INT48567

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Context Info
Confidence 0.51
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 2.44
Pain Relevance 4.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Drd1a) plasma membrane (Drd1a) nucleus (Drd1a)
intracellular (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
dorsal 1
Drd1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 195 100.00 Very High Very High Very High
dopamine receptor 37 100.00 Very High Very High Very High
Neuropeptide 10 100.00 Very High Very High Very High
Enkephalin 10 100.00 Very High Very High Very High
substance P 5 100.00 Very High Very High Very High
Dynorphin 2 100.00 Very High Very High Very High
Somatostatin 3 99.62 Very High Very High Very High
gABA 27 98.78 Very High Very High Very High
Hippocampus 4 97.40 Very High Very High Very High
Inflammation 52 94.72 High High
Disease Link Frequency Relevance Heat
Schizophrenia 2 98.88 Very High Very High Very High
Nociception 26 97.68 Very High Very High Very High
INFLAMMATION 52 94.72 High High
Inflammatory Pain 6 94.48 High High
Generalized Anxiety Disorder 2 90.56 High High
Depression 3 88.16 High High
Neuropathic Pain 4 86.12 High High
Cognitive Disorder 3 84.48 Quite High
Pain 40 74.44 Quite High
Diabetic Neuropathy 2 36.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The D1 dopamine receptor (D1R) mRNA level was not significantly modified after either treatment.
Transcription (level) of D1 dopamine receptor associated with dopamine receptor
1) Confidence 0.51 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7518029 Disease Relevance 0 Pain Relevance 0.37
Isolated and group housed Flinders Sensitive Line rats had higher levels of dopamine D1 receptor and substance P and enkephalin but not dynorphin mRNAs when compared with Sprague-Dawley rats.
Transcription (levels) of dopamine D1 receptor associated with dopamine, dynorphin, enkephalin and substance p
2) Confidence 0.43 Published 2007 Journal Neuroreport Section Abstract Doc Link 17558292 Disease Relevance 0.09 Pain Relevance 0.59
In order to investigate whether early VH lesion in rats alters the expression of genes implicated in schizophrenia pre- and post-puberty, we studied the mRNA expression of neuropeptides (substance P, dynorphin and enkephalin), dopamine D1, dopamine D2, and NMDA (subunits NR1 and NR2A) receptors in this animal model.
Transcription (expression) of dopamine D1 associated with dopamine, dynorphin, neuropeptide, enkephalin, hippocampus, schizophrenia and substance p
3) Confidence 0.42 Published 2009 Journal Schizophr. Res. Section Abstract Doc Link 19500946 Disease Relevance 0.27 Pain Relevance 0.64
In its dorsal part, GABA is possibly colocalized with somatostatin, and many neurons express the dopamine-1-receptor subtype mRNA.
Transcription (express) of dopamine-1-receptor in dorsal associated with dopamine, gaba and somatostatin
4) Confidence 0.30 Published 1998 Journal Adv Anat Embryol Cell Biol Section Abstract Doc Link 9586282 Disease Relevance 0.18 Pain Relevance 0.53
Quantitative densitometry was used to measure changes in mRNA levels for preproenkephalin A (ENK), D1 dopamine receptor, protachykinin (SubP), glutamic acid decarboxylase (GAD65), and D2 dopamine receptor.
Transcription (levels) of D1 dopamine receptor associated with dopamine receptor
5) Confidence 0.27 Published 1998 Journal Brain Res. Section Abstract Doc Link 9630515 Disease Relevance 0 Pain Relevance 0.32
mRNA levels of dopamine D1 and D2 receptors in the IC
Transcription (levels) of dopamine D1 associated with dopamine
6) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC2994804 Disease Relevance 0.80 Pain Relevance 0.70
Given the relationship between dopamine, its receptors and nociceptive modulation in the IC, we decided to measure the release of dopamine and its metabolites (DOPAC and HVA) as well as dopamine D1 and D2 receptors' mRNA expression.
Transcription (expression) of dopamine D1 associated with nociception and dopamine
7) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC2994804 Disease Relevance 1.10 Pain Relevance 1.27
Postsynaptic D1-receptor localization has been suggested, on the basis of the detection of D1-receptor mRNA (Fremeau Jr. et al., 1991).
Transcription (detection) of D1-receptor
8) Confidence 0.07 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0 Pain Relevance 0.13

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