INT48605

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Context Info
Confidence 0.49
First Reported 1994
Last Reported 2009
Negated 0
Speculated 2
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 1.26
Pain Relevance 2.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fos) nucleolus (Fos) nucleus (Fos)
DNA binding (Fos) transcription factor binding (Fos) response to stress (Fos)
Anatomy Link Frequency
brainstem 4
hypothalamus 2
neurons 2
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
withdrawal 6 99.42 Very High Very High Very High
cocaine 6 99.32 Very High Very High Very High
Opioid 1 99.20 Very High Very High Very High
Enkephalin 8 99.18 Very High Very High Very High
narcan 6 98.80 Very High Very High Very High
Serotonin 6 98.44 Very High Very High Very High
Hippocampus 1 98.44 Very High Very High Very High
Morphine 7 98.18 Very High Very High Very High
Thalamus 1 97.80 Very High Very High Very High
medulla 11 97.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 38 100.00 Very High Very High Very High
Opiate Addiction 1 99.42 Very High Very High Very High
Primary Sclerosing Cholangitis 19 86.56 High High
Urological Neuroanatomy 14 78.72 Quite High
Cognitive Disorder 2 75.00 Quite High
Stress 2 75.00 Quite High
Sleep Disorders 8 5.00 Very Low Very Low Very Low
Camurati-engelmann Disease 2 5.00 Very Low Very Low Very Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low
Vibrio Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with CTAP prevented the increase in c-Fos translation in each of these areas.
Positive_regulation (increase) of Localization (translation) of c-Fos
1) Confidence 0.49 Published 2009 Journal Neuroscience Section Abstract Doc Link 19422884 Disease Relevance 0.07 Pain Relevance 0.49
To reveal secretory, activational and transcriptional changes in the hypothalamus of morphine-dependent rats during naloxone precipitated opioid withdrawal, we measured corticosterone secretion, c-Fos induction and heteronuclear (hn)RNA levels of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) in naïve and morphine dependent animals injected with saline or 5 mg/kg naloxone.
Positive_regulation (induction) of Localization (secretion) of c-Fos in hypothalamus associated with narcan, withdrawal, opioid and morphine
2) Confidence 0.45 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17286593 Disease Relevance 0.17 Pain Relevance 1.00
Differences in the regional and cellular localization of c-fos messenger RNA induced by amphetamine, cocaine and caffeine in the rat.
Positive_regulation (induced) of Localization (localization) of c-fos messenger RNA associated with enkephalin and cocaine
3) Confidence 0.44 Published 1994 Journal Neuroscience Section Title Doc Link 7520134 Disease Relevance 0 Pain Relevance 0.57
Localization of the Fos/GAD double-stained neurons after PS recovery
Positive_regulation (stained) of Localization (Localization) of Fos/GAD in neurons associated with generalized anxiety disorder
4) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629845 Disease Relevance 0.85 Pain Relevance 0.20
Employing an immunocytochemical double-labeling technique, we investigated the co-localization of FOS protein, the expression product of c-fos proto-oncogene induced by orofacial noxious stimulation, and serotonin in the rat brainstem.
Positive_regulation (induced) of Spec (investigated) Localization (co-localization) of FOS in brainstem associated with medulla and serotonin
5) Confidence 0.37 Published 1998 Journal J Hirnforsch Section Abstract Doc Link 10022350 Disease Relevance 0.08 Pain Relevance 0.34
Employing an immunocytochemical double-labeling technique, we investigated the co-localization of FOS protein, the expression product of c-fos proto-oncogene induced by orofacial noxious stimulation, and serotonin in the rat brainstem.
Positive_regulation (induced) of Spec (investigated) Localization (co-localization) of fos in brainstem associated with medulla and serotonin
6) Confidence 0.32 Published 1998 Journal J Hirnforsch Section Abstract Doc Link 10022350 Disease Relevance 0.08 Pain Relevance 0.34

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