INT48663

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Context Info
Confidence 0.59
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 45
Total Number 45
Disease Relevance 18.34
Pain Relevance 19.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Gfap) extracellular matrix organization (Gfap) cytoplasm (Gfap)
Anatomy Link Frequency
astrocytes 8
Notch 4
Spinal cord 4
occipital cortex 4
paw 4
Gfap (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spinal dorsal horn 19 100.00 Very High Very High Very High
ketamine 229 99.98 Very High Very High Very High
agonist 133 99.98 Very High Very High Very High
intrathecal 153 99.80 Very High Very High Very High
IPN 3 99.42 Very High Very High Very High
antagonist 254 99.20 Very High Very High Very High
Spinal nerve ligature 192 98.92 Very High Very High Very High
Glutamate 76 98.84 Very High Very High Very High
allodynia 345 98.36 Very High Very High Very High
Cannabinoid receptor 195 97.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypersensitivity 224 100.00 Very High Very High Very High
Necrosis 4 99.52 Very High Very High Very High
Neuropathic Pain 558 98.36 Very High Very High Very High
Hyperalgesia 21 96.28 Very High Very High Very High
Disease 178 96.00 Very High Very High Very High
Hydrocephalus 372 95.68 Very High Very High Very High
Hypoxia 41 95.20 Very High Very High Very High
Inflammatory Pain 12 95.16 Very High Very High Very High
Injury 304 94.72 High High
Cv Unclassified Under Development 27 94.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of glial fibrillary acidic protein (GFAP) in PBN of ipsilateral and contralateral sides was up-regulated 4 h after occlusal changes in molars, reached peak levels at 24 h, and was then gradually down-regulated.
Negative_regulation (down-regulated) of Gene_expression (expression) of GFAP in molars
1) Confidence 0.59 Published 2007 Journal Cell Tissue Res. Section Abstract Doc Link 17443351 Disease Relevance 0.39 Pain Relevance 0.27
GFAP protein expression was significantly decreased following chronic treatment with clozapine and valproic acid.
Negative_regulation (decreased) of Gene_expression (expression) of GFAP protein
2) Confidence 0.58 Published 2008 Journal Schizophr. Res. Section Abstract Doc Link 18585900 Disease Relevance 0.24 Pain Relevance 0.22
CONCLUSION: Both 650 nm laser and moxibustion pretreatment can inhibit VTP and the mechanism may be related to reducing the activity of AChE and the content of SP, and increasing the activity of LEK and decreasing the expression of c-Fos protein and GFAP.


Negative_regulation (decreasing) of Gene_expression (expression) of GFAP in LEK
3) Confidence 0.57 Published 2010 Journal Zhongguo Zhen Jiu Section Body Doc Link 20886795 Disease Relevance 0 Pain Relevance 0
Shunting at 15d and allowing a three-week post-shunt survival period until 36d, significantly reduced GFAP expression by 48.2% (p < 0.05).


