INT48651

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Context Info
Confidence 0.61
First Reported 1994
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 2.95
Pain Relevance 2.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (GAL) Golgi apparatus (GAL) cellular_component (GAL)
response to stress (GAL) cytoplasm (GAL)
Anatomy Link Frequency
peripheral nerve 2
forebrain 2
GAL (Homo sapiens)
Pain Link Frequency Relevance Heat
dorsal root ganglion 4 100.00 Very High Very High Very High
Spinal cord 2 100.00 Very High Very High Very High
Enkephalin 1 100.00 Very High Very High Very High
antidepressant 3 99.98 Very High Very High Very High
Dynorphin 1 99.92 Very High Very High Very High
Cholecystokinin 1 99.36 Very High Very High Very High
Inflammation 5 99.16 Very High Very High Very High
Neurotransmitter 9 99.00 Very High Very High Very High
Peripheral nerve injury 3 98.48 Very High Very High Very High
Neuropeptide 28 96.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 4 100.00 Very High Very High Very High
INFLAMMATION 5 99.16 Very High Very High Very High
Anxiety Disorder 8 98.40 Very High Very High Very High
Nervous System Injury 5 98.04 Very High Very High Very High
Pain 10 96.92 Very High Very High Very High
Depression 7 94.48 High High
Stress 3 92.76 High High
Skin Cancer 1 90.44 High High
Neurodegenerative Disease 4 78.16 Quite High
Disease 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest the novel possibility that GALN1R gene expression may be regulated as a consequence of inflammatory conditions.
Regulation (regulated) of Gene_expression (expression) of GALN1R associated with inflammation
1) Confidence 0.61 Published 1997 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9425310 Disease Relevance 0.25 Pain Relevance 0.11
Neuronal activity regulates expression of phenotype-specific genes, including galanin, which coexists with choline acetyltransferase in septal and basal forebrain neurons.
Regulation (regulates) of Gene_expression (expression) of galanin in forebrain
2) Confidence 0.60 Published 1994 Journal Exp. Neurol. Section Abstract Doc Link 7523176 Disease Relevance 0 Pain Relevance 0.11
Changes in the expression of enkephalin, galanin, dynorphin and cholecystokinin mRNA in response to restraint and formalin-induced pain are documented in hypothalamic and amygdaloid nuclei by in situ hybridization histochemical technique.
Regulation (Changes) of Gene_expression (expression) of galanin associated with pain, dynorphin, enkephalin and cholecystokinin
3) Confidence 0.44 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11033323 Disease Relevance 0.36 Pain Relevance 0.47
Treatment with clinically efficacious antidepressants alters galanin and galanin receptor gene expression in rodents.
Regulation (alters) of Gene_expression (expression) of galanin associated with antidepressant
4) Confidence 0.40 Published 2006 Journal Amino Acids Section Abstract Doc Link 16733616 Disease Relevance 0.94 Pain Relevance 0.53
This finding suggests that in the septohippocampal cholinergic system perturbance of electrical activity alone can lead to temporary up-regulation of galanin expression, previously attributed exclusively to a "lesion effect."
Regulation (regulation) of Gene_expression (expression) of galanin
5) Confidence 0.26 Published 1994 Journal Exp. Neurol. Section Abstract Doc Link 7523176 Disease Relevance 0 Pain Relevance 0.12
Expression of galanin or galanin receptors in the DRG and spinal cord are altered, sometimes in a dramatic fashion, by peripheral nerve injury or inflammation.
Regulation (altered) of Gene_expression (Expression) of galanin in peripheral nerve associated with dorsal root ganglion, nervous system injury, inflammation, peripheral nerve injury and spinal cord
6) Confidence 0.26 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9928184 Disease Relevance 0.77 Pain Relevance 0.51
So far information is limited, but it has been demonstrated that galanin is expressed in DRGs and possibly also regulated.
Spec (possibly) Regulation (regulated) of Gene_expression (expressed) of galanin
7) Confidence 0.21 Published 2005 Journal Neuropeptides Section Abstract Doc Link 15893817 Disease Relevance 0.42 Pain Relevance 0.37
The presence of galanin could modulate the action of classical neurotransmitters like
Regulation (modulate) of Gene_expression (presence) of galanin associated with neurotransmitter
8) Confidence 0.19 Published 2007 Journal Bioinformation Section Body Doc Link PMC2248450 Disease Relevance 0.20 Pain Relevance 0.41
The hypothetical docking studies on the theoretical model of N-gal with three types galanin receptors of was performed to explore the importance of galanin residues
Regulation (importance) of Gene_expression (residues) of galanin
9) Confidence 0.16 Published 2007 Journal Bioinformation Section Body Doc Link PMC2248450 Disease Relevance 0 Pain Relevance 0

General Comments

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