INT48662

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Context Info
Confidence 0.04
First Reported 1994
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.07
Pain Relevance 2.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA binding (Ddx5) nucleolus (Ddx5) nucleus (Ddx5)
enzyme binding (Ddx5)
Anatomy Link Frequency
neurons 2
Ddx5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 25 100.00 Very High Very High Very High
substance P 16 100.00 Very High Very High Very High
Somatostatin 1 99.92 Very High Very High Very High
Nucleus accumbens 1 95.04 Very High Very High Very High
narcan 2 91.92 High High
Neuropeptide 7 88.56 High High
agonist 3 80.12 Quite High
antagonist 2 77.32 Quite High
Dopamine 1 72.32 Quite High
projection neuron 1 67.84 Quite High
Disease Link Frequency Relevance Heat
Toxicity 1 75.00 Quite High
Parkinson's Disease 3 5.00 Very Low Very Low Very Low
Drug Dependence 1 5.00 Very Low Very Low Very Low
Psychosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to the decrease in enkephalin and substance P mRNA expression, somatostatin mRNA-expressing neurons were largely preserved.
Negative_regulation (decrease) of Gene_expression (expression) of P mRNA in neurons associated with somatostatin, enkephalin and substance p
1) Confidence 0.04 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 7523600 Disease Relevance 0.07 Pain Relevance 0.38
As reported previously, the unilateral dopaminergic lesion induced a significant and homogeneous decrease in striatal substance P mRNA expression and a marked increase in enkephalin mRNA expression in the ipsilateral neostriatum which was more pronounced in the dorsolateral than ventromedial part of the structure.
Negative_regulation (decrease) of Gene_expression (expression) of P mRNA associated with enkephalin and substance p
2) Confidence 0.02 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221930 Disease Relevance 0 Pain Relevance 0.38
In contrast, it suppressed the increase in prodynorphin and substance P mRNA expression induced by methamphetamine.
Negative_regulation (suppressed) of Gene_expression (expression) of P mRNA associated with substance p
3) Confidence 0.01 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12542667 Disease Relevance 0 Pain Relevance 0.62
The chronic L-DOPA treatment in 6-hydroxydopamine-lesioned rats was found to partially reverse the lesion-induced down-regulation of substance P mRNA expression, without significantly affect the up-regulation of enkephalin when considering the neostriatum as a whole.
Negative_regulation (reverse) of Gene_expression (expression) of P mRNA associated with enkephalin and substance p
4) Confidence 0.01 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221930 Disease Relevance 0 Pain Relevance 0.51
The chronic L-DOPA treatment in 6-hydroxydopamine-lesioned rats was found to partially reverse the lesion-induced down-regulation of substance P mRNA expression, without significantly affect the up-regulation of enkephalin when considering the neostriatum as a whole.
Negative_regulation (regulation) of Gene_expression (expression) of P mRNA associated with enkephalin and substance p
5) Confidence 0.01 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221930 Disease Relevance 0 Pain Relevance 0.51

General Comments

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