INT48628

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.66
First Reported 1993
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.15
Pain Relevance 2.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 4
peripheral nerves 1
Tcrb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuritis 28 99.98 Very High Very High Very High
tolerance 8 95.72 Very High Very High Very High
Sciatic nerve 1 89.08 High High
Intracerebroventricular 3 76.20 Quite High
Pain 1 72.16 Quite High
agonist 1 68.24 Quite High
opioid receptor 1 67.52 Quite High
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 28 99.98 Very High Very High Very High
Disease 4 90.32 High High
Immunization 1 86.48 High High
Cancer 1 82.80 Quite High
Necrosis 1 82.32 Quite High
Multiple Sclerosis 4 76.20 Quite High
Pain 1 72.16 Quite High
Syndrome 2 69.16 Quite High
Demyelinating Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was more diverse than the MBP-68-88-specific response in which only a single Tcrb-V8 family member was used.
Gene_expression (used) of Tcrb-V8
1) Confidence 0.66 Published 1994 Journal Immunogenetics Section Abstract Doc Link 7521858 Disease Relevance 0.54 Pain Relevance 0.40
Thus, T-cell receptor beta chain usage in the response to this dominant neuritogenic peptide appears to be less restricted than the response to the dominant encephalitogenic determinant of MBP both in V region usage and in CDR3 usage.
Gene_expression (usage) of T-cell receptor beta chain in T-cell
2) Confidence 0.66 Published 1994 Journal Immunogenetics Section Abstract Doc Link 7521858 Disease Relevance 0.50 Pain Relevance 0.37
T-cell receptor V beta-element expression in peripheral nerves of Lewis rats suffering from experimental autoimmune neuritis.
Gene_expression (expression) of T-cell receptor V beta-element in peripheral nerves associated with experimental autoimmune neuritis and neuritis
3) Confidence 0.40 Published 1997 Journal J. Neuroimmunol. Section Title Doc Link 9357449 Disease Relevance 0.54 Pain Relevance 0.56
We showed previously that T cells involved in EAN utilize the T cell antigen receptor V beta 8, whereas less than 5% of normal rat peripheral T cells express V beta 8.
Gene_expression (express) of V beta 8 in T cells associated with neuritis
4) Confidence 0.20 Published 1993 Journal Cell. Immunol. Section Abstract Doc Link 7690307 Disease Relevance 0.68 Pain Relevance 0.61
We showed previously that T cells involved in EAN utilize the T cell antigen receptor V beta 8, whereas less than 5% of normal rat peripheral T cells express V beta 8.
Gene_expression (utilize) of V beta 8 in T cells associated with neuritis
5) Confidence 0.17 Published 1993 Journal Cell. Immunol. Section Abstract Doc Link 7690307 Disease Relevance 0.65 Pain Relevance 0.58
Additionally, SNC 80 did not significantly affect splenic T cell or natural killer cell populations as measured by the expression of T cell receptoralphabeta, and T helper (CD4), T suppressor/cytotoxic (CD8) and natural killer cell surface markers.
Gene_expression (expression) of cell receptoralphabeta in T cell
6) Confidence 0.02 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9694952 Disease Relevance 0.24 Pain Relevance 0.25

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox