INT48542

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Context Info
Confidence 0.77
First Reported 1994
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 6.53
Pain Relevance 7.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Kcna3)
Anatomy Link Frequency
neuronal 4
interneurons 2
dorsal root ganglion 2
spinal cord 1
L929 1
Kcna3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 28 99.72 Very High Very High Very High
Neuropathic pain 8 99.28 Very High Very High Very High
Serotonin 4 99.04 Very High Very High Very High
potassium channel 16 98.84 Very High Very High Very High
fluoxetine 15 98.78 Very High Very High Very High
intrathecal 4 98.36 Very High Very High Very High
GABAergic 9 98.08 Very High Very High Very High
Glutamate receptor 10 97.92 Very High Very High Very High
Pain 22 97.44 Very High Very High Very High
Spinal nerve ligature 4 96.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 28 99.72 Very High Very High Very High
Nociception 9 99.40 Very High Very High Very High
Neuropathic Pain 8 99.28 Very High Very High Very High
Hypoxia 12 98.94 Very High Very High Very High
Pain 14 97.44 Very High Very High Very High
Targeted Disruption 8 95.56 Very High Very High Very High
Hypersensitivity 12 94.92 High High
Glioma 1 93.68 High High
Increased Venous Pressure Under Development 2 75.92 Quite High
Frailty 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of fluoxetine and its major metabolite, norfluoxetine, were studied using the patch-clamp technique on the cloned neuronal rat K(+) channel Kv3.1, expressed in Chinese hamster ovary cells.
Gene_expression (expressed) of Kv3 in ovary associated with fluoxetine
1) Confidence 0.77 Published 2001 Journal Neuropharmacology Section Abstract Doc Link 11543764 Disease Relevance 0 Pain Relevance 0.39
After Kv3.4 or Kv4.3 expression in lumbar DRG neurons was suppressed by intrathecal injections of antisense oligodeoxynucleotides, mechanical but not thermal hypersensitivity developed.
Gene_expression (expression) of Kv3 in neurons associated with dorsal root ganglion, hypersensitivity and intrathecal
2) Confidence 0.64 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17855600 Disease Relevance 1.22 Pain Relevance 1.02
Most Kv4.3(+) DRG neurons also expressed Kv3.4.
Gene_expression (expressed) of Kv3 in DRG associated with dorsal root ganglion
3) Confidence 0.64 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17855600 Disease Relevance 1.24 Pain Relevance 1.02
Kv3.4 was expressed mainly in the nociceptive DRG neurons, in their somata, axons, and nerve terminals innervating the dorsal horn of spinal cord.
Gene_expression (expressed) of Kv3 in spinal cord associated with nociception, dorsal root ganglion, dorsal horn and spinal cord
4) Confidence 0.64 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17855600 Disease Relevance 1.16 Pain Relevance 0.84
To test this hypothesis, we first characterized the expression of two A-channels, Kv3.4 and Kv4.3, in rat dorsal root ganglion (DRG) neurons.
Gene_expression (expression) of Kv3 in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
5) Confidence 0.64 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17855600 Disease Relevance 1.07 Pain Relevance 0.81
Among the observed differences that may relate to functional specialization in neuronal firing and/or synaptic integration are the diverse expression of genes coding for three voltage gated potassium channels in MNs and dCINs: Kv1.1 is more expressed in MNs whereas Kv3.1 and Kv1.4 are more expressed in dCINs.
Gene_expression (expressed) of Kv3 in neuronal associated with potassium channel
6) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566599 Disease Relevance 0.06 Pain Relevance 0.76
The action of fluoxetine, a serotonin reuptake inhibitor, on the cloned neuronal rat Kv3.1 channels stably expressed in Chinese hamster ovary cells was investigated using the whole-cell patch-clamp technique.
