INT48642

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Context Info
Confidence 0.70
First Reported 1993
Last Reported 2010
Negated 3
Speculated 6
Reported most in Abstract
Documents 92
Total Number 99
Disease Relevance 24.59
Pain Relevance 53.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TCEA1) nucleolus (TCEA1) nucleus (TCEA1)
DNA binding (TCEA1)
Anatomy Link Frequency
SII 12
nucleus 6
anterior 4
insular cortex 3
cortex 3
TCEA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
primary somatosensory cortex 451 100.00 Very High Very High Very High
Somatosensory cortex 239 100.00 Very High Very High Very High
insula 79 100.00 Very High Very High Very High
Thalamus 66 100.00 Very High Very High Very High
Anterior cingulate cortex 61 100.00 Very High Very High Very High
Central grey 20 100.00 Very High Very High Very High
Pain 569 99.98 Very High Very High Very High
fifth nerve 23 99.98 Very High Very High Very High
electroacupuncture 48 99.84 Very High Very High Very High
nMDA receptor 2 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 46 100.00 Very High Very High Very High
Pain 415 99.98 Very High Very High Very High
Brain Injury 72 99.98 Very High Very High Very High
Nociception 44 99.84 Very High Very High Very High
Headache 45 98.84 Very High Very High Very High
Shock 11 98.44 Very High Very High Very High
Epilepsy 6 98.28 Very High Very High Very High
Nervous System Injury 1 96.40 Very High Very High Very High
Complex Regional Pain Syndromes 12 95.04 Very High Very High Very High
Cognitive Disorder 15 94.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, further increase of attention from mid-level to high was not accompanied by an additional enhancement of SII activity.
Positive_regulation (enhancement) of SII in SII associated with somatosensory cortex
1) Confidence 0.70 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12123852 Disease Relevance 0.32 Pain Relevance 0.81
Though pain stimuli followed the same intensity pattern in all paradigms, evoked SII activity increased markedly from the low attention task to the mid-level attention task (P < 0.001).
Positive_regulation (increased) of SII in SII associated with somatosensory cortex and pain
2) Confidence 0.70 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12123852 Disease Relevance 0.34 Pain Relevance 0.83
Capsaicin pain, which had no concomitant tactile component, produced little or no activation in secondary somatosensory cortex (SII), whereas light brushing produced a prominent activation of SII, suggesting a differential sensitivity of SII to tactile versus painful stimuli.
Positive_regulation (activation) of SII in SII associated with somatosensory cortex, pain and qutenza
3) Confidence 0.70 Published 1998 Journal Brain Section Abstract Doc Link 9619195 Disease Relevance 1.22 Pain Relevance 2.43
From our findings we suggest that parallel activation of SI and SII contralateral to the stimulation represents the first step in the cortical processing of C-fiber-related activities, probably related to second pain.
Positive_regulation (activation) of SII associated with pain, c fibre and primary somatosensory cortex
4) Confidence 0.70 Published 2002 Journal Neuroscience Section Abstract Doc Link 12127094 Disease Relevance 0.28 Pain Relevance 0.91
Thus far, the results suggest that the anterior and posterior regions of SII are differentially activated by contralateral, ipsilateral and bilateral stimulation.
Positive_regulation (activated) of SII in posterior regions
5) Confidence 0.69 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC552304 Disease Relevance 0 Pain Relevance 0
Likewise, suggestions that SII activation is predominantly related to processing the nociceptive quality of the stimulus (60,61) are inconsistent with many studies in both human and nonhuman subjects, which show a strong functional relationship between SII activity and innocuous (especially, vibrotactile) stimulation.
Positive_regulation (activation) of SII associated with nociception
6) Confidence 0.69 Published 2003 Journal Adv Neurol Section Abstract Doc Link 12894402 Disease Relevance 0.85 Pain Relevance 0.80
Additionally, we found an activation of the contra- and ipsilateral SII areas (peak latencies 304+/-22.7 and 310.1+/-19.4ms, respectively) and a variable activation of the cingulate cortex.
Positive_regulation (activation) of SII in cingulate cortex
7) Confidence 0.61 Published 2002 Journal Pain Section Abstract Doc Link 12467999 Disease Relevance 0 Pain Relevance 0.32
A direct comparison of pain and vibrotactile stimulation revealed that both stimuli produced activation in similar regions of SI and SII, regions long thought to be involved in basic somatosensory processing.
