INT4853

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Context Info
Confidence 0.45
First Reported 1981
Last Reported 2008
Negated 1
Speculated 5
Reported most in Abstract
Documents 42
Total Number 47
Disease Relevance 22.34
Pain Relevance 16.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Hrh2) signal transducer activity (Hrh2)
Anatomy Link Frequency
liver 2
blood 1
covering 1
esophageal sphincter 1
cerebrospinal fluid 1
Hrh2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 248 100.00 Very High Very High Very High
antagonist 119 100.00 Very High Very High Very High
peptic ulcer disease 24 100.00 Very High Very High Very High
anesthesia 7 100.00 Very High Very High Very High
aspirin 4 100.00 Very High Very High Very High
Clonidine 8 99.98 Very High Very High Very High
agonist 5 99.96 Very High Very High Very High
nociceptor 2 99.84 Very High Very High Very High
Arthritis 7 99.52 Very High Very High Very High
Analgesic 2 99.38 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ulcers 194 100.00 Very High Very High Very High
Disease 37 100.00 Very High Very High Very High
INFLAMMATION 19 100.00 Very High Very High Very High
Gastroesophageal Reflux Disease 45 99.84 Very High Very High Very High
Arthritis 7 99.52 Very High Very High Very High
Recurrence 5 99.40 Very High Very High Very High
Infection 22 99.24 Very High Very High Very High
Hepatotoxicity 11 99.20 Very High Very High Very High
Toxicity 7 99.02 Very High Very High Very High
Duodenal Ulcer 16 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of H2-receptor antagonists on steady-state extraction of indocyanine green and lidocaine by the perfused rat liver.
Regulation (Effect) of H2-receptor in liver associated with antagonist and lidocaine
1) Confidence 0.45 Published 1986 Journal J. Lab. Clin. Med. Section Title Doc Link 2868064 Disease Relevance 0 Pain Relevance 0.71
We studied the effect of proton pump inhibitors, histamine H(2) receptor antagonists, and other types of antacid drugs on fracture risk.
Regulation (effect) of histamine H associated with antagonist
2) Confidence 0.44 Published 2006 Journal Calcif. Tissue Int. Section Abstract Doc Link 16927047 Disease Relevance 0.12 Pain Relevance 0.24
[Effect of H2 histamine receptor blocking agents on the isolated lower esophageal sphincter (LES) of the rat].
Regulation ([Effect) of H2 histamine receptor in esophageal sphincter
3) Confidence 0.44 Published 1981 Journal Farmaco Sci Section Title Doc Link 6112158 Disease Relevance 0 Pain Relevance 0.16
Effects of H2 receptor antagonists on the hepatotoxicity of various chemicals.
Regulation (Effects) of H2 receptor associated with antagonist and hepatotoxicity
4) Confidence 0.44 Published 1984 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Title Doc Link 6147001 Disease Relevance 0.35 Pain Relevance 0.38
With respect to acute gastrointestinal bleeding, however, two well-conducted trials indicate that an intravenous proton pump inhibitor is significantly more effective than an intravenous histamine-2-receptor antagonist or placebo in reducing the rate of rebleeding after hemostasis in patients with bleeding peptic ulcer.
Regulation (effective) of histamine-2-receptor associated with antagonist, ulcers and hemorrhage
5) Confidence 0.44 Published 2002 Journal Crit. Care Med. Section Abstract Doc Link 12072665 Disease Relevance 1.56 Pain Relevance 0.16
The effects of a new H2-receptor antagonist, roxatidine acetate, have been investigated in both clinical and pharmacodynamic trials in Europe and the United States.
Regulation (effects) of H2-receptor associated with antagonist
6) Confidence 0.41 Published 1989 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 2572621 Disease Relevance 0 Pain Relevance 0.05
Effects of histamine-2 receptor blockade on lidocaine kinetics.
Regulation (Effects) of histamine-2 associated with lidocaine
7) Confidence 0.41 Published 1985 Journal Clin. Pharmacol. Ther. Section Title Doc Link 3987178 Disease Relevance 0 Pain Relevance 0.57
Our data strongly suggest that in some central effects clonidine affects both alpha 2 and H2 receptor mechanism.
Regulation (affects) of H2 receptor associated with clonidine
8) Confidence 0.40 Published 1984 Journal Pol J Pharmacol Pharm Section Abstract Doc Link 6089156 Disease Relevance 0.06 Pain Relevance 0.50
Changes in surgical strategies for peptic ulcers before and after the introduction of H2-receptor antagonists and endoscopic hemostasis.
Regulation (introduction) of H2-receptor associated with antagonist and ulcers
9) Confidence 0.40 Published 1995 Journal Surg. Today Section Title Doc Link 7633122 Disease Relevance 0.96 Pain Relevance 0.19
A total of 902 surgical patients with peptic ulcer disease were evaluated to clarify the effects of H2-receptor antagonists and endoscopic hemostasis on surgical treatment.
