INT48540

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Context Info
Confidence 0.77
First Reported 1994
Last Reported 2011
Negated 0
Speculated 3
Reported most in Abstract
Documents 37
Total Number 40
Disease Relevance 14.04
Pain Relevance 16.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Kcna5) plasma membrane (Kcna5) transmembrane transport (Kcna5)
Anatomy Link Frequency
choroid plexus 6
spinal cord 5
neuronal 3
DRG 3
memory T cells 2
Kcna5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
potassium channel 47 100.00 Very High Very High Very High
antagonist 6 99.88 Very High Very High Very High
diclofenac 28 99.78 Very High Very High Very High
Inflammation 42 99.70 Very High Very High Very High
Spinal cord 132 99.52 Very High Very High Very High
dorsal root ganglion 72 99.44 Very High Very High Very High
Snapping jaw 16 99.44 Very High Very High Very High
Morphine 25 99.42 Very High Very High Very High
Nav1.7 3 98.52 Very High Very High Very High
qutenza 17 98.38 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 48 99.70 Very High Very High Very High
Ganglion Cysts 131 99.44 Very High Very High Very High
Temporomandibular Joint Syndrome 16 99.44 Very High Very High Very High
Middle Cerebral Artery Infarction 7 99.00 Very High Very High Very High
Autoimmune Disease 12 98.96 Very High Very High Very High
Neuroblastoma 4 98.52 Very High Very High Very High
Alzheimer's Dementia 10 98.20 Very High Very High Very High
Neuropathic Pain 60 97.52 Very High Very High Very High
Hypoxia 13 97.16 Very High Very High Very High
Drug Induced Neurotoxicity 2 96.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we focused on the effect of chronic morphine exposure on voltage-dependent Shaker-related Kv1.5 and Kv1.6 K+ channel gene expression and on Kv1.5 protein levels in the rat spinal cord.
Gene_expression (expression) of Kv1 in spinal cord associated with spinal cord and morphine
1) Confidence 0.77 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8872310 Disease Relevance 0 Pain Relevance 0.78
Chronic morphine administration enhances the expression of Kv1.5 and Kv1.6 voltage-gated K+ channels in rat spinal cord.
Gene_expression (expression) of Kv1 in spinal cord associated with spinal cord and morphine
2) Confidence 0.77 Published 1996 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 8872310 Disease Relevance 0 Pain Relevance 0.80
Chronic morphine administration enhances the expression of Kv1.5 and Kv1.6 voltage-gated K+ channels in rat spinal cord.
Gene_expression (expression) of Kv1 in spinal cord associated with spinal cord and morphine
3) Confidence 0.77 Published 1996 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 8872310 Disease Relevance 0 Pain Relevance 0.80
In this study, we focused on the effect of chronic morphine exposure on voltage-dependent Shaker-related Kv1.5 and Kv1.6 K+ channel gene expression and on Kv1.5 protein levels in the rat spinal cord.
Gene_expression (expression) of Kv1 in spinal cord associated with spinal cord and morphine
4) Confidence 0.77 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8872310 Disease Relevance 0 Pain Relevance 0.79
We have analyzed the biophysical and pharmacological properties of five cloned K+ (Kv) channels (Kv1.1, Kv1.2, Kv1.3, Kv1.5, and Kv3.1) stably expressed in mammalian cell lines.
Gene_expression (expressed) of Kv1
5) Confidence 0.76 Published 1994 Journal Mol. Pharmacol. Section Abstract Doc Link 7517498 Disease Relevance 0.09 Pain Relevance 0
We have analyzed the biophysical and pharmacological properties of five cloned K+ (Kv) channels (Kv1.1, Kv1.2, Kv1.3, Kv1.5, and Kv3.1) stably expressed in mammalian cell lines.
Gene_expression (expressed) of Kv1
6) Confidence 0.76 Published 1994 Journal Mol. Pharmacol. Section Abstract Doc Link 7517498 Disease Relevance 0.09 Pain Relevance 0
We have analyzed the biophysical and pharmacological properties of five cloned K+ (Kv) channels (Kv1.1, Kv1.2, Kv1.3, Kv1.5, and Kv3.1) stably expressed in mammalian cell lines.
Gene_expression (expressed) of Kv1
7) Confidence 0.76 Published 1994 Journal Mol. Pharmacol. Section Abstract Doc Link 7517498 Disease Relevance 0.09 Pain Relevance 0
We have analyzed the biophysical and pharmacological properties of five cloned K+ (Kv) channels (Kv1.1, Kv1.2, Kv1.3, Kv1.5, and Kv3.1) stably expressed in mammalian cell lines.
Gene_expression (expressed) of Kv1
8) Confidence 0.76 Published 1994 Journal Mol. Pharmacol. Section Abstract Doc Link 7517498 Disease Relevance 0.09 Pain Relevance 0
RNase protection assay revealed that Kv1.1 and Kv 1.2 mRNAs are highly abundant while Kv1.3, Kv1.4, Kv1.5 and Kv1.6 mRNAs were detected at lower levels in L4-L5 DRGs from sham and intact rats.
