INT48593
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Therapeutic stimulation of penile nitric oxide synthase (NOS) and related pathways. | |||||||||||||||
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The increased NOS immunoreactivities could be antagonized by pre-treatment with sumatriptan. | |||||||||||||||
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N(2)O stimulates NOS enzyme activity in C57BL/6 but not DBA/2 mice. | |||||||||||||||
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Therapeutic stimulation of penile nitric oxide synthase (NOS) and related pathways. | |||||||||||||||
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There are three NOS isoforms, endothelial cell NOS (eNOS), neuronal NOS (nNOS), and inducible NOS (iNOS). | |||||||||||||||
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The activation of neuronal NO synthase (nNOS) and other Ca2+ -dependant enzymes may account for many of the beneficial as well as deleterious affects associated with NMDA receptor activation, including neuronal development (Garthwaite 1991), learning, and memory (Iga et al 1993), but also cell death and neurodegeneration (Dawson VL and Dawson TM 1995).
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The activation of neuronal NO synthase (nNOS) and other Ca2+ -dependant enzymes may account for many of the beneficial as well as deleterious affects associated with NMDA receptor activation, including neuronal development (Garthwaite 1991), learning, and memory (Iga et al 1993), but also cell death and neurodegeneration (Dawson VL and Dawson TM 1995).
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Inducible NOS like immunoreactivity was detected in decidualised stromal cells and also expressed in tissues from first trimester of pregnancy. | |||||||||||||||
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Inducible NOS isoform is elevated in tissues of patients with endometriosis [131]. | |||||||||||||||
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Expression of inducible NOS was highest in patients with preterm pregnancy and not in patients in term labor. | |||||||||||||||
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Significant increase in the levels of serum metabolites of NOS amongst users of progestin only contraceptives has been reported [120]. | |||||||||||||||
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The types of NOS are classified as endothelial NOS (eNOS; NOS3), which regulates vascular function; inducible NOS (iNOS; NOS2), which is present in vasculature but is also involved in immune responses; and neuronal NOS (nNOS; NOS1), which is present predominantly in the peripheral and central nervous systems. eNOS and nNOS are the constitutive forms of NOS. | |||||||||||||||
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NOS phosphorylation in some other brain regions, which may be regulated by PKA, probably contributes to the increase of NOS activity in morphine-dependent mice. | |||||||||||||||
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Although the presence of neuronal nitric oxide synthase (nNOS) has been demonstrated in human clitoral corpus cavernosum, functional evidence for the nitrergic neurotransmission as a nonadrenergic noncholinergic (NANC) transmitter has been limited to animal studies. | |||||||||||||||
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The activity of the constitutive NOS depends on Ca2+ and calmodulin, whereas the inducible NOS is independent of Ca2+. | |||||||||||||||
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Thus, while an initial activation of constitutive NOS may follow acute stress (De Oliveira et al 2000), iNOS appears to play a more prominent role during chronic stress (Homayoun et al 2002). | |||||||||||||||
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This suggests that overproduction of NO in the hippocampus following TDS stress more likely is the result of iNOS induction and not activation of nNOS. | |||||||||||||||
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Indeed, activation of NOS by TDS stress is selectively blocked by the selective iNOS inhibitor, aminoguanidine and not the selective nNOS inhibitor, 7-nitroindazole (Harvey et al 2004). | |||||||||||||||
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An interesting observation was the ability of KCZ to increase the dissociation constant (Km) of hippocampal NOS. | |||||||||||||||
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In this work, we examined physiological and morphological evidence for nitric oxide synthase (NOS) activation in the chronic constriction injury model of neuropathic pain in rats. | |||||||||||||||
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General Comments
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