Positive_regulation (activation) of SII associated with pain
8) Confidence 0.61 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 8027764 Disease Relevance 0.52 Pain Relevance 0.88
These results suggest that fluvoxamine specifically reduced activation of the ACC and SII, which are areas concerned with the affective and integrative components of pain.
Positive_regulation (activation) of SII in ACC associated with pain, somatosensory cortex and anterior cingulate cortex
9) Confidence 0.61 Published 2003 Journal Neuroreport Section Abstract Doc Link 12858034 Disease Relevance 0.48 Pain Relevance 0.92
First, the hand and face stimulation activated SI and SII in the contralateral, but not in the ipsilateral, hemisphere.
Neg (not) Positive_regulation (activated) of SII in face
10) Confidence 0.61 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10594672 Disease Relevance 0 Pain Relevance 0.07
For lip stimulation SI and SII activations were reduced in patients with TN on the contra- but not on the ipsilateral side to the stimulus.
Positive_regulation (activations) of SII in lip associated with trigeminal neuralgia
11) Confidence 0.60 Published 2009 Journal Hum Brain Mapp Section Abstract Doc Link 19365802 Disease Relevance 0.92 Pain Relevance 1.09
We found that SI and SII activations in patients did neither depend on the affected side of TN nor differ between operated and nonoperated patients.
Positive_regulation (activations) of SII associated with trigeminal neuralgia
12) Confidence 0.60 Published 2009 Journal Hum Brain Mapp Section Abstract Doc Link 19365802 Disease Relevance 1.14 Pain Relevance 1.26
Briefly summarized, a localized increase in absorbance in both SI and SII was evoked by contralateral and also by bilateral flutter stimulation.
Positive_regulation (increase) of SII
13) Confidence 0.60 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1087848 Disease Relevance 0.12 Pain Relevance 0.05
Ipsilateral flutter stimulation also evoked a localized increase in absorbance in SII, but only a weak or negligible increase in the forepaw region of SI.
Positive_regulation (increase) of SII
14) Confidence 0.60 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1087848 Disease Relevance 0.20 Pain Relevance 0.04
Furthermore, fMRI activation in SII did not differ across the different levels of stimulus intensity (nonpainful, painful) and attention (non-counting, counting).
Positive_regulation (activation) of SII in SII associated with pain and somatosensory cortex
15) Confidence 0.58 Published 2008 Journal Neuroimage Section Abstract Doc Link 18329293 Disease Relevance 0 Pain Relevance 0.98
In this fMRI study we investigated the effect of attention on the activation of SI and SII, as induced by nonpainful and painful rare deviant electric stimuli during somatosensory oddball tasks.
Spec (investigated) Positive_regulation (activation) of SII in SII associated with pain, somatosensory cortex and primary somatosensory cortex
16) Confidence 0.58 Published 2008 Journal Neuroimage Section Abstract Doc Link 18329293 Disease Relevance 0 Pain Relevance 0.67
When considered as a single region, SII was more strongly activated in the contralateral than in the ipsilateral hemisphere.
Positive_regulation (activated) of SII
17) Confidence 0.57 Published 2003 Journal Neuroimage Section Abstract Doc Link 14642473 Disease Relevance 0.09 Pain Relevance 0.36
The nociceptive responses of ILN neurons were attenuated by stimulating SII.
Positive_regulation (stimulating) of SII in neurons associated with nociception
18) Confidence 0.51 Published 1994 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 7750169 Disease Relevance 0.27 Pain Relevance 0
[Influence of cooling motor cortex on the inhibitory effect of stimulation of SII on nociceptive responses in ILN neurons].
Positive_regulation (stimulation) of SII in neurons associated with nociception and nociceptor
19) Confidence 0.51 Published 1994 Journal Zhen Ci Yan Jiu Section Title Doc Link 7750169 Disease Relevance 0.25 Pain Relevance 0.10
Regions of the somatosensory cortex, including SI and part of SII in the mid-insula, were activated more by the neutral touch than by the pleasant and painful stimuli.
Positive_regulation (activated) of SII in cortex associated with pain, somatosensory cortex and insula
20) Confidence 0.50 Published 2003 Journal Cereb. Cortex Section Abstract Doc Link 12571120 Disease Relevance 0.24 Pain Relevance 1.39

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