INT48654

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Context Info
Confidence 0.42
First Reported 1994
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.14
Pain Relevance 2.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (GAL) Golgi apparatus (GAL) cellular_component (GAL)
response to stress (GAL) cytoplasm (GAL)
Anatomy Link Frequency
neurons 4
GAL (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 21 100.00 Very High Very High Very High
Eae 8 100.00 Very High Very High Very High
Enkephalin 1 100.00 Very High Very High Very High
orphanin 1 100.00 Very High Very High Very High
Dynorphin 2 99.96 Very High Very High Very High
intrathecal 1 98.22 Very High Very High Very High
Neurotransmitter 5 98.08 Very High Very High Very High
dorsal rhizotomy 1 97.72 Very High Very High Very High
Nerve growth factor 8 90.88 High High
Dorsal horn 3 88.72 High High
Disease Link Frequency Relevance Heat
Injury 11 100.00 Very High Very High Very High
Frailty 3 99.62 Very High Very High Very High
Wallerian Degeneration 1 96.32 Very High Very High Very High
Nociception 5 88.56 High High
Ganglion Cysts 4 77.56 Quite High
Pain 6 75.00 Quite High
Neuropathic Pain 1 75.00 Quite High
Hyperalgesia 1 59.32 Quite High
Intractable Pain 2 53.44 Quite High
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Selective up-regulation of neuropeptide synthesis by blocking the neuronal activity: galanin expression in septohippocampal neurons.
Negative_regulation (blocking) of Gene_expression (expression) of galanin in neurons associated with neuropeptide
1) Confidence 0.42 Published 1994 Journal Exp. Neurol. Section Title Doc Link 7523176 Disease Relevance 0 Pain Relevance 0.18
Transganglionic degenerative atrophy is accompanied by depletion of marker neuropeptides and enzymes, and later by the expression of vicarious neuropeptides such as vasoactive intestinal polypeptide, neuropeptide Y and galanin and of the enzyme choline acetyl transferase.
Negative_regulation (depletion) of Gene_expression (expression) of galanin associated with frailty and neuropeptide
2) Confidence 0.41 Published 2003 Journal Ann. Anat. Section Abstract Doc Link 12924468 Disease Relevance 0.99 Pain Relevance 0.79
We demonstrate here that dynorphin, galanin, NPY, nociceptin and enkephalin expression depends on Ptf1a, indicating that these neuropeptides are expressed in inhibitory neurons.
Negative_regulation (depends) of Gene_expression (expression) of galanin in neurons associated with dynorphin, orphanin, neuropeptide and enkephalin
3) Confidence 0.41 Published 2008 Journal Dev. Biol. Section Abstract Doc Link 18721803 Disease Relevance 0.07 Pain Relevance 0.68
Interaction of N-gal with three galanin receptors
Negative_regulation (three) of Gene_expression (receptors) of galanin
4) Confidence 0.18 Published 2007 Journal Bioinformation Section Body Doc Link PMC2248450 Disease Relevance 0 Pain Relevance 0
Intrathecal infusion of NT-3 globally mitigated both the increased incidence and elevated levels of galanin messenger RNA (mRNA) expression observed following CCI, reducing the former from 60% to 39%.
Negative_regulation (reducing) of Gene_expression (expression) of galanin messenger RNA associated with eae and intrathecal
5) Confidence 0.00 Published 2006 Journal Neuroscience Section Abstract Doc Link 16843605 Disease Relevance 1.07 Pain Relevance 0.91

General Comments

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