INT48656

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Context Info
Confidence 0.69
First Reported 1994
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.93
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd44) Golgi apparatus (Cd44) plasma membrane (Cd44)
nucleus (Cd44) protein complex (Cd44) cytoplasm (Cd44)
Cd44 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 5 76.16 Quite High
peptic ulcer disease 3 68.00 Quite High
cytokine 9 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stomach Cancer 2 99.84 Very High Very High Very High
Breast Cancer 7 99.48 Very High Very High Very High
Apoptosis 34 98.36 Very High Very High Very High
Cancer 823 97.80 Very High Very High Very High
Skin Cancer 10 97.80 Very High Very High Very High
Carcinoma 8 95.12 Very High Very High Very High
Residual Neoplasm 40 91.40 High High
Colorectal Cancer 128 89.08 High High
Metastasis 17 86.32 High High
Brain Tumor 60 85.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A key consequence of CD44 overexpression in gastric carcinomas may be development of the invasive phenotype and strong expression may indicate a poorer prognosis.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CD44 associated with stomach cancer
1) Confidence 0.69 Published 1994 Journal Hum. Pathol. Section Abstract Doc Link 7523275 Disease Relevance 1.58 Pain Relevance 0.17
Overexpression of CD44 on the other hand blocked p53-dependent apoptosis, leading to expansion of tumor-initiating cells [93].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of CD44 associated with cancer and apoptosis
2) Confidence 0.33 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.01 Pain Relevance 0.04
When tumorigenicity of CD44+ versus CD44?
Positive_regulation (versus) of Gene_expression (versus) of CD44
3) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.55 Pain Relevance 0
When tumorigenicity of CD44+ versus CD44?
Positive_regulation (When) of Gene_expression (versus) of CD44
4) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.56 Pain Relevance 0
When tumorigenicity of CD44+ versus CD44?
Positive_regulation (versus) of Gene_expression (versus) of CD44
5) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.55 Pain Relevance 0
When tumorigenicity of CD44+ versus CD44?
Positive_regulation (When) of Gene_expression (versus) of CD44
6) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.56 Pain Relevance 0
USC-HN1 cells demonstrate strong, uniform nuclear p53 and Rb expression, as well as positive expression of keratin, E-cadherin, EGFr, and CD44 in situ consistent with HNSCC as well as the original tumor biopsy [4,7,13,19].
Positive_regulation (nuclear) of Gene_expression (expression) of CD44 associated with cancer
7) Confidence 0.21 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 1.13 Pain Relevance 0

General Comments

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