Gene_expression (detected) of Kv1
9) Confidence 0.68 Published 2004 Journal Neuroscience Section Abstract Doc Link 14751280 Disease Relevance 0.50 Pain Relevance 0.42
RNase protection assay revealed that Kv1.1 and Kv 1.2 mRNAs are highly abundant while Kv1.3, Kv1.4, Kv1.5 and Kv1.6 mRNAs were detected at lower levels in L4-L5 DRGs from sham and intact rats.
Gene_expression (detected) of Kv1
10) Confidence 0.68 Published 2004 Journal Neuroscience Section Abstract Doc Link 14751280 Disease Relevance 0.50 Pain Relevance 0.42
RNase protection assay revealed that Kv1.1 and Kv 1.2 mRNAs are highly abundant while Kv1.3, Kv1.4, Kv1.5 and Kv1.6 mRNAs were detected at lower levels in L4-L5 DRGs from sham and intact rats.
Gene_expression (detected) of Kv1
11) Confidence 0.68 Published 2004 Journal Neuroscience Section Abstract Doc Link 14751280 Disease Relevance 0.50 Pain Relevance 0.42
RNase protection assay revealed that Kv1.1 and Kv 1.2 mRNAs are highly abundant while Kv1.3, Kv1.4, Kv1.5 and Kv1.6 mRNAs were detected at lower levels in L4-L5 DRGs from sham and intact rats.
Gene_expression (detected) of Kv1
12) Confidence 0.68 Published 2004 Journal Neuroscience Section Abstract Doc Link 14751280 Disease Relevance 0.50 Pain Relevance 0.42
In this study, we focused on the effect of chronic morphine exposure on voltage-dependent Shaker-related Kv1.5 and Kv1.6 K+ channel gene expression and on Kv1.5 protein levels in the rat spinal cord.
Gene_expression (levels) of Kv1 in spinal cord associated with spinal cord and morphine
13) Confidence 0.67 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8872310 Disease Relevance 0 Pain Relevance 0.78
These results suggest that Kv1.1 and Kv1.2 subunits are major components of voltage-gated K+ channels in L4-L5 DRG neurons and that the decreased expression of Kv1-family subunits significantly contributes to the reduction and altered kinetics of Kv current in axotomized neurons.
Gene_expression (expression) of Kv1 in neurons associated with dorsal root ganglion
14) Confidence 0.60 Published 2004 Journal Neuroscience Section Abstract Doc Link 14751280 Disease Relevance 0.49 Pain Relevance 0.31
In the present study, we used immunocytochemical methods to investigate the expression of Kv channels (Kv1.1, 1.2, 1.3, 1.4, 1.5, 1.6, and 2.1) in DRG cells cultured from control and axotomized adult rats.
Spec (investigate) Gene_expression (expression) of Kv1 in DRG associated with dorsal root ganglion and potassium channel
15) Confidence 0.60 Published 1999 Journal Muscle Nerve Section Abstract Doc Link 10204786 Disease Relevance 0.85 Pain Relevance 0.69
Fluoxetine (10 mg/kg per day) reduced the expression of Bcl-2 and Bcl-xL protein, increased the expression of cleaved caspase 3 protein and enhanced the expression of Kv1.5 protein and mRNA in pulmonary arteries.
Gene_expression (expression) of Kv1 associated with fluoxetine
16) Confidence 0.59 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19298536 Disease Relevance 1.01 Pain Relevance 0.68
A double immunofluorescence method also revealed co-expression of Kv1.2 and parvalbumin.
Gene_expression (expression) of Kv1
17) Confidence 0.58 Published 2003 Journal Brain Res. Section Abstract Doc Link 12742640 Disease Relevance 0.58 Pain Relevance 0.31
While diclofenac inhibited Kv1.3 expression in activated macrophages and T-lymphocytes, Kv1.5 remained unaffected.
Gene_expression (expression) of Kv1 in T-lymphocytes associated with diclofenac
18) Confidence 0.57 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20488163 Disease Relevance 0.45 Pain Relevance 0.65
Patients with autoimmune diseases show a high number of effector memory T cells that are characterized by a high expression of Kv1.3 and Kv1.3 antagonists ameliorate autoimmune disorders in vivo.
Gene_expression (expression) of Kv1 in memory T cells associated with autoimmune disease and antagonist
19) Confidence 0.57 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20488163 Disease Relevance 0.46 Pain Relevance 0.55
Patients with autoimmune diseases show a high number of effector memory T cells that are characterized by a high expression of Kv1.3 and Kv1.3 antagonists ameliorate autoimmune disorders in vivo.
Gene_expression (expression) of Kv1 in memory T cells associated with autoimmune disease and antagonist
20) Confidence 0.57 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20488163 Disease Relevance 0.46 Pain Relevance 0.55

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