INT48615

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Context Info
Confidence 0.50
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.54
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1) extracellular space (IGF1) extracellular region (IGF1)
Anatomy Link Frequency
plasma 2
cartilage 2
extracellular matrix 2
molar 2
IGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
halothane 1 99.06 Very High Very High Very High
cytokine 9 72.32 Quite High
antagonist 1 54.44 Quite High
anesthesia 1 25.00 Low Low
Inflammation 37 17.56 Low Low
imagery 22 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
Osteoarthritis 7 5.00 Very Low Very Low Very Low
positron emission tomography 6 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 7 98.72 Very High Very High Very High
Hypoglycemia 1 95.56 Very High Very High Very High
Frailty 35 80.08 Quite High
Arthropathy 6 66.24 Quite High
Reprotox - General 1 2 65.32 Quite High
Renal Disease 5 48.08 Quite Low
Body Weight 2 42.52 Quite Low
Chronic Renal Failure 42 23.12 Low Low
INFLAMMATION 34 17.56 Low Low
Endometriosis (extended) 1 7.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With the appreciation that increased levels of IGF-1 binding proteins have been observed in osteoarthritic cartilage [57] one needs to consider if the optimal approach is to raise circulating IGF-1 levels or alternatively promote local production in an autocrine manner.
Positive_regulation (increased) of IGF-1 Binding (binding) of in cartilage associated with osteoarthritis
1) Confidence 0.50 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.16 Pain Relevance 0.06
The molar ratio for IGF-I/IGFBP-III was also calculated using the following equation:

(IGF-I/7·5)/(IGFBP-III/30·5)

Positive_regulation (calculated) of IGF-I Binding (ratio) of in molar
2) Confidence 0.41 Published 2007 Journal Clinical Endocrinology Section Body Doc Link PMC2366021 Disease Relevance 0 Pain Relevance 0
1, can be produced by chondrocytes and are accumulated in the extracellular matrix as a complex with binding proteins (IGF-I) or in a latent form (TGF-?
Positive_regulation (accumulated) of IGF-I Binding (complex) of in extracellular matrix
3) Confidence 0.38 Published 2007 Journal The Open Biomedical Engineering Journal Section Body Doc Link PMC2701085 Disease Relevance 0 Pain Relevance 0
By complexing IGF-1 to its primary circulating binding protein IGFBP-3, it is possible to significantly increase the IGF-1 dose while eliminating the side effect of hypoglycemia that occurs with IGF-1 alone [101].
Positive_regulation (complexing) of IGF-1 Binding (binding) of associated with hypoglycemia
4) Confidence 0.34 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2832869 Disease Relevance 0.38 Pain Relevance 0
Halothane anaesthesia in young sheep results in greatly increased plasma binding capacity for radiolabelled insulin-like growth factor (IGF), as demonstrated using size-exclusion chromatography.
Positive_regulation (increased) of insulin-like growth factor Binding (capacity) of in plasma associated with halothane
5) Confidence 0.14 Published 1994 Journal J. Endocrinol. Section Abstract Doc Link 7520930 Disease Relevance 0 Pain Relevance 0.05

General Comments

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