INT4864

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Context Info
Confidence 0.34
First Reported 1988
Last Reported 2010
Negated 6
Speculated 2
Reported most in Body
Documents 22
Total Number 26
Disease Relevance 10.80
Pain Relevance 5.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (BGLAP) extracellular region (BGLAP) cell adhesion (BGLAP)
Golgi apparatus (BGLAP) structural molecule activity (BGLAP) cytoplasm (BGLAP)
Anatomy Link Frequency
osteoblasts 2
granulocyte 1
thyroid 1
BGLAP (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 35 100.00 Very High Very High Very High
spinal inflammation 60 99.90 Very High Very High Very High
5HT 705 99.58 Very High Very High Very High
agonist 120 99.32 Very High Very High Very High
Rsd 9 99.12 Very High Very High Very High
cINOD 12 98.04 Very High Very High Very High
antagonist 37 97.36 Very High Very High Very High
antidepressant 95 94.60 High High
Dopamine 70 94.52 High High
Osteoarthritis 168 93.48 High High
Disease Link Frequency Relevance Heat
Hypercalcemia 100 99.96 Very High Very High Very High
Low Back Pain 63 99.90 Very High Very High Very High
Anxiety Disorder 445 99.42 Very High Very High Very High
Drug Dependence 2 99.40 Very High Very High Very High
Reflex Sympathetic Dystrophy 9 99.12 Very High Very High Very High
Respiratory Syncytial Virus 348 98.48 Very High Very High Very High
Growth Problems 4 97.92 Very High Very High Very High
INFLAMMATION 72 97.80 Very High Very High Very High
Pain 28 97.40 Very High Very High Very High
Osteoporosis 156 94.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LTB(4) dose-dependently inhibited AP activity in OA osteoblasts, while its effect on osteocalcin depended on endogenous LTB(4) levels in these cells.
Regulation (effect) of osteocalcin in osteoblasts
1) Confidence 0.34 Published 2002 Journal Arthritis Rheum. Section Body Doc Link 12124864 Disease Relevance 0 Pain Relevance 0
Changes in serum osteocalcin and bone-specific alkaline phosphatase are associated with bone pain in donors receiving granulocyte-colony-stimulating factor for peripheral blood stem and progenitor cell collection.
Regulation (Changes) of osteocalcin in granulocyte associated with pain
2) Confidence 0.26 Published 1999 Journal Transfusion Section Title Doc Link 10220269 Disease Relevance 0.10 Pain Relevance 0.28
Effect of zinc supplementation on growth hormone secretion, IGF-I, IGFBP-3, somatomedin generation, alkaline phosphatase, osteocalcin and growth in prepubertal children with idiopathic short stature.
Regulation (Effect) of osteocalcin associated with growth problems
3) Confidence 0.26 Published 2005 Journal J. Pediatr. Endocrinol. Metab. Section Title Doc Link 15679071 Disease Relevance 0.23 Pain Relevance 0.07
However, no significant differences in changes in the serum osteocalcin and 1CTP levels were observed between the two groups.
Regulation (changes) of serum osteocalcin
4) Confidence 0.25 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815806 Disease Relevance 1.71 Pain Relevance 0
Neither alkaline phosphatase nor osteocalcin was truly affected by CS or GS alone or together; this is true for both basal conditions and hormonal stimulation.
Neg (Neither) Regulation (affected) of osteocalcin
5) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.66 Pain Relevance 0.23
We first examined the effect of CS and GS on alkaline phosphatase and osteocalcin in order to evaluate whether these agents could alter the level of bone markers of terminally differentiated osteoblasts.
Spec (examined) Regulation (effect) of osteocalcin in osteoblasts
6) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.68 Pain Relevance 0.27
This model provides a mechanism to explain the regulation of OC formation and provides an explanation for the positive correlation between the CD16 surface expression and bone erosion activity shown in this study.
Regulation (regulation) of OC
7) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.11 Pain Relevance 0
The differences between patients with AS and controls for BALP and osteocalcin were not statistically significant.


Regulation (controls) of osteocalcin associated with spinal inflammation
8) Confidence 0.16 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615310 Disease Relevance 0.59 Pain Relevance 0.51
Japan might provide an opportunity to test the validity of the model systems used to predict river levels of OC during high drug usage and to examine the long term effect of high OC levels on sewage treatment efficiency and biofilms in real life situations.
Spec (examine) Regulation (effect) of OC associated with drug dependence
9) Confidence 0.16 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2592279 Disease Relevance 0.33 Pain Relevance 0
Selective effects of licofelone on AP and osteocalcin occur via its role on LTB(4) production.
Regulation (effects) of osteocalcin
10) Confidence 0.15 Published 2002 Journal Arthritis Rheum. Section Body Doc Link 12124864 Disease Relevance 0 Pain Relevance 0
The concentration of OC in river water on a given day is provided by the following equation:
Regulation (concentration) of OC
11) Confidence 0.15 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1797841 Disease Relevance 0 Pain Relevance 0
Administered orally at the dose of 0.3 mg/kg in OCD patients, ipsapirone had no influence on OC symptom intensity.
Neg (no) Regulation (influence) of OC associated with anxiety disorder
12) Confidence 0.14 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2416754 Disease Relevance 0.25 Pain Relevance 0.42
In those patients with serial OC measurements, changes in serum OC were already evident within the first month of therapy.
Regulation (changes) of OC
13) Confidence 0.13 Published 1988 Journal Clin. Rheumatol. Section Abstract Doc Link 3265902 Disease Relevance 0.44 Pain Relevance 0.35
Based on current available data, CD16 might be involved in the regulation of OC development through its ITAM.
Regulation (regulation) of OC
14) Confidence 0.12 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.61 Pain Relevance 0.31
Racemic dl-fenfluramine (60 mg os) had no effect on OC symptom severity (Hollander et al 1992; McBride et al 1992), and prolactin and cortisol responses were normal (Hollander et al 1992, 1993; McBride et al 1992).
Neg (no) Regulation (effect) of OC
15) Confidence 0.12 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2416754 Disease Relevance 0.23 Pain Relevance 0.35
Signalling pathways regulating osteocalcin were analyzed in the presence of gal-3.
Regulation (regulating) of osteocalcin
16) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1860078 Disease Relevance 0.44 Pain Relevance 0.04
This suggests that acute depletion in 5HT availability has no influence on OC symptoms.
Neg (no) Regulation (influence) of OC associated with 5ht
17) Confidence 0.10 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2416754 Disease Relevance 0.43 Pain Relevance 0.40
Regulation of the osteogenic promoter, osteocalcin, by glucocorticoids, vitamin D, and thyroid hormone, occurs through the same nuclear pathway as PPAR?
Regulation (Regulation) of osteocalcin in thyroid
18) Confidence 0.10 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 0.26 Pain Relevance 0.03
As highlighted in Figure 3A, OC concentrations in the Lee catchment (R0 = 2.0) exceed 95 nM for nearly 1 week.
Regulation (concentrations) of OC
19) Confidence 0.09 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1797841 Disease Relevance 0.06 Pain Relevance 0
Influence of calcitonin treatment on the osteocalcin concentration in the algodystrophy of bone.
Regulation (Influence) of osteocalcin associated with rsd
20) Confidence 0.07 Published 1992 Journal Clin. Rheumatol. Section Title Doc Link 1281061 Disease Relevance 0.78 Pain Relevance 0.78

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