INT48664

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Context Info
Confidence 0.57
First Reported 1994
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 5.05
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GFAP) extracellular matrix organization (GFAP) cytoplasm (GFAP)
Anatomy Link Frequency
astrocytes 2
stem cell 2
GFAP (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 65 100.00 Very High Very High Very High
Neuropathic pain 6 93.40 High High
Enkephalin 5 91.28 High High
Demyelination 10 91.08 High High
Antinociceptive 5 91.04 High High
substance P 2 90.08 High High
agonist 62 88.00 High High
cytokine 31 87.20 High High
antinociception 7 86.84 High High
Spinal cord 108 75.00 Quite High
Disease Link Frequency Relevance Heat
Cicatrix 48 100.00 Very High Very High Very High
Cancer 156 99.84 Very High Very High Very High
Injury 284 99.12 Very High Very High Very High
Nociception 10 96.84 Very High Very High Very High
Suicidal Behaviour 7 93.60 High High
Neuropathic Pain 15 93.40 High High
Keloid Scars 23 93.04 High High
Cold Sores 8 92.56 High High
Brain Tumor 67 91.44 High High
Demyelinating Disease 37 91.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Early lesions displayed abundant Gfap-positive cells, although the larger tumors partly lost the expression of Gfap.
Negative_regulation (lost) of Gene_expression (expression) of Gfap associated with cancer
1) Confidence 0.57 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.02 Pain Relevance 0
A biochemical model was established using S100beta, GFAP, and IL-8 to predict injury severity (ASIA A, B, or C).
Negative_regulation (established) of Gene_expression (using) of GFAP associated with injury
2) Confidence 0.41 Published 2010 Journal J. Neurotrauma Section Abstract Doc Link 20038240 Disease Relevance 1.28 Pain Relevance 0.39
Furthermore, Eif2b5 RNAi studies also showed significantly decreased production of GFAP+ astrocytes from human fetal GPs.
Negative_regulation (decreased) of Gene_expression (production) of GFAP in astrocytes
3) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864763 Disease Relevance 0.18 Pain Relevance 0.05
OTA down-regulated GFAP expression while it upregulated vimentin.
Negative_regulation (down) of Gene_expression (expression) of GFAP
4) Confidence 0.21 Published 2008 Journal PPAR Research Section Body Doc Link PMC2367430 Disease Relevance 0.12 Pain Relevance 0.13
OTA down-regulated GFAP expression while it upregulated vimentin.
Negative_regulation (regulated) of Gene_expression (expression) of GFAP
5) Confidence 0.21 Published 2008 Journal PPAR Research Section Body Doc Link PMC2367430 Disease Relevance 0.12 Pain Relevance 0.13
Additionally, biochemical protein analysis supplemented our stereological quantification and demonstrated no changes in protein expression levels of Fibronectin, NG2, Versican, GFAP, and PE-CAM1 at 2 weeks post-transplant.
Negative_regulation (levels) of Gene_expression (expression) of GFAP
6) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690693 Disease Relevance 0.42 Pain Relevance 0
Lesion volume, spared tissue volume, and glial scar area were quantified using GFAP staining and the Cavalieri probe at 4× in all three groups using parasagittal sections, vehicle (n?
Negative_regulation (using) of Gene_expression (staining) of GFAP associated with cicatrix
7) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923623 Disease Relevance 0.55 Pain Relevance 0
42 for GFAP scar, spared tissue, and raphespinal fibers), a small effect of f?
Negative_regulation (tissue) of Gene_expression (scar) of GFAP associated with cicatrix
8) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690693 Disease Relevance 0.10 Pain Relevance 0
The cells continued to show significant expression of the stem cell markers nestin and SOX2, but also of the differentiation markers GFAP and ?
Negative_regulation (show) of Gene_expression (expression) of GFAP in stem cell
9) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707627 Disease Relevance 1.02 Pain Relevance 0
Glial fibrillary acidic protein (GFAP) gene expression was decreased in the lesion core, whereas the tissue surrounding this area showed a massive increase in signal intensity.
Negative_regulation (decreased) of Gene_expression (expression) of acidic protein
10) Confidence 0.01 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 7523600 Disease Relevance 0.07 Pain Relevance 0.29
Ultra-low dose naltrexone attenuated morphine-induced increases in the expression of glial fibrillary acidic protein (GFAP) and CD3/CD11B (OX42)
Negative_regulation (attenuated) of Gene_expression (expression) of acidic protein associated with morphine
11) Confidence 0.00 Published 2010 Journal Mol Pain Section Body Doc Link PMC2862024 Disease Relevance 0.16 Pain Relevance 1.48

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