Negative_regulation (reduced) of Gene_expression (expression) of GFAP
4) Confidence 0.56 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1899521 Disease Relevance 0.16 Pain Relevance 0
Since cyclic fluctuations of synaptic numbers in the female have been described only for the endocrine hypothalamus, decrease of immunoreactive GFAP in the IPN during estrus may reflect a down-regulation of GFAP synthesis.
Negative_regulation (down-regulation) of Gene_expression (synthesis) of GFAP in hypothalamus associated with ipn
5) Confidence 0.43 Published 2000 Journal Brain Res. Section Abstract Doc Link 10799667 Disease Relevance 0 Pain Relevance 0.17
Furthermore, mildronate decreased GFAP and iNOS expression but stimulated Notch-3 expression.
Negative_regulation (decreased) of Gene_expression (expression) of GFAP in Notch
6) Confidence 0.43 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000094 Disease Relevance 0.24 Pain Relevance 0.08
In contrast, a robust increase of the distribution and relative levels of GFAP mRNA expression, protein levels and immunoreactivity was observed in the deafferented vestibular and cochlear nuclei beginning at 1 day after inner ear lesion.
Negative_regulation (levels) of Gene_expression (expression) of GFAP mRNA in cochlear
7) Confidence 0.43 Published 2005 Journal Neuroscience Section Abstract Doc Link 15652984 Disease Relevance 0 Pain Relevance 0.36
The expression of glial fibrillary acidic protein (GFAP) in PBN of ipsilateral and contralateral sides was up-regulated 4 h after occlusal changes in molars, reached peak levels at 24 h, and was then gradually down-regulated.
Negative_regulation (down-regulated) of Gene_expression (expression) of glial fibrillary acidic protein in molars
8) Confidence 0.43 Published 2007 Journal Cell Tissue Res. Section Abstract Doc Link 17443351 Disease Relevance 0.39 Pain Relevance 0.27
Using quantitative Western blot analysis, our report showed that intrathecal ketamine down-regulated glial fibrillary acidic protein expression, suggesting inhibition of SNL-induced astrocytic activation, which wasn't influenced by intraperitoneal administration.
Negative_regulation (down-regulated) of Gene_expression (expression) of glial fibrillary acidic protein associated with ketamine, spinal nerve ligature and intrathecal
9) Confidence 0.42 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19383087 Disease Relevance 0.55 Pain Relevance 2.05
In immunohistochemical studies, astrocytes and microglia in rats with spinal hemisection showed significantly increased GFAP and OX-42 expression in both superficial and deep dorsal horns in the lumbar spinal dorsal horn compared to sham controls (* P<0.05) that was prevented in a dose-related manner by PPF.
Negative_regulation (prevented) of Gene_expression (expression) of GFAP in spinal associated with spinal dorsal horn
10) Confidence 0.42 Published 2009 Journal Neuroscience Section Abstract Doc Link 19332108 Disease Relevance 0.69 Pain Relevance 0.93
The effect of shunting in the occipital cortex was more dramatic in reducing the levels of GFAP.
Negative_regulation (reducing) of Gene_expression (levels) of GFAP in occipital cortex
11) Confidence 0.41 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1899521 Disease Relevance 0.14 Pain Relevance 0
Shunting hydrocephalic animals at 15d and allowing them to recover until 21d significantly reduced the amount of GFAP expression by 77% when compared to the untreated hydrocephalic animals (p < 0.01) (Fig. 5).
Negative_regulation (reduced) of Gene_expression (expression) of GFAP
12) Confidence 0.41 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1899521 Disease Relevance 0.15 Pain Relevance 0
Glial fibrillary acidic protein (GFAP) gene expression was decreased in the lesion core, whereas the tissue surrounding this area showed a massive increase in signal intensity.
Negative_regulation (decreased) of Gene_expression (expression) of GFAP
13) Confidence 0.41 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 7523600 Disease Relevance 0.07 Pain Relevance 0.29
Shunting for as little as 6d was effective in reducing the amount of GFAP present in both the parietal and occipital cortices, with the reduction being more dramatic in the occipital cortex.
Negative_regulation (reducing) of Gene_expression (present) of GFAP in occipital cortex
14) Confidence 0.41 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1899521 Disease Relevance 0.49 Pain Relevance 0
The longer three-week shunt duration also provided a dramatic reduction in the level of GFAP present in both the parietal cortex and the occipital cortices.
Negative_regulation (reduction) of Gene_expression (present) of GFAP in parietal cortex
15) Confidence 0.41 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1899521 Disease Relevance 0.25 Pain Relevance 0
Shunting significantly reduced GFAP levels in the 36d shunted group.
Negative_regulation (reduced) of Gene_expression (levels) of GFAP
16) Confidence 0.41 Published 2007 Journal Cerebrospinal Fluid Res Section Abstract Doc Link PMC1899521 Disease Relevance 0.11 Pain Relevance 0
Glial localization of GFAP expression was confirmed by immunohistochemical staining, but in limited areas only.
Negative_regulation (localization) of Gene_expression (expression) of GFAP
17) Confidence 0.39 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2527299 Disease Relevance 0.97 Pain Relevance 0.49
Rat spinal cord astrocytes were cultured in vitro and divided into a control group, cultured with ITS cell culture fluid, and two experiment groups, with Group 1 stimulated with SP at the concentration of 10(-9) - 10(-6) mol/L for 12 hours followed by determination of the expressions of TNF-alpha, IL-1beta, NO and NOS by ELISA and nitrate reductase and colorimetric methods, and Group 2 at 10(-7) mol/L for 0, 24, 48 and 72 hours followed by detection of the GFAP expression by Western blot.
Negative_regulation (detection) of Gene_expression (expression) of GFAP in spinal cord
18) Confidence 0.39 Published 2009 Journal Zhonghua Nan Ke Xue Section Body Doc Link 20218316 Disease Relevance 0 Pain Relevance 0
Furthermore, GFAP expression was obviously down-regulated 24 h after coadministration (ketamine 100 ?
Negative_regulation (down-regulated) of Gene_expression (expression) of GFAP associated with ketamine
19) Confidence 0.37 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.14 Pain Relevance 1.17
The effect of L-AA appeared to be astrocytic specific, because it only reduced the number of GFAP-expressing astrocytes, but not that of NeuN-expressing neurons (Fig. 5B).
Negative_regulation (reduced) of Neg (not) Gene_expression (expressing) of GFAP in neurons
20) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.13 Pain Relevance 0.82

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