INT48635

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Context Info
Confidence 0.49
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 15.38
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pts) lyase activity (Pts) cellular_component (Pts)
cytoplasm (Pts)
Anatomy Link Frequency
fibroblasts 1
Pts (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Tetrahydrobiopterin 14 100.00 Very High Very High Very High
cytokine 4 98.34 Very High Very High Very High
anesthesia 2 97.64 Very High Very High Very High
depression 7 97.56 Very High Very High Very High
headache 5 93.88 High High
Pain 7 93.68 High High
Neurotransmitter 2 80.96 Quite High
Dopamine 2 80.24 Quite High
Serotonin 2 79.72 Quite High
Lasting pain 7 76.00 Quite High
Disease Link Frequency Relevance Heat
Syndrome 64 100.00 Very High Very High Very High
Postthrombotic Syndrome 6 100.00 Very High Very High Very High
Thrombosis 63 99.92 Very High Very High Very High
Diabetes Mellitus 1 98.70 Very High Very High Very High
Depression 7 97.56 Very High Very High Very High
Anxiety Disorder 9 96.96 Very High Very High Very High
Tension-type Headache 4 93.88 High High
Pain 10 93.68 High High
Obesity 10 92.92 High High
Cv Unclassified Under Development 3 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVES: To determine the relative effectiveness of, and the rate of complications using non-pharmaceutical interventions in patients with DVT in the prevention of PTS.
Negative_regulation (prevention) of PTS
1) Confidence 0.49 Published 2004 Journal Cochrane Database Syst Rev Section Body Doc Link 14974060 Disease Relevance 0.09 Pain Relevance 0
Reducing patient weight might be an important strategy to prevent PTS.
Negative_regulation (prevent) of PTS associated with syndrome
2) Confidence 0.49 Published 2003 Journal Thromb. Haemost. Section Abstract Doc Link 12574811 Disease Relevance 1.76 Pain Relevance 0
Overall, in the treatment group at two years, the use of elastic compression stockings was associated with a highly statistically significant reduction in the incidence of PTS with odds ratio (OR) 0.31 (95% confidence interval (CI) 0.20 to 0.48).
Negative_regulation (reduction) of PTS
3) Confidence 0.36 Published 2004 Journal Cochrane Database Syst Rev Section Body Doc Link 14974060 Disease Relevance 0 Pain Relevance 0
In addition, the incidence of severe PTS was reduced from OR 0.39 (95% CI 0.20 to 0.76).
Negative_regulation (reduced) of PTS
4) Confidence 0.36 Published 2004 Journal Cochrane Database Syst Rev Section Body Doc Link 14974060 Disease Relevance 0 Pain Relevance 0
Prevention of recurrent thrombosis and use of compression elastic stockings are the cornerstones of PTS prevention.
Negative_regulation (prevention) of PTS associated with syndrome and thrombosis
5) Confidence 0.36 Published 2000 Journal Curr Opin Pulm Med Section Abstract Doc Link 10912643 Disease Relevance 1.25 Pain Relevance 0.06
Future research should focus on elucidating the pathophysiology and risk factors for PTS, assessing the safety and effectiveness of catheter-directed thrombolysis to prevent PTS and evaluating the optimal use of compression stockings to prevent and treat PTS.
Negative_regulation (prevent) of PTS associated with syndrome
6) Confidence 0.32 Published 2006 Journal Br. J. Haematol. Section Abstract Doc Link 16822286 Disease Relevance 1.61 Pain Relevance 0.07
Catheter-directed venous thrombolysis has been proposed as a means of reducing the risk of PTS, as this will actually dissolve the acute thrombus, restore venous patency, and, most importantly, restore venous valve function.
Negative_regulation (reducing) of PTS associated with postthrombotic syndrome and thrombosis
7) Confidence 0.32 Published 2009 Journal Tech Vasc Interv Radiol Section Abstract Doc Link 19853232 Disease Relevance 1.90 Pain Relevance 0.11
There is no proven role for thrombolysis of the initial DVT to prevent PTS.
Negative_regulation (prevent) of PTS associated with syndrome and thrombosis
8) Confidence 0.30 Published 2002 Journal Blood Rev. Section Abstract Doc Link 12163001 Disease Relevance 2.22 Pain Relevance 0.06
Tetrahydrobiopterin (BH4) deficiency, a variant form of hyperphenylalaninemia with progressive neurological dysfunction, is primarily caused by autosomal recessive mutations in the gene encoding the 6-pyruvoyl-tetrahydropterin synthase (PTPS).
Negative_regulation (deficiency) of Tetrahydrobiopterin associated with anesthesia and tetrahydrobiopterin
9) Confidence 0.30 Published 1996 Journal Hum. Gene Ther. Section Abstract Doc Link 8864759 Disease Relevance 0 Pain Relevance 0.40
Therefore, prevention of DVT is essential to reduce PTS, and thus improve outcomes and reduce overall healthcare costs.
Negative_regulation (reduce) of PTS associated with syndrome and thrombosis
10) Confidence 0.30 Published 2009 Journal J. Thromb. Thrombolysis Section Abstract Doc Link 19224134 Disease Relevance 1.90 Pain Relevance 0.08
Retrovirus-mediated gene transfer of 6-pyruvoyl-tetrahydropterin synthase corrects tetrahydrobiopterin deficiency in fibroblasts from hyperphenylalaninemic patients.
Negative_regulation (deficiency) of tetrahydrobiopterin in fibroblasts associated with tetrahydrobiopterin and cytokine
11) Confidence 0.26 Published 1996 Journal Hum. Gene Ther. Section Title Doc Link 8864759 Disease Relevance 0 Pain Relevance 0.55
The fp decreased even though iron-limited erythropoiesis also lowered the Hb F concentration in three of our Pts.
Negative_regulation (lowered) of Pts
12) Confidence 0.17 Published 1994 Journal Am. J. Hematol. Section Abstract Doc Link 7522396 Disease Relevance 0.62 Pain Relevance 0.09
A significant negative correlation of PTS and CTS was observed in EM patients.
Negative_regulation (correlation) of PTS
13) Confidence 0.15 Published 2004 Journal Pain Section Abstract Doc Link 15494185 Disease Relevance 1.75 Pain Relevance 0.82
It has been described in several animal models (Heyliger et al. 1985, Meyerovitch et al. 1987, Brichard et al. 1988) and also in diabetic patients (Cohen et al. 1995) to act as an insulin mimic via its inhibition of PTPs in the insulin signalling pathway (Zinker et al. 2002).
Negative_regulation (inhibition) of PTPs associated with diabetes mellitus
14) Confidence 0.11 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.69 Pain Relevance 0.03
Therefore, prevention of DVT is the only effective approach to PTS prevention.
Negative_regulation (prevention) of PTS associated with syndrome and thrombosis
15) Confidence 0.04 Published 2000 Journal Orthopedics Section Abstract Doc Link 10875426 Disease Relevance 1.60 Pain Relevance 0.14

General Comments

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