INT4860

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Context Info
Confidence 0.00
First Reported 1981
Last Reported 2011
Negated 9
Speculated 2
Reported most in Abstract
Documents 148
Total Number 154
Disease Relevance 73.35
Pain Relevance 97.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CALCA) aging (CALCA) extracellular region (CALCA)
nucleus (CALCA) intracellular (CALCA) cell-cell signaling (CALCA)
Anatomy Link Frequency
plasma 14
blood 7
trigeminal ganglion 6
nerves 6
tears 2
CALCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 3450 100.00 Very High Very High Very High
Neuropeptide 574 100.00 Very High Very High Very High
qutenza 370 100.00 Very High Very High Very High
substance P 366 100.00 Very High Very High Very High
antagonist 330 100.00 Very High Very High Very High
Inflammation 296 100.00 Very High Very High Very High
headache 235 100.00 Very High Very High Very High
Inflammatory mediators 38 100.00 Very High Very High Very High
calcitonin gene related peptide 36 100.00 Very High Very High Very High
Spinal cord 21 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Headache 668 100.00 Very High Very High Very High
INFLAMMATION 302 100.00 Very High Very High Very High
Hypersensitivity 201 100.00 Very High Very High Very High
Neurogenic Inflammation 40 100.00 Very High Very High Very High
Heart Rate Under Development 30 100.00 Very High Very High Very High
Metabolic Bone Disease 1 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 196 99.96 Very High Very High Very High
Migraine Disorders 68 99.92 Very High Very High Very High
Hyperamylasemia 2 99.90 Very High Very High Very High
Fever 5 99.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The CGRP1 receptor subtype antagonist, hCGRP(8-37), increased by 29+/-8% the EFS-evoked contractions and significantly reduced the response to 0.1 microM CGRP.
Positive_regulation (increased) of hCGRP associated with antagonist and calcitonin gene-related peptide
1) Confidence 0.00 Published 2001 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11521167 Disease Relevance 0 Pain Relevance 0.76
Single administration of cetraxate caused significant increases in plasma CGRP concentration at 60-120 min compared with placebo.
Positive_regulation (increases) of CGRP in plasma associated with calcitonin gene-related peptide
2) Confidence 0.70 Published 2004 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 15099451 Disease Relevance 0.07 Pain Relevance 0.71
No increase of calcitonin gene-related peptide in jugular blood during migraine.
Neg (No) Positive_regulation (increase) of calcitonin gene-related peptide in blood associated with migraine and calcitonin gene-related peptide
3) Confidence 0.70 Published 2005 Journal Ann. Neurol. Section Title Doc Link 16178016 Disease Relevance 0.45 Pain Relevance 0.73
Increased calcitonin gene-related peptide (CGRP) in external jugular venous blood during migraine attack is one of the most cited findings in the headache literature.
Positive_regulation (Increased) of CGRP in blood associated with migraine, headache and calcitonin gene-related peptide
4) Confidence 0.70 Published 2005 Journal Ann. Neurol. Section Abstract Doc Link 16178016 Disease Relevance 0.40 Pain Relevance 0.58
Our finding strongly suggests that CGRP is not increased in jugular venous blood during migraine without aura.
Neg (not) Positive_regulation (increased) of CGRP in blood associated with migraine and calcitonin gene-related peptide
5) Confidence 0.70 Published 2005 Journal Ann. Neurol. Section Abstract Doc Link 16178016 Disease Relevance 0.17 Pain Relevance 0.62
Thus, previous findings of increased CGRP level in external jugular or cubital fossa venous blood could not be confirmed.
Positive_regulation (increased) of CGRP in blood associated with calcitonin gene-related peptide
6) Confidence 0.70 Published 2005 Journal Ann. Neurol. Section Abstract Doc Link 16178016 Disease Relevance 0.16 Pain Relevance 0.63
Increased calcitonin gene-related peptide (CGRP) in external jugular venous blood during migraine attack is one of the most cited findings in the headache literature.
Positive_regulation (Increased) of calcitonin gene-related peptide in blood associated with migraine, headache and calcitonin gene-related peptide
7) Confidence 0.70 Published 2005 Journal Ann. Neurol. Section Abstract Doc Link 16178016 Disease Relevance 0.40 Pain Relevance 0.57
These results indicate that the majority of CGRP-IR found in the trigeminal nucleus originates from trigeminal primary afferents and that an upregulation of CGRP-IR occurs in trigeminal motoneurons and in regenerating fibers in the part of the central root that was still attached to the ganglion.
Positive_regulation (upregulation) of CGRP-IR in nucleus associated with ganglion cysts and calcitonin gene-related peptide
8) Confidence 0.70 Published 1996 Journal J. Comp. Neurol. Section Abstract Doc Link 8742300 Disease Relevance 0.23 Pain Relevance 0.57
Rhizotomy induced a dramatic increase in CGRP-IR within trigeminal motoneurons and their fibers, which was strongest 10 days after rhizotomy and weaker at 30 days, which was still stronger than normal.
