INT48626

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Context Info
Confidence 0.66
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 33
Total Number 34
Disease Relevance 29.79
Pain Relevance 7.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Csf3) extracellular region (Csf3) enzyme binding (Csf3)
Anatomy Link Frequency
granulocyte 7
synovial fluid 2
hepatocytes 2
plasma 1
macrophages 1
Csf3 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 46 100.00 Very High Very High Very High
rheumatoid arthritis 114 99.96 Very High Very High Very High
cytokine 107 99.88 Very High Very High Very High
Arthritis 205 99.84 Very High Very High Very High
ischemia 23 98.60 Very High Very High Very High
Inflammation 213 98.52 Very High Very High Very High
Angina 1 98.36 Very High Very High Very High
Spinal cord 58 96.52 Very High Very High Very High
chemokine 25 95.12 Very High Very High Very High
Inflammatory mediators 8 94.84 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 116 99.96 Very High Very High Very High
Leukocytosis 5 99.90 Very High Very High Very High
Arthritis 222 99.84 Very High Very High Very High
Disorders Of Creatine Metabolism 10 99.58 Very High Very High Very High
Sleep Disorders 3 99.28 Very High Very High Very High
Disease 250 98.92 Very High Very High Very High
Fever 10 98.64 Very High Very High Very High
Cv Unclassified Under Development 11 98.60 Very High Very High Very High
Injury 158 98.58 Very High Very High Very High
INFLAMMATION 274 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The observation that the G-CSF receptor was induced by axotomy parallels findings from other neurological disease models, such as stroke, spinal cord injury, or ALS [6,7], and underlines the notion that the G-CSF system is part of an endogenous protective system for neurons.
Positive_regulation (induced) of G-CSF in neurons associated with neurological disease, stroke, motor neuron diseases and spinal cord
1) Confidence 0.66 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844381 Disease Relevance 0.83 Pain Relevance 0.09
Previous studies have reported on impaired induction of G-CSF in LPS-stimulated macrophages derived from mice expressing only the dominant-negative LIP form of c/ebp Beta (33).
Positive_regulation (induction) of G-CSF in macrophages
2) Confidence 0.59 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 1.42 Pain Relevance 0.44
We used transgenic mice harbouring a bidirectional tta-responsive construct with expression cassettes for murine G-CSF and EYFP (pBEG).
Positive_regulation (murine) of G-CSF associated with targeted disruption
3) Confidence 0.48 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844381 Disease Relevance 0.59 Pain Relevance 0.18
To generate the pBI-EYFP-G-CSF ("pBEG") plasmid, G-CSF was amplified from a mouse brain cDNA library and inserted into the pBI Tet vector (Clontech) using the restriction sites NheI and EcoRV.
Positive_regulation (inserted) of G-CSF in brain
4) Confidence 0.48 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844381 Disease Relevance 0.59 Pain Relevance 0.09
For generating CNS- target G-CSF overexpressing mice, mice of line BEG6 were crossed with mice expressing the Tet-transactivator under control of the CaMKII-promoter (CaMKII-tta) [33], and successful activation of the construct was verified by EYFP imaging.


