INT4857

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Context Info
Confidence 0.62
First Reported 1980
Last Reported 2010
Negated 11
Speculated 19
Reported most in Abstract
Documents 115
Total Number 135
Disease Relevance 39.01
Pain Relevance 84.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tacr1) response to stress (Tacr1) cytoplasm (Tacr1)
signal transducer activity (Tacr1)
Anatomy Link Frequency
spinal cord 11
neurons 11
sensory neurons 6
spinal 5
brain 5
Tacr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 1088 100.00 Very High Very High Very High
dorsal root ganglion 306 100.00 Very High Very High Very High
Spinal cord 274 100.00 Very High Very High Very High
qutenza 264 100.00 Very High Very High Very High
Pain 250 100.00 Very High Very High Very High
antagonist 229 100.00 Very High Very High Very High
Inflammation 176 100.00 Very High Very High Very High
bradykinin 68 100.00 Very High Very High Very High
agonist 65 100.00 Very High Very High Very High
Neuropeptide 52 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 328 100.00 Very High Very High Very High
Nociception 319 100.00 Very High Very High Very High
INFLAMMATION 180 100.00 Very High Very High Very High
Stress 80 100.00 Very High Very High Very High
Depression 47 100.00 Very High Very High Very High
Arthritis 43 100.00 Very High Very High Very High
Hypoxia 17 100.00 Very High Very High Very High
Cv General 4 Under Development 7 100.00 Very High Very High Very High
Aging 2 100.00 Very High Very High Very High
Headache 2 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of rats with the selective NK-1R antagonist LY306,740 was used to determine the role of NK-1R activation in the regulation of nociception-induced NK-1R mRNA levels.
Regulation (regulation) of NK-1R mRNA associated with nociception and antagonist
1) Confidence 0.62 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8913350 Disease Relevance 0.32 Pain Relevance 0.26
We also examined whether neurokinin-1 receptor distributions in one or both regions are affected by (1) startle-evoking intense auditory stimulation or (2) acute administration of apomorphine, a dopamine D1/D2 agonist that enhances startle while paradoxically reducing the prepulse inhibition produced by low intensity conditioning stimuli in rat models of schizophrenia.
Spec (whether) Regulation (affected) of neurokinin-1 associated with dopamine, agonist and schizophrenia
2) Confidence 0.60 Published 2005 Journal Neuroscience Section Abstract Doc Link 16165296 Disease Relevance 0.17 Pain Relevance 0.44
This study was undertaken to assess changes in NK-1 receptor mRNA levels in models of persistent inflammatory hyperalgesia and to relate them to changes in the functional coupling of NK-1 receptors to G-protein activity in the dorsal horn of the rat.
Regulation (changes) of NK-1 receptor mRNA in dorsal horn associated with hyperalgesia, inflammation and dorsal horn
3) Confidence 0.58 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15985614 Disease Relevance 0.42 Pain Relevance 0.35
However, neither SSCS exposure nor capsaicin pretreatment affects the immunolabeling density of neurokinin-1 receptor (NK-1R) in airway epithelium.
Neg (neither) Regulation (affects) of NK-1R in epithelium associated with qutenza
4) Confidence 0.49 Published 2004 Journal Toxicology Section Abstract Doc Link 15297018 Disease Relevance 0.38 Pain Relevance 1.01
However, neither SSCS exposure nor capsaicin pretreatment affects the immunolabeling density of neurokinin-1 receptor (NK-1R) in airway epithelium.
Neg (neither) Regulation (affects) of neurokinin-1 receptor in epithelium associated with qutenza
5) Confidence 0.49 Published 2004 Journal Toxicology Section Abstract Doc Link 15297018 Disease Relevance 0.38 Pain Relevance 1.01
The distribution and density of binding sites were similar in vehicle- and capsaicin-pretreated rats, suggesting that sensory neuron ablation by neonatal capsaicin does not affect tachykinin receptor numbers in the rat caudal brainstem.
Neg (not) Regulation (affect) of tachykinin receptor in brainstem associated with medulla and qutenza
6) Confidence 0.46 Published 2003 Journal Brain Res. Section Abstract Doc Link 12850591 Disease Relevance 0 Pain Relevance 0.52
Effect of the NK-1 receptor antagonist GR 82,334 on reflexly-induced bladder contractions.
Regulation (Effect) of NK-1 receptor in bladder associated with qutenza and antagonist
7) Confidence 0.45 Published 1992 Journal Life Sci. Section Title Doc Link 1335533 Disease Relevance 0.17 Pain Relevance 0.37
Importantly, inflammation does not induce a phenotypic change in afferent sensory neurons providing neurokinin receptor targets for the direct sensitization of these neurons by substance P.
Regulation (sensitization) of neurokinin receptor in sensory neurons associated with inflammation and substance p
8) Confidence 0.45 Published 1999 Journal Neuroscience Section Abstract Doc Link 10430499 Disease Relevance 0.26 Pain Relevance 0.54
This study reports experiments designed to evaluate the role of neurokinin-1 (NK1) receptors for substance P (SP) in the ventilatory response to acute hypoxia.
