INT48568

Context Info Confidence 0.06 First Reported 1994 Last Reported 2006 Negated 2 Speculated 0 Reported most in Abstract Documents 3 Total Number 4 Disease Relevance 0 Pain Relevance 2.64

Anatomy Link Frequency neurons 1 caudate-putamen 1 Kcnk2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat dopamine receptor 6 99.96 opioid receptor 18 99.90 substance P 3 96.96 Morphine 7 96.76 Dopamine 9 90.84 Neuropeptide 3 89.20 cocaine 4 82.16 midbrain 1 81.44 Substantia nigra 1 79.52 Opioid 2 78.40

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The present data provide ultrastructural evidence for co-existence between DOR and D1R in striatal neurons, suggesting a possible mechanism whereby D1R modulation may alter DOR function.

Regulation (modulation) of D1R in neurons associated with opioid receptor

1) Confidence 0.06 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16517070 Disease Relevance 0 Pain Relevance 0.67

Dual immunoperoxidase/gold-silver detection combined with electron microscopy was used to identify DOR and D1R immunoreactivities in the same section of tissue.

Regulation (immunoreactivities) of D1R associated with opioid receptor

2) Confidence 0.06 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16517070 Disease Relevance 0 Pain Relevance 0.76

As reported previously by others, there was no alteration in D1R mRNA and a 25% decrease in D2R mRNA in the caudate-putamen, 2 h after the final morphine injection.

Neg (no) Regulation (alteration) of D1R in caudate-putamen associated with morphine

3) Confidence 0.01 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12654507 Disease Relevance 0 Pain Relevance 0.84

The D1 dopamine receptor (D1R) mRNA level was not significantly modified after either treatment.

Neg (not) Regulation (modified) of D1R associated with dopamine receptor

4) Confidence 0.00 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7518029 Disease Relevance 0 Pain Relevance 0.37

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