Regulation (effects) of H2-receptor associated with antagonist, peptic ulcer disease and disease
10) Confidence 0.40 Published 1995 Journal Surg. Today Section Abstract Doc Link 7633122 Disease Relevance 0.47 Pain Relevance 0.19
Therefore, in the present study, the mortality rate of the disease was evaluated in Finland during the past 17 years covering the dramatic change in the medical therapy: the introduction of H2-receptor antagonists.
Regulation (introduction) of H2-receptor in covering associated with antagonist and disease
11) Confidence 0.40 Published 1995 Journal Dig. Dis. Sci. Section Abstract Doc Link 7895558 Disease Relevance 1.20 Pain Relevance 0.39
It also summarizes a study that investigated whether H2-receptor antagonists and antacids affect the development of serious GI complications.
Spec (whether) Regulation (affect) of H2-receptor associated with antagonist
12) Confidence 0.40 Published 1999 Journal J Rheumatol Suppl Section Abstract Doc Link 10225536 Disease Relevance 0.62 Pain Relevance 0.62
It also describes differences among NSAID with regard to their GI toxicity and describes a study that investigated whether H2-receptor antagonists and antacids affect the development of serious GI complications.
Spec (whether) Regulation (affect) of H2-receptor associated with toxicity, antagonist and cinod
13) Confidence 0.40 Published 1998 Journal J Rheumatol Suppl Section Abstract Doc Link 9596549 Disease Relevance 0.94 Pain Relevance 0.67
The current study suggests that the frequency of high-risk patients requiring surgery is increasing since the introduction of H2-receptor antagonists and endoscopic hemostasis, and thus, prompt surgical treatment and intensive management for such patients is essential.
Regulation (introduction) of H2-receptor associated with antagonist
14) Confidence 0.40 Published 1995 Journal Surg. Today Section Abstract Doc Link 7633122 Disease Relevance 0.87 Pain Relevance 0.11
Lansoprazole was more effective than H2-receptor antagonists in patients with Zollinger-Ellison syndrome and produced similar treatment outcome to omeprazole.
Regulation (effective) of H2-receptor associated with syndrome and antagonist
15) Confidence 0.40 Published 2001 Journal Expert Opin Pharmacother Section Abstract Doc Link 11825309 Disease Relevance 1.17 Pain Relevance 0.40
OBJECTIVES: To determine prospectively the effect of aspirin, nonsteroidal anti-inflammatory drugs, H2-receptor antagonists, proton pump inhibitors, alcohol intake, race, age, history of Helicobacter pylori eradication attempts, and gastric biopsy location on CLOtest performance.
Regulation (effect) of H2-receptor associated with aspirin, inflammation, antagonist, ulcers, cinod and alcohol
16) Confidence 0.40 Published 1997 Journal Am. J. Gastroenterol. Section Abstract Doc Link 9260796 Disease Relevance 0.20 Pain Relevance 0.25
It further analyses 2 drug classes and their effects on the gastrointestinal tract, histamine H 2-receptor antagonists, which have a positive impact on clinical effects and resource use, and NSAIDs, which have negative effects.
Spec (analyses) Regulation (effects) of histamine H 2-receptor associated with antagonist and cinod
17) Confidence 0.39 Published 1992 Journal Pharmacoeconomics Section Abstract Doc Link 10150155 Disease Relevance 0.26 Pain Relevance 0.36
This study was undertaken to determine the effects of two H2-receptor antagonists, cimetidine and ranitidine, on halothane metabolism and hepatotoxicity in the hypoxic Fisher 344 rat model for halothane hepatitis.
Spec (determine) Regulation (effects) of H2-receptor associated with hypoxia, antagonist, hepatotoxicity, halothane and hepatitis
18) Confidence 0.37 Published 1984 Journal Drug Metab. Dispos. Section Abstract Doc Link 6141900 Disease Relevance 0.45 Pain Relevance 0.38
The histamine H2-receptor antagonist ranitidine has been shown to be effective in preventing NSAID-induced duodenal ulcers, but has no efficacy in preventing NSAID-induced gastric ulcers.
Regulation (effective) of H2-receptor associated with antagonist, duodenal ulcer, cinod and peptic ulcer
19) Confidence 0.36 Published 1995 Journal Dig Dis Section Abstract Doc Link 7697902 Disease Relevance 1.08 Pain Relevance 1.20
These differences lead to differences in the degree and duration of acid inhibition: repeated doses of proton-pump inhibitors are needed in order to reach the maximum antisecretory effect, whereas the acid-inhibitory effect of H2-receptor antagonists is achieved within hours, although it tends to fade during prolonged treatment.
Regulation (effect) of H2-receptor associated with antagonist
20) Confidence 0.34 Published 1996 Journal Eur J Gastroenterol Hepatol Section Abstract Doc Link 8930573 Disease Relevance 0.68 Pain Relevance 0.40

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