
Gene_expression (exists) of APN
16) Confidence 0.57 Published 2007 Journal Curr. Med. Chem. Section Abstract Doc Link 17346152 Disease Relevance 0.07 Pain Relevance 0.07
This was paralleled by a loss in cell surface expression of APN at physiological (10(-10) M) concentrations of MENK.
Gene_expression (expression) of APN associated with enkephalin
17) Confidence 0.53 Published 1999 Journal Immunopharmacology Section Abstract Doc Link 9950265 Disease Relevance 0 Pain Relevance 0.85
Immunohistochemical staining reveals that macrophages in tenosynovial tissues express CD13, CD14, CD33, HLA-DR, and CD68 antigens on their surfaces and express interleukin (IL)-1 beta, tumor necrosis factor (TNF)-alpha, and IL-6.
Gene_expression (express) of CD13 in macrophages associated with necrosis and cancer
18) Confidence 0.39 Published 2001 Journal Semin Dial Section Abstract Doc Link 11264784 Disease Relevance 0.83 Pain Relevance 0.12
CD13 was chosen, because it, like CD10, is a cell surface peptide-processing enzyme (ANPEP, aminopeptidase N) expressed by luminal cells, and a majority of cancer glands were also found not to express CD13.
Neg (not) Gene_expression (express) of CD13 in glands associated with cancer
19) Confidence 0.39 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 0.58 Pain Relevance 0
Normal epithelium present in the specimens showed the characteristic strong CD10 and CD13 expression at the luminal plasma membrane.
Gene_expression (expression) of CD13 in epithelium
20) Confidence 0.39 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 1.16 Pain Relevance 0

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