INT48616

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Context Info
Confidence 0.43
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 5.62
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGFBP1) extracellular space (IGFBP1) extracellular region (IGFBP1)
Anatomy Link Frequency
plasma 1
testis 1
liver 1
cartilage 1
legs 1
IGFBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 108 99.98 Very High Very High Very High
rheumatoid arthritis 462 98.52 Very High Very High Very High
Inflammatory marker 6 97.76 Very High Very High Very High
Neuropeptide 3 90.52 High High
Inflammation 92 89.40 High High
cINOD 11 85.88 High High
Pain 20 77.12 Quite High
tolerance 11 69.72 Quite High
halothane 1 61.72 Quite High
antagonist 27 54.44 Quite High
Disease Link Frequency Relevance Heat
Acromegaly 83 99.28 Very High Very High Very High
Osteoarthritis 9 98.72 Very High Very High Very High
Rheumatoid Arthritis 462 98.52 Very High Very High Very High
Critical Illness 9 98.52 Very High Very High Very High
Chronic Renal Failure 43 98.50 Very High Very High Very High
INFLAMMATION 104 97.76 Very High Very High Very High
Liver Disease 12 97.44 Very High Very High Very High
Obesity 99 96.74 Very High Very High Very High
Disorder Of Lipid Metabolism 24 85.60 High High
Body Weight 11 79.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The IGFBP-1 assay used matched antibody pairs (R&D, Abingdon, Oxford) and was conducted according to manufacturer's protocols.
Positive_regulation (conducted) of IGFBP-1
1) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
The elevation of plasma IGFBP-1 immunoreactivity was associated with reduced concentrations of glucose and insulin, the regulators of IGFBP-1 in humans and rats.
Positive_regulation (elevation) of IGFBP-1 in plasma
2) Confidence 0.29 Published 1994 Journal J. Endocrinol. Section Abstract Doc Link 7520930 Disease Relevance 0 Pain Relevance 0.03
IGFBP-1, which is also derived from the liver, binds to free IGF-I and is negatively regulated by nutrition and insulin [20].
Positive_regulation (derived) of IGFBP-1 in liver
3) Confidence 0.14 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206381 Disease Relevance 0.54 Pain Relevance 0.14
Elevated IGFBP-1 levels as observed in patients with RA could further reduce free IGF-I availability and action [21].
Positive_regulation (Elevated) of IGFBP-1 associated with rheumatoid arthritis
4) Confidence 0.14 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206381 Disease Relevance 0.51 Pain Relevance 0.15
Other sites of inhibition may include uterine epithelium (by inducing IGFBP-1 and lowering free IGF-I), Leydig cells in the testis, and granulosa-luteal cells in the ovary (by blocking steroidogenesis) [624, 628–633].
Positive_regulation (inducing) of IGFBP-1 in testis
5) Confidence 0.12 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.11 Pain Relevance 0.05
Similarly, cytokines upregulate IGFBP-1 synthesis [30].
Positive_regulation (upregulate) of IGFBP-1 associated with cytokine
6) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206381 Disease Relevance 1.02 Pain Relevance 0.32
Serum obtained at 8 a.m. after an overnight fast was used for measurements of IGF-I, IGFBP-1 and IGFBP-3, CRP, and IL-6.
Positive_regulation (measurements) of IGFBP-1
7) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206381 Disease Relevance 0.24 Pain Relevance 0.10
Of note is the recent report by Nemet and colleagues [31] demonstrating that short-term infusion of recombinant human IL-6 in healthy young men to levels typically occurring during exercise decreases serum concentrations of IGF-I and increases those of GH and IGFBP-1.
Positive_regulation (increases) of IGFBP-1
8) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206381 Disease Relevance 1.00 Pain Relevance 0.37
In general, patients with ESRD appear to exhibit normal or high concentrations of IGF-I and considerably elevated concentrations of IGFBP-I and IGFBP-III, which increase with declining renal function,13 demonstrating that the GH–IGF-I axis is affected on several levels.
Positive_regulation (elevated) of IGFBP-I associated with chronic renal failure
9) Confidence 0.10 Published 2007 Journal Clinical Endocrinology Section Body Doc Link PMC2366021 Disease Relevance 0.55 Pain Relevance 0
In this study, a well-characterized group of pre- and perimenopausal women with clinically and biochemically active RA, compared with age- and BMI-matched healthy women, exhibited reduced morning serum concentrations of IGF-I, a trend toward lower IGFBP-3, accelerated GH circulatory half-life, trends toward increases in IGFBP-1 and IL-6 levels (and total GH production), unaltered pulsatile, nycthemeral, or feedback-sensitive (entropic) features of cortisol or DHEA secretion, and substantially decreased LBM, especially in the legs.
Positive_regulation (increases) of IGFBP-1 in legs associated with obesity and rheumatoid arthritis
10) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206381 Disease Relevance 0.80 Pain Relevance 0.21
The binding constants for OTA and WAR decreased in the series D2z.Gt;D3>D1.
Positive_regulation (constants) of binding
11) Confidence 0.06 Published 2002 Journal Chem. Biol. Interact. Section Abstract Doc Link 12385724 Disease Relevance 0.09 Pain Relevance 0.09
The concentration of IGFBP3, the main IGF carrier protein, is usually increased in patients with acromegaly, but this marker offers little further diagnostic information.


Positive_regulation (increased) of IGF carrier protein associated with acromegaly
12) Confidence 0.03 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2459162 Disease Relevance 0.59 Pain Relevance 0.03
Due to the symmetry of the HOTSM, its concentration-binding curves are all mono-phasic increasing from 0 to 100%, with varying steepness, but without bell-shapes, terraces, or reverse ditto.
Neg (without) Positive_regulation (increasing) of binding
13) Confidence 0.01 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC493267 Disease Relevance 0 Pain Relevance 0
With the appreciation that increased levels of IGF-1 binding proteins have been observed in osteoarthritic cartilage [57] one needs to consider if the optimal approach is to raise circulating IGF-1 levels or alternatively promote local production in an autocrine manner.
Positive_regulation (increased) of binding in cartilage associated with osteoarthritis
14) Confidence 0.00 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.16 Pain Relevance 0.06

General Comments

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