INT48554

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Context Info
Confidence 0.49
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 3.64
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (SP1) nucleus (SP1) intracellular (SP1)
DNA binding (SP1) transcription factor binding (SP1) cytoplasm (SP1)
Anatomy Link Frequency
proximal 2
colon 1
neurons 1
SP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 2 99.68 Very High Very High Very High
narcan 1 93.28 High High
orphanin 2 88.32 High High
mu opioid receptor 7 82.36 Quite High
agonist 7 82.08 Quite High
Cannabinoid receptor 2 80.32 Quite High
opioid receptor 1 79.20 Quite High
tolerance 4 77.96 Quite High
Kinase C 5 77.92 Quite High
Inflammation 45 76.00 Quite High
Disease Link Frequency Relevance Heat
Immunotherapy Of Cancer 2 98.40 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 147 97.92 Very High Very High Very High
Colon Cancer 11 97.68 Very High Very High Very High
Death 10 96.84 Very High Very High Very High
Herpes Simplex Virus 238 95.40 Very High Very High Very High
Adhesions 53 94.88 High High
Cancer 37 92.96 High High
Hypoxia 1 88.88 High High
Familial Adenomatous Polyposis 8 88.40 High High
Apoptosis 16 86.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NF-kappaB activation was not a nonspecific response of all transcription factors because neither Sp1 or Oct1 was activated in patients with activated NF-kappaB.
Neg (neither) Positive_regulation (activated) of Sp1
1) Confidence 0.49 Published 1998 Journal Circulation Section Body Doc Link 9788823 Disease Relevance 0 Pain Relevance 0
Stimulation with morphine was capable of up-regulating the intracellular level of Sp1 and YY1 proteins.
Positive_regulation (up-regulating) of Sp1 associated with morphine
2) Confidence 0.48 Published 2008 Journal J. Cell. Biochem. Section Abstract Doc Link 17990281 Disease Relevance 0 Pain Relevance 0.43
The induction of NAG-1 promoter activity by LYR-8 was strongly correlated with increased Sp1 activation as noted in various luc-promoter activities.
Positive_regulation (activation) of Sp1
3) Confidence 0.46 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20230799 Disease Relevance 0.89 Pain Relevance 0.24
These results suggest that induction of NAG-1 via Sp1 activation is a promising therapeutic approach in cancer treatment, and that a novel compound like LYR-8 could be a potent chemotherapeutic agent for colon cancers including p53-mutated cancer.
Positive_regulation (activation) of Sp1 in colon associated with cancer, colon cancer and immunotherapy of cancer
4) Confidence 0.46 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20230799 Disease Relevance 1.06 Pain Relevance 0.10
Upregulation of GRK2 correlated with increases in levels of transcription factors Sp1 or AP-2.
Positive_regulation (increases) of Sp1
5) Confidence 0.30 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12423667 Disease Relevance 0.08 Pain Relevance 0.35
The SP1 topographic pattern showed little or no change across the innocuous and noxious stimulus levels, which together with the amplitude data suggests that SP1 is largely generated by neurons involved in innocuous somatosensation.
Positive_regulation (generated) of SP1 in neurons
6) Confidence 0.24 Published 1994 Journal Electroencephalogr Clin Neurophysiol Section Abstract Doc Link 7517852 Disease Relevance 0 Pain Relevance 0
s promoter in human myometrial cells is modulated by hCG in a biphasic manner by a mechanism that appears to involve PRKA activation of SP1 [51].


Positive_regulation (activation) of SP1
7) Confidence 0.21 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892059 Disease Relevance 0 Pain Relevance 0.04
It is interesting to note that some of the PGE2 activated transcription factors (Sp1, HIF-1?
Positive_regulation (factors) of Sp1
8) Confidence 0.16 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.58 Pain Relevance 0.04
Sp1 and Sp4 are transcriptional activators, whereas Sp3 has been classified as a repressor of HIV-1 transcription.
Positive_regulation (activators) of Sp1 associated with acquired immune deficiency syndrome or hiv infection
9) Confidence 0.16 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.37 Pain Relevance 0
At the level of transcriptional regulation, changes in the levels of cellular binding of the transcription factors Sp-1 and AP-2 to their cognate response DNA sequences contained within the proximal promoter region of the gene of a cartilage matrix component, aggrecan, are indeed the targets of TGF-?
Positive_regulation (factors) of Sp-1 in proximal
10) Confidence 0.06 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.27 Pain Relevance 0
At the level of transcriptional regulation, changes in the levels of cellular binding of the transcription factors Sp-1 and AP-2 to their cognate response DNA sequences contained within the proximal promoter region of the gene of a cartilage matrix component, aggrecan, are indeed the targets of TGF-?
Positive_regulation (cellular) of Sp-1 in proximal
11) Confidence 0.06 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.27 Pain Relevance 0
Mutant DMPK transcripts bind and sequester transcription factors such as Specificity protein 1 leading to reduced transcription of selected genes.
Positive_regulation (leading) of Specificity protein 1
12) Confidence 0.02 Published 2008 Journal Current Genomics Section Abstract Doc Link PMC2694559 Disease Relevance 0.13 Pain Relevance 0

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