Regulation (role) of neurokinin-1 associated with hypoxia and substance p
9) Confidence 0.45 Published 1994 Journal J. Appl. Physiol. Section Abstract Doc Link 7519186 Disease Relevance 0.23 Pain Relevance 0.28
We have examined the effects of intrathecally (i.t.) administered CP-96,345, a non-peptide NK1 receptor ligand, on the spinal nociceptive flexor reflex and on the facilitation of this reflex evoked by i.t. substance P (SP), neurokinin A (NKA) and electrical conditioning stimulation of cutaneous C-afferents.
Spec (examined) Regulation (effects) of NK1 receptor in spinal associated with nociception and substance p
10) Confidence 0.45 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1385160 Disease Relevance 0.10 Pain Relevance 0.25
In the present study, the NK1-receptor antagonist ezlopitant is effective in attenuating both sucrose and ethanol intake in rodents.
Regulation (effective) of NK1-receptor associated with antagonist
11) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931709 Disease Relevance 0 Pain Relevance 0.44
To further evaluate ezlopitant's selectivity for sweet solutions, we tested the effect of the NK1-receptor antagonist on water and salty (NaCl) solution intake, respectively.
Regulation (effect) of NK1-receptor associated with antagonist
12) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931709 Disease Relevance 0 Pain Relevance 0.23
These results indicate that selective NK1 receptor antagonists could be potentially effective for the treatment of migraine headache.
Regulation (effective) of NK1 receptor associated with migraine, antagonist and headache
13) Confidence 0.45 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7691624 Disease Relevance 0.17 Pain Relevance 0.50
To assess their putative role in respiratory responses to hypoxia, neurokinin-1, and mu-opioid receptor binding was determined in the respiratory nucleus tractus solitarius of the mature rat after single and recurrent intermittent hypoxia versus normoxia.
Regulation (role) of neurokinin-1 in respiratory associated with hypoxia and opioid receptor
14) Confidence 0.45 Published 2003 Journal Brain Res. Bull. Section Abstract Doc Link 12464404 Disease Relevance 0.50 Pain Relevance 0.21
Neonatal capsaicin treatment affects rat thymocyte proliferation and cell death by modulating substance P and neurokinin-1 receptor expression.
Regulation (modulating) of neurokinin-1 receptor in thymocyte associated with qutenza, death and substance p
15) Confidence 0.45 Published 2004 Journal Neuroimmunomodulation Section Title Doc Link 15067207 Disease Relevance 0.43 Pain Relevance 1.25
Overall, our results strongly suggest that the immunomodulatory effects of neonatal CPS treatment on rat thymocyte functions are dependent on vanilloid-mediated regulation of SP and NK-1R functional expression by neuronal and immune cells.
Regulation (regulation) of NK-1R in neuronal associated with qutenza and substance p
16) Confidence 0.45 Published 2004 Journal Neuroimmunomodulation Section Abstract Doc Link 15067207 Disease Relevance 0.19 Pain Relevance 1.12
Effects of FR 113680 and FK 224, novel tachykinin receptor antagonists, on cigarette smoke-induced rat tracheal plasma extravasation.
Regulation (Effects) of tachykinin receptor in plasma associated with antagonist
17) Confidence 0.44 Published 1992 Journal Eur. J. Pharmacol. Section Title Doc Link 1280594 Disease Relevance 0 Pain Relevance 0.20
We have studied the effects and interactions of the neurokinin-1 receptor antagonist CP-96,345 and the N-methyl-D-aspartate receptor/channel blocker MK-801, both applied intravenously, on the flexor reflex and on the facilitation of the flexor reflex by conditioning stimulation of cutaneous C-afferents in decerebrate, spinalized, unanesthetized rats.
Regulation (effects) of neurokinin-1 receptor associated with nmda receptor and antagonist
18) Confidence 0.44 Published 1992 Journal Neuroscience Section Abstract Doc Link 1283208 Disease Relevance 0.07 Pain Relevance 0.28
They suggest that while apomorphine can independently affect neurokinin-1 receptor trafficking in substantia nigra motor circuits, its effects on neurokinin-1 receptor distributions in the ventral tegmental area are exclusively dependent on sensory activation.
Regulation (affect) of neurokinin-1 in ventral associated with ventral tegmentum and substantia nigra
19) Confidence 0.44 Published 2005 Journal Neuroscience Section Abstract Doc Link 16165296 Disease Relevance 0.06 Pain Relevance 0.31
They suggest that while apomorphine can independently affect neurokinin-1 receptor trafficking in substantia nigra motor circuits, its effects on neurokinin-1 receptor distributions in the ventral tegmental area are exclusively dependent on sensory activation.
Regulation (effects) of neurokinin-1 in ventral associated with ventral tegmentum and substantia nigra
20) Confidence 0.44 Published 2005 Journal Neuroscience Section Abstract Doc Link 16165296 Disease Relevance 0.05 Pain Relevance 0.25

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