INT4863

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Context Info
Confidence 0.37
First Reported 1992
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 22
Total Number 27
Disease Relevance 9.13
Pain Relevance 6.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
visceral 4
neurons 3
plasma 1
liver 1
bursa 1
ap (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 630 100.00 Very High Very High Very High
Rsd 18 99.62 Very High Very High Very High
dorsal root ganglion 108 99.36 Very High Very High Very High
Enkephalin 11 98.36 Very High Very High Very High
antagonist 14 97.24 Very High Very High Very High
adenocard 4 92.64 High High
Mechanotransduction 114 88.96 High High
Pain 29 79.56 Quite High
Inflammation 92 79.28 Quite High
palliative 4 74.76 Quite High
Disease Link Frequency Relevance Heat
Hypophosphatasia 96 100.00 Very High Very High Very High
Metastasis 16 99.96 Very High Very High Very High
Hypoalbuminemia 4 99.96 Very High Very High Very High
Disease 153 99.72 Very High Very High Very High
Reflex Sympathetic Dystrophy 18 99.62 Very High Very High Very High
Ganglion Cysts 114 99.36 Very High Very High Very High
Disease Progression 8 92.40 High High
Congenital Anomalies 16 88.04 High High
Death 14 86.40 High High
Dental Caries 4 86.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The unsedimentable activities of acid phosphatase (AP) and beta-glucosidase (BG), from mice liver lysosomes significantly increased 6 h after a single i/p injection of Met-enkephalin (MENK).
Positive_regulation (increased) of AP in liver associated with enkephalin
1) Confidence 0.37 Published 1993 Journal Biomed. Pharmacother. Section Abstract Doc Link 8329664 Disease Relevance 0 Pain Relevance 0.44
The random opening of sufficient numbers of Na channels can trigger a spontaneous AP which does not belong to any stimulus event (see Figure 1, circle H).
Positive_regulation (trigger) of AP associated with action potential
2) Confidence 0.18 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.69
To characterize these effects, we call the portion of the input stimulus that triggers an AP its stimulus event.
Positive_regulation (triggers) of AP associated with action potential
3) Confidence 0.18 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.60
MA-induced increases in activator protein (AP)-1 DNA binding activity, Fos-related antigen immunoreactivity (FRA-IR), proenkephalin mRNA expression, and proenkephalin-like immunoreactivity were reduced consistently in the striatum of animals that were pretreated with ginsenosides.
Positive_regulation (increases) of AP in striatum
4) Confidence 0.15 Published 2005 Journal Behav. Brain Res. Section Abstract Doc Link 15680202 Disease Relevance 0 Pain Relevance 0.30
In the acute stage of AD both OC level and AP activity were increased.
Positive_regulation (increased) of AP associated with rsd
5) Confidence 0.12 Published 1992 Journal Clin. Rheumatol. Section Abstract Doc Link 1281061 Disease Relevance 0.80 Pain Relevance 0.80
During the treatment, AP activity temporarily increased and then returned to the initial level.
Positive_regulation (increased) of AP
6) Confidence 0.10 Published 1992 Journal Clin. Rheumatol. Section Abstract Doc Link 1281061 Disease Relevance 0.77 Pain Relevance 0.77
Serum alkaline phosphatase (AP) activity is markedly reduced in hypophosphatasia, while urinary phosphoethanolamine (PEA) is increased.
Positive_regulation (increased) of AP associated with hypophosphatasia
7) Confidence 0.09 Published 2007 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2164941 Disease Relevance 1.27 Pain Relevance 0.14
Then, AP requirements may be less important and filled by the heterozygous cell, which may explain the improvement in adult patients.
Positive_regulation (requirements) of AP
8) Confidence 0.09 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2164941 Disease Relevance 0.62 Pain Relevance 0
Although glia cells and neurons were side-by-side on PDMS substrate (Fig. 2), when the indentation was displaced adjacent to glia cells, no AP was induced in neurite-free neurons in D2, D1+F, and D2+F groups.
Positive_regulation (induced) of AP in neurite associated with action potential
9) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2627935 Disease Relevance 0 Pain Relevance 0.15
We found that mechanical stimulation of neurites cultured on PDMS substrates that were coated with poly-L-lysine induced an AP in only 35% of DRG neurons (n?
Positive_regulation (induced) of AP in neurons associated with dorsal root ganglion and action potential
10) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2627935 Disease Relevance 0.24 Pain Relevance 0.35
While the actin/microtubule inhibitors effectively abolished the stretch-induced AP response in all neurite-bearing neurons, a washout of the drugs did not confer a reversible AP response to stretch (Fig. 5).
Positive_regulation (induced) of AP in neurons associated with action potential
11) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2627935 Disease Relevance 0.05 Pain Relevance 0.17
These results therefore confirmed that IxAC proteins are able to inhibit the activation of the AP on a surface by preventing deposition of C3b and Bb.


Positive_regulation (activation) of AP
12) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.20 Pain Relevance 0
We also tested the ability of IxACs to inhibit activation of the AP on agarose-coated ELISA plates using human serum as a source of complement factors.
Positive_regulation (activation) of AP
13) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
Furthermore, a lower threshold for the induction of an AP in these cultures was observed (213 vs. 160 ┬ÁN).
Positive_regulation (induction) of AP associated with action potential
14) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2627935 Disease Relevance 0.40 Pain Relevance 0.52
When an indented depth activated an AP response, we always applied the same indentation force again to determine whether the stretch-activated AP was repeatable.
Spec (whether) Positive_regulation (activated) of AP associated with action potential
15) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2627935 Disease Relevance 0 Pain Relevance 0.17
Indentation of the PDMS did not induce an AP in neurons without neurite outgrowth by day 2 (n?
Neg (not) Positive_regulation (induce) of AP in neurons associated with action potential
16) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2627935 Disease Relevance 0.30 Pain Relevance 0.38
The C2C12 cell line is an established detector of BMP type I receptor-related BMP activity owing to its induction of AP [9].
Positive_regulation (induction) of AP
17) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779385 Disease Relevance 0.21 Pain Relevance 0.07
In the univariate analyses, factors predictive of time to progression were visceral metastases, elevated alkaline phosphatase (AP) levels, performance status (PS), and elevated carcinoembryonic antigen (CEA) and CA 19-9 levels.
Positive_regulation (elevated) of AP in visceral associated with metastasis
18) Confidence 0.04 Published 2003 Journal Clin Colorectal Cancer Section Abstract Doc Link 12620142 Disease Relevance 0.76 Pain Relevance 0.07
The fact that inhibition of AP activity is only induced by some IxACs in only one bird and one reptile might seem surprising given the very wide specificity of I. ricinus.
Positive_regulation (induced) of AP
19) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
On the other hand, however, AP-specific inhibitors could not be restricted to diseases initiated by AP activation as, in many cases, the alternative pathway loop is triggered as a secondary effect to amplify the activation, irrespective of the initial trigger (AP, CP or lectin pathway).
Positive_regulation (activation) of AP associated with disease
20) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 1.11 Pain Relevance 0.13

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