Positive_regulation (generating) of G-CSF associated with central nervous system and imagery
5) Confidence 0.45 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844381 Disease Relevance 0.56 Pain Relevance 0.23
Thus, partial antagonism of endogenous G-CSF, as described in this study for LNA-antimiR-mediated G-CSF down-regulation, might provide a positive outcome for arthritis patients without increased risk of severe neutropenia.
Positive_regulation (mediated) of G-CSF associated with neutropenia and arthritis
6) Confidence 0.42 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 1.68 Pain Relevance 0.54
In donors who received G-CSF for 5 days, the absolute neutrophil count was increased after one G-CSF dose, and it reached a maximum on Day 6, as did the number of CD34+ cells (64.6 +/- 55.9 x 10(6) cells/L).
Positive_regulation (received) of G-CSF in neutrophil
7) Confidence 0.40 Published 1996 Journal Transfusion Section Body Doc Link 8701455 Disease Relevance 0 Pain Relevance 0
In patients with active rheumatoid arthritis, G-CSF is elevated in the serum and synovial fluid and correlates with disease severity (31).
Positive_regulation (elevated) of G-CSF in synovial fluid associated with rheumatoid arthritis and disease
8) Confidence 0.39 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 1.48 Pain Relevance 0.49
Acute lung Injury in a healthy donor during mobilization of peripheral blood stem cells using granulocyte-colony stimulating factor alone.
Positive_regulation (using) of granulocyte-colony stimulating factor in granulocyte associated with injury
9) Confidence 0.38 Published 2005 Journal Haematologica Section Title Doc Link 15753051 Disease Relevance 0.92 Pain Relevance 0.21
These factors include colony stimulating factors GM-CSF (Csf2) and G-CSF (Csf3); cytokines Ccl5, Cxcl1, Cxcl6 and Tslp; angiogenic factors Agpt2 and Vegfc; and acute phase proteins Saa3, C3, and Lcn2.
Positive_regulation (stimulating) of Csf3 associated with cytokine
10) Confidence 0.36 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 1.58 Pain Relevance 0.33
These factors include colony stimulating factors GM-CSF (Csf2) and G-CSF (Csf3); cytokines Ccl5, Cxcl1, Cxcl6 and Tslp; angiogenic factors Agpt2 and Vegfc; and acute phase proteins Saa3, C3, and Lcn2.
Positive_regulation (stimulating) of G-CSF associated with cytokine
11) Confidence 0.36 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 1.58 Pain Relevance 0.33
We detected significant plasma elevations of only IL-6, G-CSF, and MMP-3 at day 8 (peak disease) in the mouse CAIA model when compared with naïve animals (Figure 4b to 4d).
Positive_regulation (elevations) of G-CSF in plasma associated with disease and arthritis
12) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911895 Disease Relevance 0.67 Pain Relevance 0.35
No donor required a reduced or increased G-CSF dosage because of a high leukocyte count on the third day of mobilisation.
Positive_regulation (increased) of G-CSF in leukocyte
13) Confidence 0.35 Published 2010 Journal Transfusion Medicine (Oxford, England) Section Body Doc Link PMC2871169 Disease Relevance 0.68 Pain Relevance 0.09
Patients were given topical G-CSF for OU (4 x 120 microg/day, for 5 days) and/or GU (4 x 30 microg/day, for 5 days) and followed-up for 3 months after treatment.
Positive_regulation (followed-up) of G-CSF
14) Confidence 0.33 Published 2006 Journal J Eur Acad Dermatol Venereol Section Body Doc Link 16922940 Disease Relevance 0.33 Pain Relevance 0
Finally, Italian medical oncologists appear to be very cautious in introducing G-CSF when treating elderly patients.
Positive_regulation (introducing) of G-CSF
15) Confidence 0.32 Published 2005 Journal Oncol. Rep. Section Abstract Doc Link 16273232 Disease Relevance 0.87 Pain Relevance 0.07
They showed marked leukocytosis and elevation of serum G-CSF levels.
Positive_regulation (elevation) of G-CSF associated with leukocytosis
16) Confidence 0.27 Published 2009 Journal Hinyokika Kiyo Section Abstract Doc Link 19462829 Disease Relevance 1.11 Pain Relevance 0.10
A clinically attractive approach is to use granulocyte colony-stimulating factor (G-CSF) to mobilize HSCs to the circulation, and it has been reported that G-CSF administration after partial orthotopic liver transplantation greatly improved survival rate and liver regeneration of partial graft, partly by its mobilizing HSCs into the injured liver to differentiate into hepatocytes through hepatic oval cell engraftment.
Positive_regulation (use) of G-CSF in hepatocytes
17) Confidence 0.27 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2941114 Disease Relevance 0.43 Pain Relevance 0
A clinically attractive approach is to use granulocyte colony-stimulating factor (G-CSF) to mobilize HSCs to the circulation, and it has been reported that G-CSF administration after partial orthotopic liver transplantation greatly improved survival rate and liver regeneration of partial graft, partly by its mobilizing HSCs into the injured liver to differentiate into hepatocytes through hepatic oval cell engraftment.
Positive_regulation (use) of granulocyte colony-stimulating factor in hepatocytes
18) Confidence 0.27 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2941114 Disease Relevance 0.42 Pain Relevance 0
IL-6 and G-CSF biomarkers increased in CAIA and were significantly decreased by all treatments to a similar extent (Figures 4b, c).
Positive_regulation (increased) of G-CSF associated with arthritis
19) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911895 Disease Relevance 0.73 Pain Relevance 0.36
The laboratory examination showed remarkable leukocytosis of 79,700/mm3 in the peripheral blood and serum analysis revealed high value of granulocyte colony stimulating factor (G-CSF), 240 pg/ml (normal: less than 30 pg/ml).
Positive_regulation (value) of G-CSF in granulocyte associated with leukocytosis
20) Confidence 0.25 Published 1994 Journal Nippon Hinyokika Gakkai Zasshi Section Abstract Doc Link 7521443 Disease Relevance 1.26 Pain Relevance 0.17

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