Gene_expression (expressed) of Kv3 in neuronal associated with serotonin and fluoxetine
7) Confidence 0.53 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18187934 Disease Relevance 0 Pain Relevance 0.42
Hypoxia failed to inhibit any Kv1 channel, but it inhibited Kv3.1b channels expressed in L929 cells, as shown by a reduction of whole-cell current and single-channel activity, without affecting unitary conductance.
Gene_expression (expressed) of Kv3 in L929 associated with hypoxia
8) Confidence 0.36 Published 2000 Journal Circ. Res. Section Abstract Doc Link 10720415 Disease Relevance 0.56 Pain Relevance 0.06
Using reverse transcription-polymerase chain reaction and immunocytochemistry, Kv3.1b expression was demonstrated in PASM cells.
Gene_expression (expression) of Kv3 in PASM
9) Confidence 0.36 Published 2000 Journal Circ. Res. Section Abstract Doc Link 10720415 Disease Relevance 0.51 Pain Relevance 0.09
We now describe the role of neuronal activity and neurotrophins for Kv3.1b/3.2 expression using organotypic cultures of rat visual cortex as model system.
Gene_expression (expression) of Kv3 in neuronal
10) Confidence 0.35 Published 2008 Journal Neuroscience Section Abstract Doc Link 18775767 Disease Relevance 0.10 Pain Relevance 0.23
Neuronal activity and TrkB ligands influence Kv3.1b and Kv3.2 expression in developing cortical interneurons.
Gene_expression (expression) of Kv3 in interneurons
11) Confidence 0.35 Published 2008 Journal Neuroscience Section Title Doc Link 18775767 Disease Relevance 0.08 Pain Relevance 0.22
Neuronal activity and TrkB ligands influence Kv3.1b and Kv3.2 expression in developing cortical interneurons.
Gene_expression (expression) of Kv3 in interneurons
12) Confidence 0.35 Published 2008 Journal Neuroscience Section Title Doc Link 18775767 Disease Relevance 0.08 Pain Relevance 0.22
BDNF and NT4 supplemented from 2 DIV onwards increased the expression of Kv3.1b, but not Kv3.2 mRNA in young cultures.
Gene_expression (expression) of Kv3
13) Confidence 0.35 Published 2008 Journal Neuroscience Section Abstract Doc Link 18775767 Disease Relevance 0.07 Pain Relevance 0.23
The results show that Kv3.1b/3.2 expression is differentially controlled by neuronal activity and neurotrophic factors.
Gene_expression (expression) of Kv3 in neuronal
14) Confidence 0.35 Published 2008 Journal Neuroscience Section Abstract Doc Link 18775767 Disease Relevance 0.05 Pain Relevance 0.11
However, chronic activity deprivation failed to alter Kv3.1b and marginally delayed Kv3.2 protein expression.
Gene_expression (expression) of Kv3
15) Confidence 0.27 Published 2008 Journal Neuroscience Section Abstract Doc Link 18775767 Disease Relevance 0.08 Pain Relevance 0.25
However, chronic activity deprivation failed to alter Kv3.1b and marginally delayed Kv3.2 protein expression.
Gene_expression (expression) of Kv3
16) Confidence 0.27 Published 2008 Journal Neuroscience Section Abstract Doc Link 18775767 Disease Relevance 0.08 Pain Relevance 0.25
BDNF and NT4 supplemented from 2 DIV onwards increased the expression of Kv3.1b, but not Kv3.2 mRNA in young cultures.
Gene_expression (expression) of Kv3
17) Confidence 0.27 Published 2008 Journal Neuroscience Section Abstract Doc Link 18775767 Disease Relevance 0.07 Pain Relevance 0.23
We have analyzed the biophysical and pharmacological properties of five cloned K+ (Kv) channels (Kv1.1, Kv1.2, Kv1.3, Kv1.5, and Kv3.1) stably expressed in mammalian cell lines.
Gene_expression (expressed) of Kv3
18) Confidence 0.12 Published 1994 Journal Mol. Pharmacol. Section Abstract Doc Link 7517498 Disease Relevance 0.09 Pain Relevance 0

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