Positive_regulation (increase) of CGRP-IR in motoneurons associated with calcitonin gene-related peptide
9) Confidence 0.70 Published 1996 Journal J. Comp. Neurol. Section Abstract Doc Link 8742300 Disease Relevance 0.33 Pain Relevance 0.63
Calcitonin gene-related peptide (CGRP) causes headache and migraine in migraine patients, but CGRP receptor activation causes an increase in cyclic adenosine monophosphate (cAMP).
Positive_regulation (activation) of CGRP associated with adenocard, migraine, headache and calcitonin gene-related peptide
10) Confidence 0.70 Published 2006 Journal Cephalalgia Section Abstract Doc Link 17059437 Disease Relevance 0.91 Pain Relevance 1.11
Acute ischemic chest pain is not associated with increased calcitonin gene-related peptide (CGRP) levels in peripheral plasma nor in the coronary circulation.
Positive_regulation (increased) of CGRP in plasma associated with angina and calcitonin gene-related peptide
11) Confidence 0.70 Published 1999 Journal Scand. Cardiovasc. J. Section Title Doc Link 10540919 Disease Relevance 0.94 Pain Relevance 0.91
Acute ischemic chest pain is not associated with increased calcitonin gene-related peptide (CGRP) levels in peripheral plasma nor in the coronary circulation.
Positive_regulation (increased) of calcitonin gene-related peptide in plasma associated with angina and calcitonin gene-related peptide
12) Confidence 0.70 Published 1999 Journal Scand. Cardiovasc. J. Section Title Doc Link 10540919 Disease Relevance 0.94 Pain Relevance 0.91
A substantial elevation of the calcitonin gene-related peptide level in the external jugular but not the cubital fossa blood was seen in both classic and common migraine.
Positive_regulation (elevation) of calcitonin in external jugular associated with migraine, migraine without aura and calcitonin gene-related peptide
13) Confidence 0.70 Published 1990 Journal Ann. Neurol. Section Abstract Doc Link 1699472 Disease Relevance 0.81 Pain Relevance 1.10
A marked (119%) increase in calcitonin gene-related peptide was noted in the external jugular vein blood ipsilaterally during the flushing with no change in the other peptides measured.
Positive_regulation (increase) of calcitonin in blood associated with increased venous pressure under development and calcitonin gene-related peptide
14) Confidence 0.70 Published 1992 Journal Cephalalgia Section Abstract Doc Link 1559259 Disease Relevance 0.74 Pain Relevance 0.86
In 7 of 8 patients responding to subcutaneous sumatriptan administration, elevated CGRP levels (60 +/- 8 pmol/liter) were normalized, with the headache being relieved (40 +/- 8 pmol/liter).
Positive_regulation (elevated) of CGRP associated with sumatriptan, headache and calcitonin gene-related peptide
15) Confidence 0.70 Published 1993 Journal Ann. Neurol. Section Abstract Doc Link 8388188 Disease Relevance 0.48 Pain Relevance 0.98
Laboratory evaluation indicated elevated serum calcitonin and vasoactive intestinal polypeptide levels.
Positive_regulation (elevated) of calcitonin
16) Confidence 0.70 Published 2005 Journal Mayo Clin. Proc. Section Abstract Doc Link 15667039 Disease Relevance 1.42 Pain Relevance 0.08
This view is supported by the observation that jugular plasma levels of the potent vasodilator, calcitonin gene-related peptide (CGRP) are elevated during the headache and normalized by successful sumatriptan treatment.
Positive_regulation (elevated) of calcitonin gene-related peptide in plasma associated with sumatriptan, headache and calcitonin gene-related peptide
17) Confidence 0.70 Published 2001 Journal Microsc. Res. Tech. Section Abstract Doc Link 11301492 Disease Relevance 1.22 Pain Relevance 1.72
This view is supported by the observation that jugular plasma levels of the potent vasodilator, calcitonin gene-related peptide (CGRP) are elevated during the headache and normalized by successful sumatriptan treatment.
Positive_regulation (elevated) of CGRP in plasma associated with sumatriptan, headache and calcitonin gene-related peptide
18) Confidence 0.70 Published 2001 Journal Microsc. Res. Tech. Section Abstract Doc Link 11301492 Disease Relevance 1.16 Pain Relevance 1.65
These results suggest that CGRP, but not NO, released from non-adrenergic non-cholinergic nerves by electrical stimulation produces relaxation of canine lingual artery that is mediated by activation of CGRP1 receptors.
Positive_regulation (activation) of CGRP1 in nerves associated with calcitonin gene-related peptide
19) Confidence 0.70 Published 1995 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 7544421 Disease Relevance 0 Pain Relevance 0.47
It has been shown that calcitonin gene-related peptide (CGRP) is increased in blood taken from the external jugular vein (EJV) in humans during migraine and after stimulation of the trigeminal ganglion.
Positive_regulation (increased) of CGRP in EJV associated with ganglion cysts, trigeminal ganglion, migraine and calcitonin gene-related peptide
20) Confidence 0.70 Published 1993 Journal Cephalalgia Section Abstract Doc Link 8395344 Disease Relevance 1.03 Pain Relevance 0.87

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