INT48562

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Context Info
Confidence 0.44
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.88
Pain Relevance 4.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
spinal 4
neurons 2
synapses 2
cortex 2
interneurons 2


Pain Term Frequency Confidence Heat
Glutamate receptor 18 100.00 Very High Very High Very High
Dopamine 4 100.00 Very High Very High Very High
agonist 4 100.00 Very High Very High Very High
medulla 11 99.56 Very High Very High Very High
Anterior cingulate cortex 63 99.32 Very High Very High Very High
Dorsal horn neuron 15 99.00 Very High Very High Very High
qutenza 29 98.36 Very High Very High Very High
tail-flick 4 98.20 Very High Very High Very High
projection neuron 4 96.92 Very High Very High Very High
Glutamate 48 94.64 High High
Disease Term Frequency Confidence Heat
Nociception 36 99.72 Very High Very High Very High
Pain 57 91.32 High High
Urological Neuroanatomy 5 90.20 High High
Targeted Disruption 32 83.32 Quite High
Injury 25 71.48 Quite High
Anxiety Disorder 10 57.44 Quite High
Hyperalgesia 2 52.08 Quite High
INFLAMMATION 4 48.00 Quite Low
Neuropathic Pain 19 33.28 Quite Low
Toxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of metabotropic glutamate receptors differentially affects two classes of hippocampal interneurons and potentiates excitatory synaptic transmission.
Regulation (affects) of Positive_regulation (Activation) of glutamate receptors in interneurons associated with glutamate receptor
1) Confidence 0.44 Published 1994 Journal J. Neurosci. Section Title Doc Link 7517996 Disease Relevance 0 Pain Relevance 0.48
To help define the role of these MAP kinases in neuronal signalling, we have used primary cultures derived from fetal rat cortex to assess the regulation of their activity by agonist stimulation of glutamate receptors and by synaptic activity.
Regulation (regulation) of Positive_regulation (stimulation) of glutamate receptors in cortex associated with glutamate receptor and agonist
2) Confidence 0.44 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 7693864 Disease Relevance 0 Pain Relevance 0.21
Furthermore, striatonigral and striatopallidal pathways are differentially regulated by the activation of dopamine or glutamate receptors.
Regulation (regulated) of Positive_regulation (activation) of glutamate receptors associated with dopamine and glutamate receptor
3) Confidence 0.44 Published 2005 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 15927758 Disease Relevance 0 Pain Relevance 0.60
Several mechanisms may contribute to synaptic enhancement:

(1) postsynaptic regulation of glutamate receptors, including phosphorylation and dephosphorylation; (2) recruitment of functional glutamate receptors (for example, in spinal dorsal horn neurons, recruitment of postsynaptic functional AMPA receptors);

(3) presynaptic enhancement of glutamate release;

(4) structural changes in synapses.

Regulation (regulation) of Positive_regulation (recruitment) of glutamate receptors in synapses associated with glutamate, glutamate receptor and dorsal horn neuron
4) Confidence 0.44 Published 2007 Journal Mol Pain Section Body Doc Link PMC1904186 Disease Relevance 0.63 Pain Relevance 0.82
The present study has examined the effects of electrical stimulation and chemical activation of metabotropic glutamate receptors (mGluRs) in the ACC on a spinal nociceptive tail-flick (TF) reflex induced by noxious heating.
Spec (examined) Regulation (effects) of Spec (examined) Positive_regulation (activation) of glutamate receptors in spinal associated with nociception, glutamate receptor, tail-flick and anterior cingulate cortex
5) Confidence 0.26 Published 2000 Journal Eur J Pain Section Abstract Doc Link 10833558 Disease Relevance 0.62 Pain Relevance 1.24
Peripheral noxious stimulation, such as capsaicin injection, causes an increased responsiveness in spinal nociceptive neurons that involve the activation of glutamate receptors.
Regulation (involve) of Positive_regulation (activation) of glutamate receptors in spinal associated with nociception, qutenza and glutamate receptor
6) Confidence 0.26 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.42 Pain Relevance 0.64
The PBC is located in the rostroventrolateral medulla, and its neurons are dependent on activation of glutamate receptors (N-methyl D-asperate (NMDA) and non-NMDA) to depolarize.
Regulation (dependent) of Positive_regulation (activation) of glutamate receptors in neurons associated with medulla and glutamate receptor
7) Confidence 0.26 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.22 Pain Relevance 0.19

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