INT48661

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.07
First Reported 1994
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.15
Pain Relevance 4.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA binding (Ddx5) nucleolus (Ddx5) nucleus (Ddx5)
enzyme binding (Ddx5)
Anatomy Link Frequency
striatum 3
neurons 1
Ddx5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 24 100.00 Very High Very High Very High
Somatostatin 2 99.92 Very High Very High Very High
Enkephalin 36 99.70 Very High Very High Very High
Lamotrigine 4 98.08 Very High Very High Very High
Glutamate 4 97.46 Very High Very High Very High
nMDA receptor 4 97.20 Very High Very High Very High
Nucleus accumbens 1 92.88 High High
narcan 4 91.92 High High
Neuropeptide 7 86.40 High High
nMDA receptor antagonist 2 83.24 Quite High
Disease Link Frequency Relevance Heat
Toxicity 2 75.00 Quite High
Parkinson's Disease 2 5.00 Very Low Very Low Very Low
Drug Dependence 1 5.00 Very Low Very Low Very Low
Psychosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to the decrease in enkephalin and substance P mRNA expression, somatostatin mRNA-expressing neurons were largely preserved.
Gene_expression (expression) of P mRNA in neurons associated with somatostatin, enkephalin and substance p
1) Confidence 0.07 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 7523600 Disease Relevance 0.07 Pain Relevance 0.37
Enkephalin and substance P mRNA expression in the striatum showed dose-dependent decreases following administration of 3-NP.
Gene_expression (expression) of P mRNA in striatum associated with enkephalin and substance p
2) Confidence 0.06 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 7523600 Disease Relevance 0.07 Pain Relevance 0.33
Both enkephalin mRNA and substance P mRNA expression in the rat striatum appear tonically stimulated through postsynaptic NMDA receptor mediated mechanisms.
Gene_expression (expression) of P mRNA in striatum associated with nmda receptor, enkephalin and substance p
3) Confidence 0.04 Published 1995 Journal J Neural Transm Park Dis Dement Sect Section Abstract Doc Link 9620062 Disease Relevance 0 Pain Relevance 0.91
Following subchronic administration of the presumed glutamate release inhibitor, lamotrigine (5 and 20mg/kg IP) there was no significant alterations in either enkephalin mRNA or substance P mRNA levels in the striatum.
Gene_expression (levels) of P mRNA in striatum associated with glutamate, lamotrigine, enkephalin and substance p
4) Confidence 0.03 Published 1995 Journal J Neural Transm Park Dis Dement Sect Section Abstract Doc Link 9620062 Disease Relevance 0 Pain Relevance 0.93
In contrast, it suppressed the increase in prodynorphin and substance P mRNA expression induced by methamphetamine.
Gene_expression (expression) of P mRNA associated with substance p
5) Confidence 0.02 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12542667 Disease Relevance 0 Pain Relevance 0.62
As reported previously, the unilateral dopaminergic lesion induced a significant and homogeneous decrease in striatal substance P mRNA expression and a marked increase in enkephalin mRNA expression in the ipsilateral neostriatum which was more pronounced in the dorsolateral than ventromedial part of the structure.
Gene_expression (expression) of P mRNA associated with enkephalin and substance p
6) Confidence 0.02 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221930 Disease Relevance 0 Pain Relevance 0.38
The chronic L-DOPA treatment in 6-hydroxydopamine-lesioned rats was found to partially reverse the lesion-induced down-regulation of substance P mRNA expression, without significantly affect the up-regulation of enkephalin when considering the neostriatum as a whole.
Gene_expression (expression) of P mRNA associated with enkephalin and substance p
7) Confidence 0.02 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221930 Disease Relevance 0 Pain Relevance 0.51

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox